Review Class Flashcards
Draw a diagram of how a new B cell traffics to the site of an infection.
B cells come from the primary lymphoid organ bone marrow. Makes its way to the lymph node where they mature and then towards the cite of infection via lymphatic and circulatory system. Chemokines attract memory B cells to infection cite.
How do gamma delta T cells go to the infection?
GD cells are in the epithelium during development. They will go from the bone marrow to the thymus and if they survive they go to the epithelium.
What is the function of the cTEC in the thymus?
The cortical thymal epithelium cells. These are antigen presenting cells in the cortex of the thymus which present self and they ensure that double positive cells don’t leave the cortex.
What do mTECs do?
They select against T cells that are reacting too strongly to AIRE (other self) to reduce auto-immunity.
How does antigen traffic through a lymph node?
DCs can pick up Ag and traffic it to the lymph node. Also draining lymphatic can traffic Ag to the lymph nodes. Macrophages can pick up Ag that has leaked into the lymph node and present it.
What are the product of an effective germinal center responses?
Antibodies and memory cells with affinity matured BcRs.
What are the ligands between the T and B cells that cause activation?
3 signals - MHC, costimulatory, and cytokines.
How do B cells become more specific in the germinal centers?
B cells will mutate their functional portion to become more and more specific to the antigen.
Which plasma cells produce the better affinity antibodies ; germ center or plasma cell ?
Germ centered B cell because it is more specific.
Which cell is the best cell in the body to properly activate a naive T cell? Why?
DCs. They have the proper costimulatory signals.
What are the two main types of interactions for the B and T cells?
T cell dependent B cell responses - in germinal centers
T cell independent
How do you activate a Th17 cell?
TcR-MHC, costimulation, cytokine secretion =
IL6, IL23 and TGFbeta milieu.
Th17 releases IL-17A, IL-17F, and IL-22
What are Th2’s main jobs?
Allergies and parasites
What kinds of cytokines will CD8+ T cells produce?
IFNgamma, TNFalpha, CCL5, granzyme B, perforin
What is TcR usage bias?
Is when there is restricted variable region usage as well as a restricted and conserved motif of CDR3 that is used in the immune response to a specific antigen.
