REVIEW Flashcards
<p>3 components of a virus</p>
<p>nucleic acid, protein capsid, some have a lipi envelope</p>
<p>Viruses depend on host cells for what?</p>
<p>replication</p>
<p>What is a viral genome made of</p>
<p>RNA or DNA, never both</p>
<p>What part of the virus do antibodies target</p>
<p>viral receptors</p>
<p>What types of viruses can reassort?</p>
<p>ones with segmented nucleic acids</p>
<p>what are more stable, enveloped or non-enveloped?</p>
<p>non-enveloped</p>
<p>What is the type of RNA that can be made into proteins by ribosomes?</p>
<p>+ stranded mRNA</p>
<p>What does a -stranded RNA have to do</p>
<p>get copied into a + stranded RNA or get copied into DNA to be turned into a +mRNA</p>
<p>What do all RNA viruses encode </p>
<p>RNA-dependent RNA polymerase (except for retroviruses which make an RNA dependent DNA polymerase)</p>
<p>What other types of viruses need to bring a polymerase?</p>
<p>negative strand RNA viruses bring a polymerase to copy the RNA</p>
<p>How does one serologically detect viral infection</p>
<p>IgM: acute
| IgG: 4x greater in convalescent sera than in acute sera</p>
<p>How does on detect virus directly</p>
<p>detection in cell culture with eukaryotic cells</p>
<p>How does one detect virion particles</p>
<p>proteins (usually immunological assays... like flu rapid tests) OR PCR</p>
<p>What are the 7 acute viruses</p>
<p>1. influenza
2. RSV
3. rotavirus
4. norovirus
5. polio
6. arboviruses
7. hep A and E</p>
<p>What are the 2 virologically latent viruses</p>
<p>1. herpes
| 2. HIV</p>
<p>What are the 2 chronic viruses</p>
<p>1. hep B
| 2. Hep C</p>
<p>What 2 viruses have segmented nucleic acid genomes that can reassort</p>
<p>flu A and rotavirus</p>
<p>What part of the resp tract does rhinovirus infect</p>
<p>nasal cavity mostly because it replicates at temps below body temp</p>
<p>what does rhinovirus cause</p>
<p>common cold</p>
<p>What part of the resp tract does parainfluenza infect</p>
<p>mostly larynx and a bit of pharyns</p>
<p>what does parainfluenza cause</p>
<p>laryngitis and croup</p>
<p>What part of the resp tract does RSV infect</p>
<p>bronchioles</p>
<p>what does RSV cause</p>
<p>bronchiolitis</p>
<p>What part of the resp tract does influenza infect</p>
<p>alveoli and sometimes the upper respiratory tract</p>
<p>What can influenza cause</p>
<p>pneumonia</p>
<p>who does RSV selectively infect?</p>
<p>children < 2</p>
<p>Describe the pathophysiology of RSV infection</p>
<p>LRTI infection -> bronchiolar inflammation -> bronchiolar narrowing -> wheezing, decreased O2 exchange, gas trapping ->recovery</p>
<p>Is there immunity to RSV</p>
<p>NO. You can be re-infected many times. BUT, the repeated infections will get less severe with each re-infection</p>
<p>How is influenza spread</p>
<p>person to person you can spread A, B, and C. Birds will only infect pigs and humans - humans and pigs cannot infect birds. pigs and humans can infect each other both ways</p>
<p>Who are the hosts for Flu A</p>
<p>mammals and birds (lots of pig-related stuff)</p>
<p>Who are the hosts for Flu B</p>
<p>Humans (and seals sometimes)</p>
<p>Who are the hosts for Flu C </p>
<p>only humans</p>
<p>what is the most severe of all flu</p>
<p>Flu A</p>
<p>what has antigenic drift?</p>
<p>Flu a and B</p>
<p>What has antigenic shift</p>
<p>only Flu A</p>
<p>what is in the flu vaccine</p>
<p>2 flu A and 1 B</p>
