REVIEW

Question 1

<p>3 components of a virus</p>

Answer 1

<p>nucleic acid, protein capsid, some have a lipi envelope</p>

Question 2

<p>Viruses depend on host cells for what?</p>

Answer 2

<p>replication</p>

Question 3

<p>What is a viral genome made of</p>

Answer 3

<p>RNA or DNA, never both</p>

Question 4

<p>What part of the virus do antibodies target</p>

Answer 4

<p>viral receptors</p>

Question 5

<p>What types of viruses can reassort?</p>

Answer 5

<p>ones with segmented nucleic acids</p>

Question 6

<p>what are more stable, enveloped or non-enveloped?</p>

Answer 6

<p>non-enveloped</p>

Question 7

<p>What is the type of RNA that can be made into proteins by ribosomes?</p>

Answer 7

<p>+ stranded mRNA</p>

Question 8

<p>What does a -stranded RNA have to do</p>

Answer 8

<p>get copied into a + stranded RNA or get copied into DNA to be turned into a +mRNA</p>

Question 9

<p>What do all RNA viruses encode </p>

Answer 9

<p>RNA-dependent RNA polymerase (except for retroviruses which make an RNA dependent DNA polymerase)</p>

Question 10

<p>What other types of viruses need to bring a polymerase?</p>

Answer 10

<p>negative strand RNA viruses bring a polymerase to copy the RNA</p>

Question 11

<p>How does one serologically detect viral infection</p>

Answer 11

<p>IgM: acute

| IgG: 4x greater in convalescent sera than in acute sera</p>

Question 12

<p>How does on detect virus directly</p>

Answer 12

<p>detection in cell culture with eukaryotic cells</p>

Question 13

<p>How does one detect virion particles</p>

Answer 13

<p>proteins (usually immunological assays... like flu rapid tests) OR PCR</p>

Question 14

<p>What are the 7 acute viruses</p>

Answer 14

<p>1. influenza

2. RSV
3. rotavirus
4. norovirus
5. polio
6. arboviruses
7. hep A and E</p>

Question 15

<p>What are the 2 virologically latent viruses</p>

Answer 15

<p>1. herpes

| 2. HIV</p>

Question 16

<p>What are the 2 chronic viruses</p>

Answer 16

<p>1. hep B

| 2. Hep C</p>

Question 17

<p>What 2 viruses have segmented nucleic acid genomes that can reassort</p>

Answer 17

<p>flu A and rotavirus</p>

Question 18

<p>What part of the resp tract does rhinovirus infect</p>

Answer 18

<p>nasal cavity mostly because it replicates at temps below body temp</p>

Question 19

<p>what does rhinovirus cause</p>

Answer 19

<p>common cold</p>

Question 20

<p>What part of the resp tract does parainfluenza infect</p>

Answer 20

<p>mostly larynx and a bit of pharyns</p>

Question 21

<p>what does parainfluenza cause</p>

Answer 21

<p>laryngitis and croup</p>

Question 22

<p>What part of the resp tract does RSV infect</p>

Answer 22

<p>bronchioles</p>

Question 23

<p>what does RSV cause</p>

Answer 23

<p>bronchiolitis</p>

Question 24

<p>What part of the resp tract does influenza infect</p>

Answer 24

<p>alveoli and sometimes the upper respiratory tract</p>

Question 25

<p>What can influenza cause</p>

Answer 25

<p>pneumonia</p>

Question 26

<p>who does RSV selectively infect?</p>

Answer 26

<p>children < 2</p>

Question 27

<p>Describe the pathophysiology of RSV infection</p>

Answer 27

<p>LRTI infection -> bronchiolar inflammation -> bronchiolar narrowing -> wheezing, decreased O2 exchange, gas trapping ->recovery</p>

Question 28

<p>Is there immunity to RSV</p>

Answer 28

<p>NO. You can be re-infected many times. BUT, the repeated infections will get less severe with each re-infection</p>

Question 29

<p>How is influenza spread</p>

Answer 29

<p>person to person you can spread A, B, and C. Birds will only infect pigs and humans - humans and pigs cannot infect birds. pigs and humans can infect each other both ways</p>

Question 30

<p>Who are the hosts for Flu A</p>

Answer 30

<p>mammals and birds (lots of pig-related stuff)</p>

Question 31

<p>Who are the hosts for Flu B</p>

Answer 31

<p>Humans (and seals sometimes)</p>

Question 32

<p>Who are the hosts for Flu C </p>

Answer 32

<p>only humans</p>

Question 33

<p>what is the most severe of all flu</p>

Answer 33

<p>Flu A</p>

Question 34

<p>what has antigenic drift?</p>

Answer 34

<p>Flu a and B</p>

Question 35

<p>What has antigenic shift</p>

Answer 35

<p>only Flu A</p>

Question 36

<p>what is in the flu vaccine</p>

Answer 36

<p>2 flu A and 1 B</p>