Review 6: Cholesterol and Cholesterol Esters Flashcards
1
Q
What is Mevalonate?
A
- an important intermediate in cholesterol biosynthesis
- formed in reaction catalyzed by HMG-CoA reductase (rate limiting enzyme)
2
Q
What effect do statins have on the cholesterol biosynthesis pathway?
A
INHIBIT IT by inhibiting HMG CoA reductase
3
Q
HMG reductase is involved in ____________ while HMG synthase is involved in _____________
A
cholesterol; ketone bodies
4
Q
What is the rate limiting enzyme in bile acid synthesis?
A
7-alpha-hydroxylase
5
Q
What is the rate limiting enzyme in cholesterol ester synthesis (cholesterol storage)?
A
ACAT (acyl-CoA acyltransferase)
6
Q
Cholesterol excess has which 3 effects?
A
1) inhibits HMG- CoA reductase
2) activates ACAT
3) activates 7-alpha-hydroxylase
7
Q
What are the 3 rate limiting enzymes in lipid metabolism?
A
1) ACAT
2) HSTL
3) CPT-1
