Review #2 Flashcards
What subunit of the TCR is responsible for signal transduction?
Zeta
What acessory molecules are responsibe for stabilizing the TCR?
CD3
And CD4 or CD8
Where are gamma:delta TCR types located?
Mucosal tissue
How many peptide chains make up an antibody?
4: 2 heavy and 2 light chains
What type of reactions are responsible for antibody binding?
Weak interactions
No covalent bonding
What are the functions of antibodies?
Neutralization of foreign cells and toxings
Complement activation
Opsonization
ADCC
What is the function of the recognition end?
Provides specificity for antigen binding
What is the function of the effector (commonality) end?
Provides link for the effector or immunologic function
I.e. binds Fc receptors on phagocytes or NK cells, and binds complement
What chromosome contains MHC genes?
Chromosome 6
*MHC is the locus on the chromosome, not the gene product
What cells have MHC class II?
APCs:
Dendritic
Macrophages
B cells
What cells have MHC class I?
Every cell in the body, except RBCs
Which MHC class presents the larger peptide?
MHC class II
What occurs when DCs receive the danger signal?
Starts expressing costimulatory molecules
CD80/86 - T cell response
CD40 - b cell response
Where does antigen uptake, processing and presentation occur?
Pericortex
White pulp
What are the three signals required for T cell activation?
TCR-MHC binding
Costimulation with CD80/86
IL-2 for proliferation
