Dose-Response Relationships Flashcards
1
Q
Which direction do competitive antagonists shift the D-R curve?
A
Right shift
2
Q
Which direction does potentiation shift the D-R curve?
A
Left shift
3
Q
Which direction does a noncompetitive antagonist shift the curve?
A
Down shift
*Reduces efficacy
4
Q
What is the therapeutic ration or index?
A
The lethal dose (50)/effective dose (50) ratio for a drug
The larger the ratio, the safer the drug
5
Q
What is the certain safety factor?
A
Tells you if the two curves overlap
LD1/ED99 ratio for a drug
If <1, the two curves overlap
