Reversible Cell Injury L38 Flashcards
Define Cloudy Swelling
Reversible cell damage characterized by accumulation of water inside the cells
Describe the Pathogenesis of cloudy swelling
The mitochondria become swollen and breakdown. Damaged mitochondria decrease ATP production causing failure of Na/k pump with retention of Na and water inside the cell.
Pathological features of cloudy swelling usually affect the parenchymatous organs?
Liver, renal convoluted tubules and heart muscle
Affected organ in Cloudy Swelling
showed grossly as?
•Size
•Color
• Consistency
• Weight
• Borders
Enlarged and swollen
Pale (due to compression of the capillaries by the swollen cells)
Soft
Heavy
Rounded
Affected organ in Cloudy Swelling
showes what in Microscopic pic?
• Cytoplasm
• Nucleus
• Capillaries between cells
Red Fine granular
Normal
Compressed
Hydropic Swelling characterized morphologically by
Swelling of the cells
Vacuoles in the cytoplasm (due to excess water accumulation)
Both Hydropic Swelling and cloudy swelling are characterized by Swelling of the cells but the diff is?
The lesion is more advanced than cloudy swelling
Pathogenesis of Hydropic Swelling iss?
Similar to cloudy swelling
Gross picture of Hydropic Swelling
Similar to cloudy swelling
•Size: Enlarged and swollen • Color: Pale (due to compression of the capillaries by the swollen cells) • Consistency: Soft • Weight: Heavy
• Borders: Rounded
Microscopic picture of Hydropic Swelling
Cells
Cytoplasm
Nucleus
Capillaries between cells
Swollen
Multiple vacuoles
Normal
Compressed
Def of Fatty Change
Pathologic accumulation of fat (triglycerides) in parenchymal cells.
Site of fatty change ?
1- liver
2- Heart, muscle, and kidney
liver is the most common site why?
because it is the major organ involved in fat metabolism
Pathogenesis of Fatty Change
Injured cells can not metabolized Fat due to diminished enzyme activity, so it accumulate in
cytoplasm
Causes of fatty change
1- Alcoholic 2- Obesity 3-Protein malnutrition,
4- Diabètes mellites, 5- Toxins
