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Kumar Valori > Reumatologie - LES > Flashcards

Reumatologie - LES Flashcards

1
Q

LES - raportul sexelor

A

F : M = 9 : 1

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2
Q

LES - varsta maxima de debut

A

20-40 ani

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3
Q

LES - in ce grupuri etnice este prevalenta mai mare si cat este?

A

femei africane / caraibene - 1 : 250

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4
Q

LES - prevalenta

A

1 : 1.000 - 1 : 10.000

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5
Q

LES - rata de concordata intre gemenii monozigoti

A

pana la 25%

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6
Q

LES - rata de concordanta intre gemenii dizigoti

A

3%

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7
Q

LES - cate gene se asociaza cu dezvoltarea LES si cate studii de analiza genomica au dus la identificarea acestora

A

aprox. 20 gene - 3 studii

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8
Q

LES - deficienta homozigota a genelor caror compentente ale complementului se asociaza cu risc mai mare de a dezvolta LES

A

C1q
C2
C4

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9
Q

LES - ce medicamente pot induce forme usoare de lupus, fara afectare renala sau de SNC

A

hidralazina
izoniazida
procainamida
penicilamina

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10
Q

LES - nivelurile serice ale caror citokine sunt in mod particular legate de activitatea crescuta a inflamatiei in LES?

A

Il-10
IFNalfa

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11
Q

LES - frecventa afectarii articulare

A

> 90%

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12
Q

LES - frecventa mialgie

A

aprox. 50%

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13
Q

LES - frecventa miozita

A

< 5%

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14
Q

LES - frecventa afectarii tegumentului

A

85%

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15
Q

LES - frecventa fotosensibilitate

A

40-50%

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16
Q

LES - frecventa afectarii toracice (pulmonare)

A

50%

17
Q

LES - frecventa afectarii cordului

A

25%

18
Q

LES - frecventa afectarii renale clinice

A

30%

19
Q

LES - frecventa afectarii SNC

A

pana la 60%

20
Q

LES - frecventa sindromului Sjogren secundar

A

15%

21
Q

LES - frecventa Ac antifosfolipidici

A

25-40%

22
Q

LES - ce procent de pacienti dezvolta modificari retiniene in tratamentul pe termen lung cu hidroxiclorochina?

A

7,5%

23
Q

LES - la ce doze este riscul mai mare de a dezvolta modificari retiniene in tratamentul cu hidroxiclorochina?

A

> 5 mg/kgc/zi

24
Q

LES - in ultimii cati ani a scazut considerabil mortalitatea in LES

A

50 ani

25
Q

LES - care este rata de supravietuire la 10 ani in absenta complicatiilor de organ

A

90%

26
Q

LES - care este riscul de a naste un copil cu sindrom lupic neonatal in cazul incare Ac anti-Ro si anti-La sunt pozitivi la mama?

A

2%

27
Q

LES - frecventa febra

A

50%

28
Q

LES - frecventa fatigabilitate

A

75%

29
Q

LES - frecventa scadere ponderala

A

50%

30
Q

LES - frecventa fenomen Raynaud

A

20%

31
Q

LES - care este probabilitatea ca o ruda de grad primar sa dezvolte la randul sau boala?

A

3%

32
Q

LES - care este probabilitatea ca o ruda de grad primar sa dezvolte autoanticorpi?

A

20%

33
Q

LES - cu cat timp inaintea aparitiei altor manifestari clinice poate aparea fenomenul Raynaud?

A

ani

Kumar Valori (5 decks)

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