Retinoids Flashcards
1
Q
Tretinoin (4: compound, indication, route-MOA, adverse rxn) + limitations
A
- Transretinoic acid
- mild-moderate acne; sundamage
- Topical. binds all RARs; increases cell turnover and decreases cohesiveness b/w follicular epithelial cells
- red/crusted + hyper/hypo pigmentation
+ No pregnancy or lactation use
2
Q
Adapalene (4: compound, indication, route-MOA, adverse rxn) + limitations
A
- retinoid
- acne
- Topical. Selective for RARbeta; affects differentiation and keratinization and inflammatory processes
- red scaly itchy skin
+ No pregnancy or lactation use
3
Q
Isotretinoin (4: compound, indication, route-MOA, adverse rxn) + limitations
A
- 13-cis-RA
- severe recalcitrant acne
- Oral. Binds all RARs. Inhibit sebum and causes comedolysis
- photosensitivity, dry skin, corneal tox, hyperostosis and ligament calcification long term
+ TERATOGEN (NEED BC)
4
Q
Acitretin (4: compound, indication, route-MOA, adverse rxn) + limitations
A
- Retinoid
- pustular psoriasis
- dries skin
- photosensitivity + liver, msk, mucocutaneous vit a rxn; rarely: ICH and capillary leak syndrome
+ NO PREGNANCY FOR 3 YEARS POST TREATMENT
