MSK Path

Question 1

Spinal Muscular Atrophy is due to …. of …. horn via lack of …. gene

Answer 1

degeneration…anterior….SMN1

Question 2

Duchenne Muscular Dystrophy is …. linked defect in ……

Explain Gower sign

What is main tx for DMD?

Answer 2

x linked….dystrophin

Kids can’t get up from floor 2/2 proximal muscle weakness

Corticosteroids

Misc: Heart, brain, and proximal muscle weakness. Calf-pseudohypertrophy

Question 3

perimysial and perivascular infiltrates with PERIFASICULAR ATROPHY is often seen in ….

Answer 3

dermatomyositis

Question 4

endomysial infiltrates + scattered atrophy often seen in

Answer 4

polymyositis

Question 5

endomysial infiltrates + scattered atrophy + rimmed bodies/inclusions

Answer 5

inclusion body myositis

Question 6

not responsive to steroids (name myopathy)

Answer 6

inclusion body myositis

Question 7

ragged red fibers are pathomnemonic for

Answer 7

mitochondrial myopathy

Question 8

extra ocular eye movements are often found in

Answer 8

mitochondrial myopathy

Question 9

antibodies to calcium channels on presynaptic membrane

Answer 9

LEMS

Question 10

high association with malignancy in this inflammatory myopathy

Answer 10

dermatomyositis

Question 11

high protein and low wbc in csf

Answer 11

CIDP