Retina and Optic Nerve Flashcards

1
Q

Normal Variation

  • Dogs
  • Cats
A
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2
Q

Retinal Dysplasia

  • who
  • other causes?
A

• Usually inherited
– Can be associated with multiple ocular anomalies
• Other causes:
– Maternal viral infections
• Canine herpes and parvo viruses, feline panleukopenia
– Vitamin A deficiency
– X-ray irradiation
– Drug toxicities
– Intrauterine trauma

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3
Q

findings with retinal dystrophy

A
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4
Q

Retinal Dysplasia in Labrador Retrievers
Hereditary oculoskeletal dysplasia

A
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5
Q

Collie Eye Anomaly (CEA)

A
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6
Q

Inherited Retinopathies

A
  • May initially affect rods, cones, or RPE
  • Very long list of affected breeds
  • Majority are autosomal recessive
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7
Q

retina and optic nerve (meekins)

Progressive Retinal Atrophy
• Clinical signs:

A

Bilateral – progressive loss of vision–blindness
Decreased night vision (nyctalopia) usually first sign
– Progressive decrease in PLR
– Larger than normal resting pupil size
• Owner will sometimes report increase in “eye shine”
– Cataract formation in very late stages

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8
Q

retina and optic nerve (meekins)

Sudden Acquired Retinal Degeneration Syndrome (SARDS)

  • what
A

• SARDS-_acute_ photoreceptor death
• Usually middle aged to older dogs; female overrepresented
• All breeds affected
• Associated clinical signs
– May have ‘Cushing’s-like’ signs for weeks or months prior to vision loss

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9
Q

retina and optic nerve (meekins)

Sudden Acquired Retinal Degeneration Syndrome
• Clinical signs:

A

Acute vision loss
– Variable PLR
• Chromatic PLR
• Red light –
• Blue light +
– Fundic exam
• NORMAL initially
• Chronic cases
– Retinal degeneration

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10
Q

retina and optic nerve (meekins)

Sudden Acquired Retinal Degeneration Syndrome

  • Diagnosis:
  • Treatment:
A
  • Diagnosis:
    • Electroretinogram (ERG)
    • May have elevated ALP, or other Cushing’s-like changes on blood work; less commonly diagnosed with Cushing’s via traditional screening tests
  • No proven treatment-permanent blindness
    • Emphasize quality of life as blind pet
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11
Q

retina and optic nerve (meekins)

Retinal Detachments

small vs large

A
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12
Q

retina and optic nerve (meekins)

Rhegmatogenous retinal detachment

A
  • Retinal tear present which allows liquefied vitreous to enter subretinal
    space
  • Primary ocular disorder (previous cataract surgery, inherited vitreal
    degeneration, etc.)
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13
Q

retina and optic nerve (meekins)

Non-rhegmatogenous retinal detachment

A
  • Remains attached at ora ciliaris retinae & optic disc
  • Serous sub-retinal fluid-bullous retinal detachment
  • Exudative retinal detachments-inflammatory or exudative sub-retinal fluid
  • Systemic disease
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14
Q

retina and optic nerve (meekins)

Differentials for Non-rhegmatogeous RD

A

• Depends on type of sub-retinal fluid/material
• Exudate (cloudy or discolored, yellow)
– Same as chorioretinitis (i.e., posterior uveitis) → suspect systemic infection
• Transudate (clear)
– A.k.a. bullous
– *Hypertension
– Hypoproteinemia
– Idiopathic (steroid responsive?)
• Dog specific

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15
Q

retina and optic nerve (meekins)

Retinal Detachments

  • always do ______ with non-rhegmatogenous patients
A
  • Always perform a systemic work-up in animals with non-rhegmatogenous retinal detachments
    – CBC/chemistry panel/urinalysis
    – Blood pressure
    – Chest radiographs
    – Titers/antigen tests if any suspicion of infectious cause
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16
Q

retina and optic nerve (meekins)

Surgical Repair of Retinal Detachments

A

• Only appropriate for rhegmatogenous detachments
• Laser retinopexy
– 2 rows of burns around detachment to create adhesions
– Prophylactic vs. barrier
• Retinal reattachment

17
Q

Retinal Hemorrhages: location

A
18
Q

Retinal Hemorrhage
• Etiology
• Work-up

A
  • Etiology
    – Anemia
    – Coagulopathy
    – Systemic hypertension
    – Hyperviscosity
    – Systemic infections that cause vasculitis
  • Work-up
    – Thorough physical exam!
    – CBC (platelets!), chemistry panel, UA
    – Blood pressure
    – Clotting times
    – BMBT
    – Chest radiographs
    – Titers/antigen testing if any suspicion of infectious cause
19
Q

retina and optic nerve (meekins)

Optic Nerve Inflammation

A
  • = Optic neuritis
  • Unilateral or bilateral
  • Can involve any segment of optic nerve (intraocular vs. retrobulbar)
  • Associated with sudden blindness, fixed and dilated pupils
20
Q

retina and optic nerve (meekins)

Optic Neuritis

A
21
Q

retina and optic nerve (meekins)

DDX Optic Neuritis

A
22
Q

retina and optic nerve (meekins)

Optic Neuritis Diagnostics

A

• CBC, chemistry panel, urinalysis
• Titers/antigen tests for infectious organisms
• Chest radiographs
• MRI or CT scan
• CSF tap
*Think of optic neuritis as a neurologic disease!*

23
Q

retina and optic nerve (meekins)

Optic Neuritis Treatment

A
  • Referral?
  • Treat primary cause
  • Systemic steroids (immunosuppressive dose)
  • Oral antibiotics (empiric)
  • Prognosis for vision = poor
24
Q

retina and optic nerve (meekins)

Summary

  • 3 hallmark signs of retinal degeneration:
  • SARDS results in…
  • Rhegmatogenous retinal detachments are due to…
  • Non-rhegmatogenous retinal detachments are due to…
  • Optic neuritis is…
A
  • 3 hallmark signs of retinal degeneration:
  • *– Tapetal hyperreflectivity**
  • *– Retinal vessel attenuation**
  • *– Optic disc pallor**
  • SARDS results in sudden blindness with a normal ophthalmic exam (ERG needed to definitively diagnose)
  • Rhegmatogenous retinal detachments are due to primary ocular disease
  • Non-rhegmatogenous retinal detachments are due to systemic disease
  • Optic neuritis is a neurologic disease!