Respiratory Viruses 1 Flashcards
Can macrophages engulf and kill viruses?
Yes- they CAN engulf and kill viruses
Which types of viruses are more easily destroyed- enveloped or non-enveloped?
Enveloped! They are generally easily destroyed by soap
Which serotypes most commonly cause disease in humans?
Most A
Sometimes B
Which two viruses can undergo reassortment?
Influenza and rotavirus
What accounts for the difference in severity of rotavirus in children vs adults?
Enterotoxic NSP4- age dependent ability to cause diarrhea
What is the most common cause of bronchiolitis?
Respiratory Syncytial Virus (RSV)
What are two of the most common causes of the common cold?
Rhinovirus
Coronavirus
What are two of the most common causes of croup?
Parainfluezna virus
Coronavirus
What are three common causes of viral pneumonia?
Influenza Virus
RSV
Adenovirus
What is the incidence of viremia in influenza?
Very low- the infection normally stays restricted to the lungs and airway
How do antibodies neutralize influenza virus?
The best antibodies block influenza HA activity. This prevents viral entry/ membrane fusion
What causes epidemic flu?
Antigenic drift - point mutations, particularly in HA spikes
Describe the genetics of the flu virus
Segmented RNA genome with 8 different segments
What causes pandemic flu?
Segmented RNA reassortment creates antigenic shifts responsible for flu pandemics
How do amantidine and rimantadine work?
They block M2 proteins
