Enteric Viral Infections Flashcards

1
Q

What is the mechanism of transmission of EV-D68?

A

Respiratory

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2
Q

What is Pleconaril useful for?

A

Immunocompromised people with severe disseminated disease with EV-D68

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3
Q

Which vaccine is effective post-exposure?

A

Hepatitis A

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4
Q

What type of vaccine is the hepatitis A vaccine?

A

Killed vaccine- IM injection

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5
Q

How is at a higher risk for severe respiratory illness caused by EV-D68?

A

Children with asthma- severe symptoms include wheezing and difficulty breathing

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6
Q

What time of the year are people more likely to get infected with enteroviruses?

A

Summer and fall

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7
Q

What is the MOA of Pleconaril?

A

Drug incorporates into viral particles and changes the shape of the particle such that it can no longer bind a receptor to infect a new host cell

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8
Q

Pleconaril is the first antiviral drug to have activity against which class of viruses?

A

Picornaviruses (predominant cause of the common cold)

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9
Q

What part of the body is affected by rotavirus?

A

Infection with rotavirus is primarily restricted to the villus epithelium of the small intestine

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10
Q

What age group has a symptomatic infection with rotavirus?

A

Outcome of infection is age-related: symptomatic infection occurs in young Children 6 months to 2 years of age

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11
Q

What is the pathogenesis of diarrhea with rotavirus?

A

Ca2+ released by NSP4 –> diarrhea

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12
Q

Describe the rotavirus vaccine.

A

Pentameric live-attenuated vaccine that gives a 98% protection against severe disease

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13
Q

Antibodies against which two rotavirus viral proteins are neutralizing?

A

VP4, VP7

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14
Q

What type of viruses undergo reassortment?

A

Segmented viruses- rotavirus and influenza virus

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15
Q

What is the transmission of rotavirus?

A

Fecal-oral

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16
Q

Describe the vaccines for norovirus

A

There are no vaccines available

17
Q

Can you get norovirus more than once?

A

Yes- multiple genotypes exist so you can get it multiple times

18
Q

How do we detect norovirus?

A

RT-PCR of stool sample