Respiratory - Respiratory failure Flashcards
What is respiratory failure? What are the different types?
Respiratory failure may be acute, chronic or acute on chronic (e.g. a patient with an exacerbation of COPD and pre-existing hypoxia). Abnormal levels of arterial oxygen (<8kPa) or carbon dioxide (>6kPa) are used to define the presence of respiratory failure, which is divided into 2 types:
1) Type I (hypoxic) failure: failure of oxygenation
2) Type 2 (hypercapnic) failure: failure of ventilation to remove CO2
Generally, hypercapnic failure is the result of a disorder with respiratory muscles (“pump failure”), whereas hypoxaemic failure is usually due to pulmonary pathology. However, type II failure often supersedes type I failure as the patient becomes exhausted.
What is the A-a gradient?
Alveolar O2 and CO2 are interdependent and high alveolar partial pressures of carbon dioxide results in a lower partial pressure of oxygen. The alveolar - arterial gradient, is calculated from the alveolar gas equation and is a measure of ventilation and perfusion mismatch (reflecting the severity of lung disease).
A-a gradient = FiO2 - PaO2 - 1.25(PCO2)
What is a normal A-a gradient?
2-4kPa is the normal range. It increases with age and FiO2 >0.28 (FiO2 = fraction of oxygen in inspired air).
What diseases increase the A-a gradient?
Hypoxaemia is low arterial partial pressure of oxygen (this is slightly different to hypoxia, which is a low TISSUE partial pressure of oxygen).
It is caused by decreased PAO2, diffusion defect, V/Q mismatch, and right to left shunts.
The A-a gradient can be used to compare the causes of hypoxaemia. As already mentioned, it is normally between 2 - 4 kPa, since O2 normally equilibrates between alveolar gas and arterial blood PAO2 is approximately equal to PaO2.
The A-a gradient is increased (i.e. >4kPa) if O2 does not equilibrate between alveolar gas and arterial blood and PAO2 is GREATER than PaO2.
What are the causes of hypoxaemia (and therefore type 1 respiratory failure)?
Hypoxaemia can be caused by:
1) Shunt (e.g. Eisenmenger’s): the lung is perfused but not ventilated (the opposite of dead space). A right to left shunt leads to hypoxaemia
2) Ventilation/ perfusion mismatch (e.g. PE, pulmonary oedema, COPD/ obstruction, pneumonia): THIS IS THE MOST COMMON CAUSE OF HYPOXAEMIA. Even in diseases like pulmonary fibrosis where one might expect diffusion block. Poorly ventilated alveoli contribute to hypoxaemia which cannot be compensated for alone by increasing ventilation.
3) Diffusion block (e.g. Fibrosis): a thickened interstitium between alveolus and capillary (uncommon). Only important during exercise when erythrocytes have insufficient time to equilibrate for gas exchange.
4) Low FiO2 (e.g. altitude)
5) Hypoventilation (e.g. drug overdose - opiates): ventilation is inversely proportional to PaCO2. The interdependence of PaO2 and PaCO2 thus leads to hypoxaemia in hypoventilation
Of the causes of hypoxaemia and therefore type I failure, which are associated with an increased A-a gradient?
The A-a gradient increases only when oxygen cannot equilibrate across the alveolar capillary membrane, therefore in hypoxaemia caused by hypoventilation and low FiO2 the A-a gradient is normal. All other causes of hypoxaemia are associated with increased A-a gradients.
Which cause of hypoxaemia cannot be corrected for by increasing FIO2 (i.e. with supplementary oxygen)?
A right to left shunt leads to hypoxaemia that does NOT respond to 100% oxygen.
What are the signs of type I respiratory failure?
- central cyanosis
- decreased PaO2; normal PaCO2
- agitated
- confused
- coma
- tachypnoeic
- dyspnoeic
- tachycardic
What is hypoxia?
Is decreased oxygen delivery to tissues. It is caused by decreased blood flow, hypoxaemia, decreased Hb concentrations, CO poisoning and cyanide poisoning.
What determines oxygen delivery to tissues?
This is described by the following equation:
O2 delivery = Cardiac output x O2 content
O2 content of blood depends on Hb concentration, O2 binding capacity of Hb and PO2 (which determines % saturation of Hb by O2).
Anything that affects cardiac output and O2 content can lead to hypoxia (not just hypoxaemia).
Name some causes of hypoxia?
1) Decreased cardiac output - causes hypoxia by decreased blood flow
2) Hypoxaemia - decreased PaO2 causes decr. % saturation of Hb
3) Anaemia - decreased [Hb] causes decr. oxygen content of blood
4) CO poisoning - decr. O2 content
5) Cyanide poisoning - decr. O2 utilization by tissues
How does the body respond to tissue hypoxia?
Hypoxia induces EPO synthesis. This is a growth factor that is synthesized in the kidneys in response to hypoxia. Decreased oxygen delivery to the kidney causes increased production of hypoxia-inducible factor 1 alpha. This directs the synthesis of mRNA for EPO which ultimately promotes development of mature RBCs.
What causes hypercapnia?
This is a PaCO2 of <6kPA. Hypercapnia is associated with type 2 respiratory failure alongside low PaO2. It is caused by pump failure or ventilatory failure, causes include:
1) defective central control of breathing - e.g. drug overdose, most causes of coma
2) neuromuscular disease - ALS, spinal cord lesions, MG, GBS, polio
3) chest wall disease - kyphoscoliosis, large effusions
4) primary lung disease - COPD
What is key in the management of respiratory failure?
It is important to establish whether the onset of respiratory failure is acute, chronic or acute on chronic. The key to managing respiratory failure is treating the underlying disease process. There are various strategies for treating hypoxia and hypercapnia that occur in respiratory failure.
What variable performance oxygen devices can be used in the treatment of hypoxaemia associated with respiratory failure?
Oxygen can be delivered by variable or fixed performance devices:
Variable performance devices: air is entrained during breathing whilst oxygen is delivered from a reservoir. The latter may be the nasopharynx, mask or reservoir bag. The FiO2 delivered to the lungs therefore depends on the oxygen flow rate, the patients inspiratory flow, respiratory rate, and the amount of air entrained.
- e.g. nasal cannulae: flow rates up to 4L/min, nasopharynx is the reservoir
- e.g. face mask: flow rates exceed 5L/min to stop rebreathing of CO2
- e.g. non re breath masks: these have a reservoir bag. A one way valve stops exhaled air entering the oxygen reservoir. High flow rates 10-15L/min provide FiO2 >60%