Dermatology - Skin and systemic diseases Flashcards
What is erythema nodosum and what conditions are associated with it?
These are painful blue/red lesions on the anterior shins. They are associated with the "3's": - sarcoid - strep infections - sulfonamides
They may also occur in TB, OCP, IBD and Behcets
What is erythema multiforme?
This is a symmetrical target lesion on the palms, soles and limbs.
Possibly mediated by IgM deposition.
Usually secondary to infection: HSV (70%), mycoplasma
What drugs are associated with erythema multiforme?
"SNAPP" Sulfonamides Nevirapine, NSAIDS Allopurinol Penicillin carmabazePine
What causes Stevens-Johnson syndrome and TEN?
These are severe variants of EM.
Nearly always drug induced.
PC: fever, mucosal and skin ulceration and necrosis.
What is pyoderma gengrenosum?
Wide deep ulceration with violaceous border Purulent surface Undermined edge Commonly occurs on the legs Heals with cribriform (pitted) scars
Associated with IBD, AIH, Wegener’s, RA, Leukaemia
Treatment is with high dose systemic steroids
What is Livedo reticularis?
These are persistent, mottled blue/red lesions that don't blanch Commonly found on the legs Triggered by cold Causes: - idiopathic - vasculitis: RA, SLE, PAN - obstruction: anti-phos, cryoglobulinaemia - Sneddon's syndrome: LR + CVAs
What rash is associated with rheumatic fever?
Erythema marginatum (circular shaped erythematous rash that resembles the mitral annulus)
What is the skin manifestation of Lyme disease?
Erythema chronicum migrans
What are the skin manifestations of Crohn’s disease?
Perianal ulcers and fistulae
EN
Pyoderma gangrenosum
What rash is associated with dermatomyositis? What other features can be present?
Heliotrope rash on eyelids Shawl sign (macular rash) Gottron's papules Mechanic hands Nailfold erythema, telangiectasia
What are the skin manifestations of diabetes mellitus?
Ulcers Candida Kyrle disease Acanthosis nigricans Necrobiosis lipoidica (shins) Granuloma annulare (hands, feet)
What rash is associated with coeliac disease?
Dermatitis herpetiformis (elbows)
Graves disease is associated with this characteristic rash…
Pre-tibial myxoedema
What are the skin manifestations of rheumatoid arthritis?
Rheumatoid nodules
Vasculitis (palpable purpura)
What are the features of CREST syndrome?
Calcinosis Reynauds phenomenon oEsophageal dysmotility Sclerodactyly Telangiectasia
