Respiratory Pharmacology Flashcards
ALBUTEROL Brand Names
Proventil
Ventolin
ALBUTEROL Class (2)
Sympathomimetic
Bronchodilator
ALBUTEROL MOA
Beta 2 agonist causing smooth muscle relaxation
ALBUTEROL Indication
Bronchospasm in pt’s with COPD/asthma
ALBUTEROL Contraindications (3)
Allergy
Tachycardia
Dysrhythmias especially via digitalis
ALBUTEROL Adult Dose
2.5mg
dilute 0.5mL of 0.5% soln for inhalation with 2.5mL NS
administer via 10-15 minutes
ALBUTEROL Special Considerations (4)
Pregnancy C
Antagonized by beta blockers
Synergistic with other sympathomimetics
May precipitate chest px and dysrhythmias
DEXAMETHASONE Brand Name
Decadron
DEXAMETHASONE Class
Corticosteroid
DEXAMETHASONE MOA
Suppresses acute and chronic inflammation
DEXAMETHASONE Indications (6)
Anaphylaxis Asthma Spinal cord injury Croup Increased ICP Adjunct to shock treatment
DEXAMETHASONE Contraindications (1)
Allergy
DEXAMETHASONE Adult Dose
10-100mg IV (1mg/kg slow IV bolus)
4-8mg per protocol max of 20mg
DEXAMETHASONE Drug interactions
Calcium
Metaraminol
DEXAMETHASONE Considerations (3)
Unknown pregnancy safety
Protect med from heat
Toxic long term
DIPHENHYDRAMINE Brand Name
Benadryl
DIPHENHYDRAMINE Class
Antihistamine
DIPHENHYDRAMINE MOA (3)
Blocks cellular histamine receptors
Decreases vasodilation
Reverses extrapyramidal reactions
DIPHENHYDRAMINE Indications (2)
Symptomatic relief of allergies, allergic rxn, anaphylaxis, acute dystonic rxn
Blood administration rxn
DIPHENHYDRAMINE Contraindications (5)
Asthma Glaucoma Pregnancy HTN Infants
DIPHENHYDRAMINE Adult Dose
25-50mg IM/IV/PO
DIPHENHYDRAMINE Considerations (2)
Don’t use in pregnancy or with infants
If used for anaphylaxis, used with epi and steroids
HYDROCORTISONE/METHYLPREDNISOLONE Brand Names (2)
Solu-Cortef
Solu-Medrol
HYDROCORTISONE/METHYLPREDNISOLONE Class
Corticosteroid
HYDROCORTISONE/METHYLPREDNISOLONE MOA (3)
Suppresses acute/chronic inflammation
Replaces absent glucocorticoids
Immunosuppressive effects
HYDROCORTISONE/METHYLPREDNISOLONE Indications (4)
Asthma
Anaphylaxis
Croup
Adrenal Insufficiency
HYDROCORTISONE/METHYLPREDNISOLONE Contraindication
Allergy
HYDROCORTISONE Dose
2mg/kg IV dose
HYDROCORTISON Max Dose
100mg
METHYLPREDNISOLONE Dose
2mg/kg IV dose
METHYLPREDNISOLONE Max Dose
125mg
HYDROCORTISONE/METHYLPREDNISOLONE Considerations (2)
Protect from heat
Toxic with long term use
IPATROPIUM Brand Name
Atrovent
IPATROPIUM Class
Bronchodilator
IPATROPIUM MOA
Block the action of acetylcholine at the parasympathetic sites in bronchial smooth muscle –> bronchodilation
IPATROPIUM Indication
Bronchospasm with COPD/emphysema
IPATROPIUM Contraindication
Allergy to atropine or derivatives
IPATROPIUM Adult dose
0.5mg via NEB, usually mixed with 2.5mg of Albuterol for DuoNeb
IPATROPIUM Special Consideration
Pregnancy B
RACEMIC EPI Class
Sympathomimetic
RACEMIC EPI MOA
Stimulates Beta 2 receptors
Bronchodilation via smooth muscle relaxation
Decreases airway resistance
Inhibits histamine release
RACEMIC EPI Indications (3)
Croup
Laryngeal edema
Bronchial asthma
RACEMIC EPI Contraindications (3)
HTN
Underlying cardiovascular disease
Epiglottitis
RACEMIC EPI Dose
11.25mg (0.5mL) diluted in 2.5mL of NS in Neb
RACEMIC EPI Considerations (3)
Pregnancy C
Excessive use may cause bronchospasm
May have strong rebound when drug wears off