Respiratory- Paeds Flashcards

1
Q

What are the commonest Respiratory infections?

A

Preschool- 6-8 reso infx per year
Life threatening- bronchiolotis, pneumonia

Pathogens:
Viruses-80-90%
Resp syncytial virus- (RSV), rhinovirus, parainfluenza, influenza, metaoneumovirus, adenovirus.

RSV- spectrum of illnesess; bronchiolitis, croup, pneumonia or a common cold.
Bacterial:
Strep pneumoniae (pneumococcus), Haemophilus influenzae,
Moraxella catarrhalis, Bordetella pertusis- whooping cough,
Mycoplasma pneumoniae.
TB globally.
Dual inx- 2 viruses or V+B

Epidemics- RSV every winter.

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2
Q

What are some host and environmental fx affecting resp infx?

A

⬆️ risk
Parental smoking esp maternal
Poor socioeconomic status + large family, overcrouded, damp housing
Poor nutrition
Male
Immunodeficiency- 1o or 2o HIV infc, chemo
Haemodynamically significant Congenital heart disease
Underlying lung disease:
Bronchopulmonary dysplesia (02 requirments) in preterms, CF, asthma.

Greatest admission and mortality risk: infants
Increased risk when starts nursery or school.

Resp infx- common, rarely indicate undrelying disease.

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3
Q

Howmdo we classify resp infx?

A
According to level of infx
URTI
Laryngeal/ tracheal infx
Bronchitis
Pneumonia
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3
Q

URTI - what are the SS?

A
80% involve throat, nose or ears.
URTI-->
Commom cold (coryza)
Sore throat (pharyngitis incl tonsilitis) 
Acute otitis media 
Sinusitis (uncommon) 

PC
Nasal discharge + blockage,
Fever
Painful throat + earache. Cough depends.

URTIs may cause:
Nose closed- obstructed breathing–> so diff feeding
Febrile convolusions
Acute exacerbations of asthma.

Infants- admit to exclude severe if feeding inadequate or parental reassuarance.

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4
Q

What happens in common colds?

A

Coryza- commonest childhood infection
CF–> clear or mucopurulent nasal discharge and nasal blockage.
Commonest- viruses–> rhinoviruses (100 diff serotypes) , coronaviruses, + RSV.
Fever + pain- paracetamol + ibuprofen.
Educate- no cure

Antibiotics- not indicated as no benefit + secondary bacterialninfx is uncommon.

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5
Q

Sore throat- pharingitis- what happens?

A

Phranyx and palate are inflamed - local lymph nodes are enlarged + tender.
Mostly viral- adenoviruses, enteroviruses, rhinoviruses commonest.

Older children–> group A b- haemolytic streptococcus

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6
Q

Tonsilitis- what happens?

A

Form of pharingitis- intense inflamation of tonsils + purulent exudate (aspruthkia)
Common pathogens:
Group A b-haemolytic streptococci( usually aldready lives there) + Epsein- Barr virus (EBV) -> infectious mononucleosis.

Cannot distinguish clinically if V or B cause of tonsilitis.
Bacterial infx- common assc sx->
Secere pharingitis + tonsilitis antibiotics- penicillin or erythromycin if pen allergic
Even tho inly 1/3 is B.

Streptococcal- havest all- to avoid rheumatic fever- 10 D tx required (not in UK cz reumatic fever rare)

If unable to swollow fluids or foods- admit IV fluids and analgesia.

Amoxicillin avoided- might caise maculopapular rash if tonsilitis due to infectious mononucleoisis.m

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7
Q

Whats infectious mononucleosis?

A

MO
Glandular fever
Kissing disease
Transmission by Saliva
Widespread viral disease mostly by EBV (herpes family)
PC- fever, malaise, fever, sore throat.
Amoxicillin contraindicated- spreads them..?

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8
Q

What hapoens in the acute infx of middle ear?

A

Acute otitis media (OM)
Nost kids have at least one
Coomonest at 6-12M
20% will have 2-3 episodes
Infants + young children- prone cz Eustachian tubes short, horizontal and function poorly.
CF-
Pain in ear and fever ! Every kid with fever must have their tympanic membranes examined.
Bright and red + bulging w/ loss of normal light reflection.
Occasionally- acute perforation of eardrum with pus visible in external canal.

Pathogens- viruses - esp RSV + rhinovirus
B- pneumococcus, H influenza (non- typeable) + Moraxslla catarrhalis.

Serious complications:
Mastoditis, meningitis (uncommon)
Pain- analgesia- paracetamol, ibuprofen - regular better than intermittent
Most cases resolve spontaneously

Antibiotics shorten pain duration but not proven to reduce hear loss.
Give prescription but ask parents to take it only if kid unwell after 2-3 days.
Amoxicillin used. Antihistamimes not beneficial..

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9
Q

Whats the glue ear?

A

Recurrent ear infx- ottitis media with effusin - glue ear.
Asymptomatic apart from hearloss.
Eardrum- dull and retracted , often fluid visible.
Confirm- flat trace on tympanometry + evidence of conduction loss on pure tone audiometry (possible if >4Y)
Or reduced hearing on distraction hearing test.
Common2-7 Y peak 2.5-5Y
No effect on hear loss : antibiotics and steroids.

Can develop speech delays –> learning diff at schl.
Insert ventilation tube ( grommets)
Adenoidectomy more long benefit.
Why- adenoids harvest organisms within biofilms that contribute to infx being carried to eustachian tubes.
+ grossly enlarged adenoids may obstruct the tubes fx leading to poor ventilatiom of middle ear,
Kids with recurrent URTis and chronic glue ear do not resolve conservativley.
If problems occur after grommet insertion , reinsertion with adenoidecromu advocated

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10
Q

Whats Sinusitis?

A

Infx ofnparanasal sinuses- from viral URTIs
2o bact infx- pain, swelling, tenderness over cheeck from maxillary sinus infx

Frontal sinuses develop in late childhoood- frontal sinusotis uncommon before 10Y

Acute sinusitis- antibiotics, analgesia + topical decongestants.

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11
Q

When do you condsider tonsillectomy and adenoidectomy?

A

Shrink in late chilhood.
Commonest operation in kods- recurrents tonsilitis
Balance with risks of surgery:
1. Recurrent severe tonsilitis (not URtIs, tonsilectomy reduces number of episodes of tonsilitis by 1/3.
2. Peritonsilar abscess
3. Obstructive sleep apnoea- adenoids usually removed as well.

Adenoids increase in size till 8Y
Young- grow faster than airway 2-8Y narrowing of airway.
If nasal space efficiently narrowed.. Adenoidectomy

Indications for both being removed:
Recurrent otitis media w/ effusions w/ hearing loss.
Obstructive sleep apnoea (absolute indication)

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12
Q

Whatbare some DD of acute Upper airways obstruction?

A

Common: viral laryngotracheobromhotis - croup, very common.

Rare causes
Epiglottitis
Bacterial tracheatis
Inhalation of smoke and hot air fumes
Trauma to throat
Allergic lanyngeal angioedema - seen in anaphylaxis and recurrent croup
Hypocalcaemia due to poor VitD intake
Infectious mononucleosis- severe lymph node swelling
Measels
Diptheria
Laryngeal foreign body 
Retropharyngeal abscess
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13
Q

What hapoens in laryngeal and tracheal infiections?

A

Young children- mucasal inflammation and swelling- produced by tracheal and laryngeal infections can rapidly cause life- threatening obstruction of the airway.
Severe conditions can cause upper airway obstruction:
A.Stridor- rasping sound heard predominantly on Inspiration.
B. Hoarsness due to inflammation of vocal cords
C. Barking cough like sea lion
D. Variable degree of dyspnoea.

Severity - clinically by chest retraction( paei mesa) - subcostal, intercostal, sternal recession - better indicator than RR.
None, only on crying, at rest.
Degree of stridor- none, only crying, at rest, biophasic.

Severe obstruction–> ⬆️RR, HR, agitation.
⬆️ hypoxia + need for urgent intervention-> central cyanosis or drowsiness.

Most reliable hypoxaemia measure- oxygen saturation by pulse oximetry.

Total obstruction of upper airaway may be precipitated by examining the throat using spatula.
Avoid unless full resuscitation equipment and personnel are at hand.

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14
Q

How do you manage acute upper airway obstruction?

A

DO not examine throat ❗️ ❌
Reduce anxiety by being calm, confident, well prganised.
Onserve carefully for signs of hypoxia or deterioration.
If severe-
Administer nebulised epinephrine (adrenaline) + contact anaesthetist.

If Resp F develops (⬇️O2) from increasing airway obstruction, exhaustion or secretions blocking airways- urgent tracheal intubation is required.

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15
Q

What are the effects of epinephrine in anaphylaxis?

Upper airway obstruction

A

Administered nebulised: (inhaled)
⬆️ BP
Reduces mortality and morbidity in croup–> laryngotracheobronchitis
But
Not used in epiglottitis- can be deleterious.

16
Q

Whats croup?

A

Laryngotracheobronchitis- inflammation of mucosa, increased secretions affecting airways
Odema- dangerous- subglottic area- trachea narrowing in young children.
Viral croup-95% , parainfluenza commonest, RSV, influenza.
6M-6Y, peak 2Y.
Autumn.
Sx worse at night, barking cough, coryza –> fever, harsh stridor, hoarsness.

Mild UAO- resection + stridor disappear at rest- managed at home
Oral dexamethasone, oral orednisolone + nebulised steroids (budesonide) reduce severity and duration and need for hospitalisation.
Severe:UAO
Nebulised epinephrine w/ oxygen by facemask transient impeovement.
Reccurent- atopy?

17
Q

What happens in pseudomembranous croup? Bacterial tracheitis

A

Rare
Dangerous
Similar to severe viral croup - higher fever, appears toxic, thick airway obstruction + rapidly progressivle UAO
By S. Aureus

Tx- IV antibioticcs and intubation and ventilation if required.

18
Q

Acute epiglotitis- disease framework

A

Life threatening emergency ⬆️ risk of resp obstructiom
H. Imfluenzae type b. Immunization&raquo_space;99% reduction
Intense swelling of epiglottis + surrounding tissue assc w/ septicaemia
1-6Y but all age groups.

Onset:
Higher fever in all, toxic looking child, intensly painfull throat prevents speaking or swolling!! Saliva drouls down chin.
Soft inspiratory stridor + rapidly increasing respiratory difficulty over hours
Child sitting immobile, upright, with open mouth to optimise airway.

Suspected- urgent hospital admission
Child intubated under general anaesthetic.

19
Q

How do you distinuish croup -V from epiglottitis?

A

Croup. Epiglottitis
Onset- over days. Over hours
Preciding
Coryza Yes. No
Cough. Severe, barking. Abscent or slight
Able to
Drink. Yes. No
Drooling
saliva. No. Yes
Appearance. Unwell. Toxic, very ill
Fever. 38.5
Stridor. Harsh, rasping. Soft, whispering
Voice, cry. Hoarse. Muffled, reluctant ro speak.

20
Q

Whats pertussis?

A

Caused by Bordetella pertusis
Paroxysmal cough followed by inspiratory whoop and V
in infants- apnoea rather than whoop - potentially dangerous

Dx- culture of organism on perinasal swab,
Marked lymphocytosis on blood film !

Highly contagious resp infx
Endemic
After a week of coryza- child develops whooping cough , worse spasms of cough at night ,
During paroxysm - child goes red or blue in face and mucus flows from nose to mouth.
Susceptible- 15x10.9/L on FBC
Close contacts- erythromycin prophylaxis
Unvaccinated kid contacts should be vaccinated.
Vaccine- reduces risk of developing disease and reduces severity in those who have it. Does not guarantee full protection.

21
Q

LRTIs- diseases?

Whatbare thebDDx of wheezing?

A

Obstruction of airways below thoracic outlet- usually more expiratory sounds
Classical sx- wheezing

DDx of wheezing
Common- asthma, (recurrent wheezing episodes, identifyiable triggers, typically over >6Y)
Broncholitis- 1st wheezing episode usually under

22
Q

Disease framework of pneumonia

A

Etiology- infl of pulmonary tissue, assc w/ consolidation of alveolar spaces

PC-
Incidence⬆️ in 1st year, Viral infx commonest

23
Q

Whats broncholitis? CF and inv?

A

LRTI that has wheezing and signs of resp distress

Epidimiology- Commonest LRTI in infants, affects about 50% of children in first 2Y of life , peak incidence 6M, winter + early spring.
⬆️ incidence of asthma in later life

Etiology:
RSV (>50%), parainfluenza, influenza, rhinovirus, adenovirus, M.pneimoniae (rare)

CF
Prodrome of URTI w/ cough and fever
Fedding difficulties, irritability
Whezzing, crackles, resp distress, tachypnoea, tachycardia, retractions, poor air entry
Sx peak at 3-4d

Invx
CXR- only in severe disease, poor response, to therapy, chronic episodes: air trapping, peribronchial thickening, atelectasis, increased linear markings
NP swab- direct detection of viral antigen (immunoflurescence)
WBC can be normal

24
Q

How do you treat bronchiolitis?

A

Self limiting D, sx lasting 2-3 w,
Mild to moderate distress: supportive: PO, or IV hydration, antipyretics for fever, refular or humidified high flow O2
Severe Distress:
As above +- intubation and ventilation as needed,
Consider Rebetol ( Ribavirin) in high risk groups : bronchopulmonary dysplesia, CHD, congenital lung disease, immunodeficient.
Monthly RSV-Ig or palivizumab (Monoclonal Ab against the F- glycoprotein of RSV is protective against severe disease.

Anribiotics no effect unless 2o bacterial imfection

25
Q

What are the indications for hospitalisation in broncholitis?

A

Hypoxia 60/min and retractions after several salbutamol masks
Past H of chronic lung disease, haemodynamically sign congenital heart disease, neuromuscular problem, immunocompromised
Young infants

26
Q

Disease framework of asthma

A

Characterised by recurrent episodes of airway hyperreactivity, bronchospasm, and inflammation, reversible small airway obstruction.
Very common, PC in early childhood,
Assc w/ other atopic diseases such as allergic rhinitis or atopic dermatitis - eczema, hay fever, asthma.

PC
Episodic bouts of wheezing, dyspnoea, tachypnoea, cough( night + early morning w/ activity or on cold)
O/E hyperresonant chest, prolonged expiration, wheeze.

Triggers: URTI (viral, Mycoplasma), weather (cold, humidity,) allergens(pets) irritants (cigarette smoke), exercise, emotional stress, drugs (ASA, b- blockers)

27
Q

How do we classify asthma?

A

Mild: occasional 3 per week, decreased exercise tolerance, sometimes needs systemic corticosteroids.

Severe: daily and nocturnal sx, frequent ED visits + hospitalisations, usually needs systemic steroids.

28
Q

How do you manage acute asthma?

A
  1. O2- keep o2 sats >90% + fluids if dehydrated
  2. B-2 agonists- salbutamol (Ventolin )MDI + spacer 10 puffs (4-8) every 20mins for 3 doses
  3. Ipatropium bromide- (Atrovent) if severe : MDI + spacer 4-8 puffs every 20 mins up to 3 hrs, nebulised as needed
  4. Steroids- prednisolone 1-2mg per kg 5d or dexamethasone (0.3mg/kg/d x5d or 0.6 for 2 days.) Severe disease-IV steroids.
  5. Continue to observe–> discharge pt if asymptomatic 2-4hrs after last dose
29
Q

How do you manage chronic asthma?

A

Stepwise 0-11 ages, >12Y follow adult guidlines.
Step 1- intermittent asthma (step 2-6 for persistent asthma requiring daily meds , step up or down based on pts control

Kids

30
Q

What are the complications of asthma and prognosis?

A

Decreased linear growth rate due to poorly controlled asthma more usual than from overprescription of inhaled steroids, chest wall deformity, recurrent infx, status asthmaticus can be fatal.
1/3 of deaths occur under the age of 5.

Prognosis
Often remits during puberty - sx free adults, esp those who had mild asthma.

31
Q

What are the indications for asthma hospitalisation?

A

Duration of sx, severity of sx, severity of obsteuction, response to ED tx, course and severity of previous exacerbations, med used at exacerbation, access to medical care/ meds, presence of psychic illness

Individualised decision to admit to ward: FEV1 or PEF 42mmHg,
O/E severe sx, drowsiness, confusion

32
Q

What happens in Cystic Fibrosis (CF)

A

Autosomal recessive condition characterised by recurrent lung infx, malabsorption and F to thrive.

Aetiology
1/ 3000 live births, mostly Caucasian
AR, CFTR gene on chromosome 7 - DF 508 mutation in 70%
Dysfunctional chloride channel on apical membrane of cells
Leads to relative dehydration of airway decretions, –> impaired mucociliary transport and airway obstruction.

CF
Neonatal- meconium ileus, prolonged jaundice, antenatal bowel perforation
Infancy: pancreatic insufficiency with steatorrhoea and FTT , anaemia, hypopeoteinaemia, hyponatraemia.
Childhood: heat intolerance, wheezing, chronic cough, recurrent chest infx (S. Aureus, Pneumoniae aeruginosa, H. Influenzae)
Hemoptysis, nasal polyps, distal intestine obstruction syndrome, rectal prolapse, clubbing of fingers.
Older pts- COPD, infertility (males), decreased fertility (females)

Inv
Gold standard- Sweat chloride test x 2 >50- 60 mEq/L, Na >60mmol/L, weight of sweat > 100mg on 2 occasions.
LungFTs- obstructive picture with air trapping and hyperinflation (⬇️FEV-1, ⬆️TLC (hyperinflated)?
Guthrie’s test- ⬆️ serum immunoreactive trypsin (all newborn screened in UK)
ANC- 1st trimester CVS (95% sensitivity) , 2trimester- ⬇️ intestinal ALP in amniotic fluod (90% sensitivity)

False +ves–> malnutrition, atopic dermatitis, hypothyroidism, hypoparathyroidism, GSD, adrenal imsufficiency, G6PD, Kleinefelter syndrome, technical issues, autoimmune dysfunction, familial cholistasis syndrome.

False -ves–> techn problem with test, malnutrition, skin edema, mineralocorticoids.

33
Q

How do you manage CF?

A

Nutritional counseling- high calorie diet, pancreatic enzyme replacements, fat solume vitamin supplements.
Mx of chest disease:
Physiotherapy, postrural drainage, exerice, bronchodilators, aerosoled DNAase and inhaled hypertonic saline, antibiotics, (cephalosporin, cloxacillin, ciprofloxacin, inhaled tobramycin depending on sputum (C+S) , lung transplatation,
Genetic counseling

MDT
Respiratory: 1. Flucloxacillin prophylaxis for S. Aureus
2. 80% of CF pts are chronically infected w/ pseudomonas.ntxbwith nebulised antibiotics (colomycin +/- gentamicin/tobramycin) + intermittent course of IV antibiotics to decrease size of colony (every 3M)
3. Allergic bronchopulmonury aspergilosis: steroids +- itraconazole
4. ⬆️ airway hyperresponsivness presents withn asthma like sx : bronchodilators +- ICS if responsive
5. Nebulised recombinant DNAase acts as mucolytic.

34
Q

What other mx except resp would a CF pt need?

A

Nutritional
If gastrostomy- facilitate high calorie intake - enteric coated pancreatic enzyme (Creon) . Ursodeoxycholic acid to prevent gallstones.

Immunisations- usual scedule + pneumoccocus, + influenza annual.
Physio >2x d even when well, swimming ideal !!!
Gene therapy -> viral vectors/liposomes to deliver normal copies of CF gene to make CFTR protein. Still at research stage.

35
Q

What are some complications and prognosis of CF?

A

Respiratory: bronchiectasis, cor pulmonale, (late) Resp F, pneumothorax ( poor prognostic sign) , hemoptysis,

GI: Cirrhosis, Portal HTN, distal intestinal obstruction syndrome, gallstones,

Endocrine: DM, ⬇️ fertility. 99% of males are infertile due to obstructiom and abnormal development of vas deference. Females subfertile but succesful pregnancies happen.

Psych- behaviour problems- due to compromised lifestyle and morbidity.

Prognosis- most sufferers survive adult life(mean- 40Y) . Kids with pseudomonas colonization have 2-3 fold increased mortality over 8Y.