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Pharmacology Exam 1 > Respiratory Drugs > Flashcards

Respiratory Drugs Flashcards

1
Q

Beta2 Agonists, name 4

A

Short Acting: Albuterol Inhalation, Levalbuterol
Long Acting: Formoterol, Salmeterol

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2
Q

SABA MOA

A

Stimulates beta2-adrenergic receptors, causing bronchodilation

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3
Q

SABA SE

A

Tremor, palpitations, headache, increased heart rate

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4
Q

SABA BBW

A

None

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5
Q

SABA ADRs

A

Paradoxical bronchospasm, cardiovascular effects

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6
Q

LABA MOA

A

Long-acting beta2 agonist, maintains bronchodilation

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7
Q

LABA SE

A

Headache, muscle cramps, tremor, dry mouth

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8
Q

LABA BBW

A

Increased risk of asthma-related death

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9
Q

LABA ADRs

A

Prolonged QT interval, palpitations, tachycardia, hypokalemia

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10
Q

Xanthine Derivative, name 1

A

Theophylline

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11
Q

Theophylline MOA

A

Inhibits phosphodiesterase, increasing cAMP and causing bronchodilation

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12
Q

Theophylline SE

A

Insomnia, gastrointestinal disturbance

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13
Q

Theophylline BBW

A

None

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14
Q

Theophylline ADRs

A

Seizures, arrhythmias

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15
Q

Anticholinergics, Name 2

A

Ipratropium bromide
Tiotropium

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16
Q

Anticholinergics MOA

A

Antagonizes acetylcholine at muscarinic receptors in airways

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17
Q

Anticholinergics SE

A

Dry mouth, cough, headache, sinusitis, sore throat

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18
Q

Anticholinergics BBW

A

None

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19
Q

Anticholinergics ADRs

A

Worsening of glaucoma, urinary retention, dry mouth, constipation

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20
Q

Leukotriene Modifiers, name 1

A

Montelukast

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21
Q

Montelukast MOA

A

Blocks leukotriene receptors, reducing inflammation and bronchoconstriction

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22
Q

Montelukast SE

A

Abdominal pain, headache

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23
Q

Montelukast BBW

A

Neuropsychiatric events (agitation, depression, suicidal thoughts)

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24
Q

Montelukast ADRs

A

Hepatic eosinophilic infiltration

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25
Q

Oral Inhalation Corticosteroids, name 4

A

Beclomethasone dipropionate HFA
Budesonide
Fluticasone propionate HFA
Mometasone furoate

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26
Q

Oral Corticosteroids MOA

A

Reduces inflammation by suppressing migration of leukocytes and reversing capillary permeability
Inhibit the synthesis and release of inflammatory cytokines and mediators, such as prostaglandins and leukotrienes, that contribute to inflammation in the airways.

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27
Q

Oral Corticosteroids SE

A

Oral candidiasis, hoarseness, cough

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28
Q

Oral Corticosteroids BBW

A

None

29
Q

Oral Corticosteroid ADRs

A

Possible adrenal suppression, bone loss

30
Q

Intranasal Corticosteroids, name 2

A

Budesonide
Fluticasone

31
Q

Intranasal Corticosteroids MOA

A

Reduces inflammation, treats symptoms of allergic rhinitis

32
Q

Intranasal Corticosteroids SE

A

Nasal irritation, epistaxis, pharyngitis

33
Q

Intranasal Corticosteroids BBW

A

None

34
Q

Intranasal Corticosteroids ADRs

A

Possible adrenal suppression, nosebleeds

35
Q

Inhaled Anti-Inflammatory Agents, name 2?

A

Cromolyn nebulizer solution (asthma)
Cromolyn Intranasal (allergic rhinitis)

36
Q

Cromolyn MOA

A

Stabilizes mast cells, prevents release of histamine

37
Q

Cromolyn SE

A

Cough, throat irritation, wheezing, nasal irritation, sneezing

38
Q

Cromolyn BBW

A

None

39
Q

Cromolyn ADRs

A

Rarely, pulmonary infiltrates associated with eosinophilia.
Epistaxis

40
Q

Inhaled Antihistamines, name 1

A

Azelastine

41
Q

Antihistamine MOA

A

H1-receptor antagonist, reduces allergic inflammation

42
Q

Azelastine SE

A

Bitter taste, headache, nasal irritation

43
Q

Azelastine BBW

A

None

44
Q

Azelastine ADRs

A

Rare: Anaphylaxis, palpitations

45
Q

Oral Antihistamines (1st Gen), Name 2

A

Diphenhydramine
Hydroxyzine

46
Q

1st Gen Oral Antihistamines MOA

A

Antagonizes H1 receptors; has anticholinergic and sedative effects

47
Q

1st Gen Oral Antihistamine SE

A

Drowsiness, dry mouth, dizziness

48
Q

1st Gen Oral Antihistamine BBW

A

None

49
Q

1st Gen Oral Antihistamine ADRs

A

QT prolongation, CNS depression, heart palpitations

50
Q

2nd Gen Oral Antihistamines, Name 3

A

Cetirizine
Fexofenadine
Loratadine

51
Q

2nd Gen Oral Antihistamines MOA

A

Selective H1-receptor antagonist; non-sedating

52
Q

2nd Gen Oral Antihistamines SE

A

Headache, nausea, dizziness

53
Q

2nd Gen Oral Antihistamine BBW

A

None

54
Q

2nd Gen Oral Antihistamine ADRs

A

Rare: Severe allergic reactions, heart palpitations

55
Q

Antitussives, name 2

A

Dextromethorphan
Benzonatate

56
Q

Dextromethorphan MOA

A

Suppresses cough reflex by acting on the cough center in the medulla

57
Q

Dextromethorphan SE

A

Dizziness, nausea, drowsiness

58
Q

Dextromethorphan BBW

A

None

59
Q

Dextromethorphan ADRs

A

Abuse potential, serotonin syndrome

60
Q

Benzonatate MOA

A

Suppresses cough by numbing the stretch receptors in the lungs and airways

61
Q

Benzonatate SE

A

Sedation, headache, stomach upset

62
Q

Benzonatate BBW

A

None

63
Q

Benzonatate ADRs

A

Severe: Choking, respiratory depression

64
Q

Expectorants, Name 1

A

Guaifenesin

65
Q

Guaifenesin MOA

A

Increases the volume and reduces the viscosity of tracheobronchial secretions

66
Q

Guaifenesin SE

A

Nausea, vomiting, dizziness

67
Q

Guaifenesin BBW

A

None

68
Q

Guaifenesin ADRs

A

Rare: Allergic reactions, rash

Pharmacology Exam 1 (4 decks)

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