Respiratory Distress Syndrome Razi

Question 1

Respiratory distress syndrome (RDS)?

Answer 1

Surfactant deficiency; primarily in premature infants; its incidence is inversely related to gestational age and birthweight

Question 2

The major constituents of surfactant are?

Answer 2

-Dipalmitoyl phosphatidylcholine (lecithin),
• Phosphatidylglycerol
• Apoproteins (surfactant proteins SP-A, SP-B, SP-C, and SP- D)
• Cholesterol

Question 3

What are the lab criteria for
Respiratory failure in newborn?

Answer 3

-PaCO2 > 60 mmHg (hypoxemia)
● pH < 7,20 (metabolic acido)
● PaO2 < 50 mmHg (hypercapnia)

Question 4

What are the clinical characteristics in a newborn with respiratory distress syndrome?

Answer 4

Intercostal and subcostal retractions
Tachypnea (>60) (rapid breathing)
Cyanosis
Apnea (cessation of breathing)
Dyspnea (shortness of breath)
Nasal flaring

CADITN

Question 5

Respiratory distress syndrome may occur also in which babies?

Answer 5

• Infant with diabetic mother
• Perinatal asphyxia(O2 deprivation)
• Surfactant protein-C deficiency (familial predisposition)
• Meconium aspiration syndrome
• Pneumoniae

Question 6

Bronchopulmonary Dysplasia relation with gestational age?

Answer 6

BPD increases inversely with gestational age.