Respiratory Flashcards

1
Q

respiration def

A

cellular metabolism and use of oxygen

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2
Q

ventilation def

A

breathing; movement of air in conducting tubes and alveoli

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3
Q

external respiration def

A

movement of air between alveoli and pulmonary capillaries

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4
Q

internal respiration def

A

movement of air between systemic capillaries and tissues of body

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5
Q

perfusion def

A

blood flow

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6
Q

alveolar cell types (2)

A
  1. structure

2. surfactant

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7
Q

3 functions of respiratory system

A

ventilation, diffusion, perfusion

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8
Q

lobes per lung

A

right = 3, left = 2

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9
Q

pressure of pulmonary arteries

A

25/10

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10
Q

chemoreceptors stimulate breathing in response to ___

A

increase in PaCO2 (and therefore pH)

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11
Q

peripheral stimulate breathing in response to ___

A

decrease in PaO2

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12
Q

mucous blanket in airways contain immune mediators such as (3)

A

immunoglobulin (IgA), PMNs (leukocytes), interferon

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13
Q

phagocytic cell in alveoli

A

macrophage

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14
Q

type of study and purpose of lung scan

A

morphologic; detection of emboli, infarction, pneumonia, and emphysema

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15
Q

type of study and purpose of bronchoscopy

A

morphologic; detect cancer, remove foreign bodies

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16
Q

type of study and purpose of sputum study

A

morphologic; detect microbes, observe presence of pus, observe presence of blood, assess color and odor (indicative of infection)

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17
Q

purpose of physiologic lung studies

A

show the affect of disease on lung function

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18
Q

cause of cyanosis

A

increase in reduced Hb (not bound to O2), i.e. low O2 sats

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19
Q

hypoxemia def

A

inadequate O2 in blood; leads to hypoxia

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20
Q

hypoxia def

A

inadequate O2 in body tissues, local or generalized; caused by hypoxemia or ischemia

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21
Q

ischemia def

A

inadequate perfusion (blood flow) to deliver oxygen; leads to hypoxia

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22
Q

hypoventilation leads to:

A

hypercapnia, hypoxemia, respiratory acidosis

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23
Q

hyperventilation leads to:

A

hypocapnia, respiratory alkalosis, probably hypoxemia

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24
Q

obstructive ventilatory disorders makes ___ very difficult

A

expiration

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25
Q

restrictive ventilatory disorders makes ___ very difficult

A

inspiration

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26
Q

chronic bronchitis def

A

increased mucus production for long time (3+ months or 2+ years in a row); d/t hypertrophy and hyperplasia of goblet cells and inflammation

27
Q

emphysema def

A

decrease in number of functional alveoli and ducts

28
Q

asthma def

A

hypersensitivity reaction; obstructive disorder; bronchial narrowing, bronchospasm, edema, and hypersecretion of mucus; mediated by IgE

29
Q

bronchiectasis def

A

chronic dilation of medium sized bronchi/bronchioles d/t inflammation

30
Q

pathogenesis of cystic fibrosis

A

chloride channels across multiple epithelia of the body are blocked with protein (lungs, pancreas, intestines, and apocrine sweat glands); causes increased mucus production and viscosity

31
Q

extrapulmonary disorders that cause restrictive lung disease

A

decreased compliance/elasticity of lungs or thoracic wall; neuro changes that depress respiratory function; musculoskeletal abnormalities like kyphosis or scoliosis;

32
Q

pleural and parenchymal disorders causing restrictive lung disease

A

pleural effusion; pneumothorax; atelectasis; pneumonia; pulmonary fibrosis

33
Q

relationship/difference between pleural effusion and atelectasis

A

pleural effusion can cause atelectasis

34
Q

risks for developing PE

A

being bedridden –> venous stasis; vein injury; hypercoagulability

35
Q

PE obstructs blood flow where?

A

out of right ventricle into pulmonary circulation

36
Q

2 types of acute respiratory failure

A
  1. hypoxemic, normocapnic: PaCO2 is normal or low at rest (hyperventilation)
  2. hypercapnic: PaCO2 is high (ventilatory failure/ hypoventilation)
37
Q

2 main characteristics of adult respiratory distress syndrome (ARDS)

A
  1. hypoxemia

2. diffuse noncardiogenic pulmonary edema

38
Q

ARDS etiology

A

direct or indirect injury to the lungs, i.e. shock, sepsis, pneumonia, trauma, aspiration, surgery

39
Q

ARDS pathogenesis

A

decrease in amount of surfactant plus damage to alveolar-capillary membrane –> leaky capillaries

40
Q

most common source of lung cancer

A

bronchogenic – not metastatic from other places

poor prognosis

41
Q

diagnostic tools for lung cancer (3)

A

radiology, bronchoscopy, cytology

42
Q

true or false: TB manifestations are the result of hypersensitivity reaction

A

true

43
Q

restrictive lung disorders cause a period of ___ventilation, followed by chronic ___ventilation

A

hyper, hypo

44
Q

pathogenesis of dyspnea

A

restriction/obstruction –> hypoventilation –> elevated PaCO2 –> stimulation of increased respiratory rate –> restriction/obstruction prevents effective increase in RR

45
Q

first sign of respiratory failure

A

increased RR

46
Q

decrease in radius of a vessel ___ ___ resistance to flow

A

exponentially increases

47
Q

pathophysiological problem of obstructive lung disorder

A

air trapping

48
Q

normal alveolar PO2

A

100-105 mm Hg

49
Q

normal alveolar PCO2

A

40 mm Hg

50
Q

normal arterial PO2

A

90-95 mm Hg

51
Q

normal arterial PCO2

A

40 mm Hg

52
Q

normal venous PO2

A

40 mm Hg

53
Q

normal venous PCO2

A

46-47 mm Hg

54
Q

causes of left shift in oxyhemoglobin curve

A

hypothermia, alkalosis, hypocapnia

55
Q

left shift in oxyhemoglobin curve means

A

increased O2 affinity

56
Q

alveolar consolidation def

A

alveoli filling with fluid (blood, pus, water)

57
Q

pneumothorax pathogenesis

A

interruption of transmural pressure gradient between visceral and parietal pleura

58
Q

airway inflammation in asthma is characterized by ___, ___ (obstruction/restriction)

A

recurrent, reversible obstruction (narrowing)

59
Q

COPD airway inflammation is characterized by ___ (obstruction/restriction)

A

fixed obstruction (narrowing)

60
Q

smokers develop ___lobular emphysema

A

centri-

61
Q

most common origin of metastases in the lungs

A

breast

62
Q

largest lung volume

A

inspiratory reserve volume

63
Q

most important lung volume measurement for obstructive pulmonary diseases

A

FEV = forced expiratory capacity (will be low)

64
Q

normal minute lung volume at rest

A

9-10 L/min