Respiratory Flashcards
H1 blockers (first gen)
diphenhydramine, dimenhydrinate, chlorpheniramine
H1 blockers (first gen): uses
allergy, motion sickness, sleep aid
H1 blockers (first gen) : tox
sedation, antimusc, anti-alpha-adrenergic
H1 blockers (2nd gen)
(des)loratidine, fexofenadine,citirizine
H1 blockers (2nd gen): uses
allergy only
H1 blockers (2nd gen): tox
sedation, anti musc/adrenergic (but less than 1st gen)
albuterol
b2 agonist, relaxes bronchial smooth muscle. for acute exacerbation asthma
salmeterol, formoterol
long-acting for asthma, prophylaxis
theophylline
methylxantine, bronchodilation
ipatropium: mech
competitively blocs musc R’s, prevents bronchoconstriction
fluticasone, beclomethasone: use, mech
inhibits cytokines, inactivates nfKB (which increases TNF-a and other inflammatories). chronic asthma
montelukast, zafirlukast : mech, use
blocks leukotriene Rs, aspirin-induced asthma
theophylline: molecular
inhibibits PDE, decreases cAMP hydrolysis, metabolized by p450. blocks adenosine
theophylline: tox
cardio, neurotox.
salmeterol, formoterol: tox
tox: tremor, arrythmia
for COPD
ipatropium, totropium (longer acting musc antagonist)
zileuton
5-lipoxygenase path inhibitor, blocs arachidonic acid to leukotrienes
omalizaumab: mech, resistance
monoclonal anti IgE antibody, binds unbound IgE. allergic asthma. resistant to inhaled steroids, long-acting b2 agonists
guaifenesin
thins resp secretions, no suppresion of coughs
N-aceytlcysteine
loosens CF mucous plugs, acetamino OD cure
bosentan
pulmonary arterial HTN, competive antag endothelin-1 Rs, decrease pulm resistance
dextrometorphan
antag NMDA, synthetic codeine. naloxone for OD
pseudoephedrine, pheylephrine
sympatho alpha agonist, nasal decongestants
pseudoephedrine, pheylephrine: uses
open obstructed eustacchian tubes, stimulant, reduce hyperemia/edema etc
