Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > GI Drugs > Flashcards

GI Drugs Flashcards

1
Q

H2 blockers

A

-tidines, reversible block of H2 less H+ secretion by parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

proton pump inhibitors

A

-prazoles, *irreversibly* inhibit H+/K+ ATPase in parietal cells Rx: peptic ulcer, reflux, gastritis, ZE syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

bismuth, sucralfate

A

allows bicarb secretion to restore pH balance in mucous layer Rx: traveller’s diarrhea, increases ulcer healing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

cimetidine

A

p450 inhibitor antiandrogenic (gynecomastia, impotence & decreased libido, prolactin release) crosses BBB (confusion, dizziness, headaches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ranitidine, cimetidine

A

decreased renal excretion of creatinine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

misoprostol

A

PGE1 analogue (increases gastric mucosa, decreased acid production)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PPIs (tox)

A

higher risk of pneumonia, C dificile. Chronic tox: hip fractures, decrease serum Mg2+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

misoprostol

A

prevents nsaid-induced peptic ulcers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

misoprostol

A

maintains PDA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

misoprostol

A

induces labor (ripens cervix)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

misoprostol

A

contraindicated in women of childbearing age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

octreotide

A

somatostain analog. used for variceal bleeds, acromegaly, vipoma, carcinoid tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

octreotide

A

tox: nausea, craps, steatorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

antacids

A

alters gastric and urinary pH, delays gastric emptying

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

antacids

A

causes hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

aluminum hydroxide

A

tox: constipation, hyPOphosphatemia, prox muscle weakness, osteodystrophy, seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mg OH

A

diarrhea, hyporeflexia (good clue, since this ion is related to another that causes twitching aka Ca2+), hypotension, cardiac arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Ca CO3 (calcium carbonate)

A

hypercalcemia chelates and decreases effects of other drugs ie tetracycline increased rebound acid (increase in gastric acid secretion after initial buffering of antacid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

osmotic laxatives

A

Mg OH, Mg citrate, polyethylene glycol, lactulose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

lactulose

A

for hepatic encephalopathy, promotes nitrogen excretion as NH4+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

osmotic laxatives

A

for constipation. tox: diarrhea, dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

infliximab

A

TNF-a MAb for Crohn’s, UC, RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

sulfasalazine

A

combo of sulfapyridine (antibacterial) and 5-aminosalicyclic acid (anti-inflamm)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

sulfasalazine

A

activated by colonic bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

sulfasalazine

A

Tox: malaise, nausea, oligospermia (reversible)

26
Q

ondansetron

A

5-ht3 antagonist., antiemetic. tox: headache, constipation

27
Q

metoclopramide

A

D2 R antagonist. increases resting tone, contractility, lower esophageal tone, motility. no effect on colon transport time

28
Q

metoclopramide

A

rx: diabetes, post surgery gastroparesis, antiemetic

29
Q

metoclopramide

A

tox: parkinsonian. restless, drowsy /fatigue/depression, nausea, diarrhea

30
Q

metoclopramide

A

interacts with digoxin, diabetes rx

31
Q

metoclopramide

A

contraindicated in Parkinson’s, small bowel obstruction

32
Q

-tidines, reversible block of H2 less H+ secretion by parietal cells

A

H2 blockers

33
Q

-prazoles, *irreversibly* inhibit H+/K+ ATPase in parietal cells Rx: peptic ulcer, reflux, gastritis, ZE syndrome

A

proton pump inhibitors

34
Q

allows bicarb secretion to restore pH balance in mucous layer Rx: traveller’s diarrhea, increases ulcer healing

A

bismuth, sucralfate

35
Q

p450 inhibitor antiandrogenic (gynecomastia, impotence & decreased libido, prolactin release) crosses BBB (confusion, dizziness, headaches)

A

cimetidine

36
Q

decreased renal excretion of creatinine

A

ranitidine, cimetidine

37
Q

PGE1 analogue (increases gastric mucosa, decreased acid production)

A

misoprostol

38
Q

higher risk of pneumonia, C dificile. Chronic tox: hip fractures, decrease serum Mg2+

A

PPIs (tox)

39
Q

prevents nsaid-induced peptic ulcers

A

misoprostol

40
Q

maintains PDA

A

misoprostol

41
Q

induces labor (ripens cervix)

A

misoprostol

42
Q

contraindicated in women of childbearing age

A

misoprostol

43
Q

somatostain analog. used for variceal bleeds, acromegaly, vipoma, carcinoid tumors

A

octreotide

44
Q

tox: nausea, craps, steatorrhea

A

octreotide

45
Q

alters gastric and urinary pH, delays gastric emptying

A

antacids

46
Q

causes hypokalemia

A

antacids

47
Q

tox: constipation, hyPOphosphatemia, prox muscle weakness, osteodystrophy, seizures

A

aluminum hydroxide

48
Q

diarrhea, hyporeflexia (good clue, since this ion is related to another that causes twitching aka Ca2+), hypotension, cardiac arrest

A

Mg OH

49
Q

hypercalcemia chelates and decreases effects of other drugs ie tetracycline increased rebound acid (increase in gastric acid secretion after initial buffering of antacid)

A

Ca CO3 (calcium carbonate)

50
Q

Mg OH, Mg citrate, polyethylene glycol, lactulose

A

osmotic laxatives

51
Q

for hepatic encephalopathy, promotes nitrogen excretion as NH4+

A

lactulose

52
Q

for constipation. tox: diarrhea, dehydration

A

osmotic laxatives

53
Q

TNF-a MAb for Crohn’s, UC, RA

A

infliximab

54
Q

combo of sulfapyridine (antibacterial) and 5-aminosalicyclic acid (anti-inflamm)

A

sulfasalazine

55
Q

activated by colonic bacteria

A

sulfasalazine

56
Q

Tox: malaise, nausea, oligospermia (reversible)

A

sulfasalazine

57
Q

5-ht3 antagonist., antiemetic. tox: headache, constipation

A

ondansetron

58
Q

D2 R antagonist. increases resting tone, contractility, lower esophageal tone, motility. no effect on colon transport time

A

metoclopramide

59
Q

rx: diabetes, post surgery gastroparesis, antiemetic

A

metoclopramide

60
Q

tox: parkinsonian. restless, drowsy /fatigue/depression, nausea, diarrhea

A

metoclopramide

61
Q

interacts with digoxin, diabetes rx

A

metoclopramide

62
Q

contraindicated in Parkinson’s, small bowel obstruction

A

metoclopramide

Pharm (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions