Respiratory Flashcards
What is the goal of Arterial O2 sats?
> 94% (healthy patient)
COPD 88-92%
What is the goal for Arterial O2 tension (PaO2/partial pressure in vasculature)?
80mmHg
What is the PaO2/FiO2 ratio in the vented patient?
Goal of 400-500
What is the calculation for Alveolar-arterial gradient?
2.5+0.21 (RA) x AGE
What is the Alveolar-aterial gradient?
O2 in the alveoli (PAO2)
VERSUS
O2 dissolved in the plasma (PaO2)
The Alveolar-arterial gradient increases with
An increase in FiO2
What does the oxyhemoglobin Dissociation Curve tell us?
The correlation between saturated HGB with partial pressure
What causes a LEFT shift on the oxyhemoglobin dissociation curve?
LOW temp/DPG
LESS O2 delivery to TISSUES
ELEVATED pH & Affinity (O2)
FETAL
“Meth” “LEFT”
What causes a RIGHT shift on the oxyhemoglobin dissociation curve?
REDUCED O2 affinity
INCREASED O2 delivery, DPG, H+ & Temp
More acidic
When HGB has a high affinity for O2
It will hold on to it
Hypoxemia is low O2 in the
Blood
Hypoxia is low O2 in the
Tissues
Hypoventilation will cause what issues?
Increase in PaCO2 & PACO2
Decrease in PAO2 & diffusion
How can hypoxemia be corrected?
Small increases in FiO2
Ventilation is….
Oxygenation is….
Co2 out
O2 in
Examples of Low flow
NC
Simple face mask
Face tent
NRB
Examples of High Flow
HFNC
Venturi Mask
Neb
Non-invasive/invasive vent (mechanical)
What is the FiO2 & LPM of venturi & trach collar?
FiO2= 0.24-0.6
LPM= 2-15
What is the FiO2 & LPM of NC?
FiO2= 0.24-0.4
LPM= 1-6
What is the FiO2 & LPM of simple mask?
FiO2= 0.35-0.55
LPM= 5-10
What is the FiO2 & LPM of NRB?
FiO2= 0.80-0.95
LPM= 10-15
FiO2 will increase by what percent per liter of O2?
4%
NRB is ideal for
Severely hypoxic, but ventilating well
Venturi is good for
COPD
Pre-oxygenation is known as
Denitrogenation
When we pre-oxygenate, our reserved is increased by
1.5-4L
What is the 2nd biggest reservoir of O2 besides the plasma?
FRC, which is the lung volume held after exhalation
What is the targeted end tidal O2?
90%, but most likely 88-92%
Where should FiO2 be to prevent hyperoxia?
40-50%
Hyperoxia can cause
Pulmonary/CNS/Ocular toxicity
Pro-inflammatory & cytotoxic effects
Will an increase in FiO2 help a patient hemmoraging?
NO
In HOTN, 100% O2 will cause
A reduce in SV & CO through an increase in SVR
100% O2 in cardiac ischemia can increase
Coronary vasoconstriction
100% O2 in cerebral ischemia can cause
A decrease in CBF
What system controls the airway?
PSNS by affecting the size, gland activity & microvasculature
What receptors are on the airway smooth muscle?
Adrenergic & an abundance of Beta 2 receptors (postgang/cholinergic)
SNS has this effect on airway smooth muscle
Indirect control
The NANC has this influence on smooth muscle tone
Direct
The NANC has a role in
The inflammatory process
What cells cause bronchoconstriction?
Histamine
Prostaglandin D2 & F2
Leukotrienes C4, E4 & D4
Platelet activating factor
Bradykinin
What preganglionic and postganglionic receptors are involved in PSNS influence?
Vagus pregang
Cholinergic postgang
How does contraction occur in the airway smooth muscle when the PSNS system is activated?
Vagus pregang–> Cholinergic post gang–>
ACh–>M3–>Gq (stimulatory)
Phospholipase C–> Increased IP3
SR releases Ca+–>MLCK activated
Which C fibers cause bronchoconstriction?
Sub P
NKa
Calcitonin gene related peptide
Catecholamine release can
Bind Beta-2 receptors indirectly through the SNS
Beta 2 during SNS activation will
Inhibit the release of ACh by causing hyperpolarization and stimulating adenyl cyclase, which increases cAMP & causes smooth muscle relaxation
cAMP in the smooth muscle will cause
Relaxation
Beta 2 stimulated which G protein?
Gs, which increases cAMP, which also created hyperpolarization, leading to HYPOKALEMIA
In the NANC system, what is inhibitory & what is excitatory?
Inhibitory- Nitric Oxide & Vasoactive Intestinal Peptide
Excitatory- Sub P & NKa
M2 involves which G protein?
Gi, which inhibits adenyl cyclase, leading to NO increase in cAMP, causing constriction
Asthma will cause these changes
Hyper-irritability
Airway remodeling
Mucous
Hypertrophy
Angiogenesis
Decrease in diameter & airflow
Increase in resistance
What are the long term effects of Asthma?
Epithelial damage
Submucosal edema
Mucous secretion/plugging
Increase in vascular permeability
Vasoconstriction
Definition of COPD
Chronic Obstructive Pulmonary disease where expiratory airflow limitations are NOT fully reversible
COPD can be classified as
Emphysema
Chronic Bronchitis
Characteristics of Emphysema
Parenchymal destruction
Loss of elastic recoil & structural integrity
Characteristics of Chronic Bronchitis
Small airway narrowing & inflammation
Mucous
COPD will cause
Bronchial inflammation
Fibrosis & narrowing
Goblet cell metaplasia
Mucous hypersecretion
Alveolar destruction (emphysema)
Decrease in elastic recoil & airflow
increased resistance
Patients with COPD often
Air-trap
Hyperinflate
What can be causing a bronchospams?
Anaphylaxis to ABX or NMB
Mechanical?
Histamine release (atracurium, meperidine or morphine)
Hyperactive airway
What will you see with a bronchospasm?
Increase in peak airway pressures (Early)
Decrease in tidal volume (early)
Capnography changes (early)
Changes in SaO2 & PaCO2
What will you feel or hear with a bronchospasm?
Difficult to bag
Wheezing
What is a poor indicator of airway obstruction?
Wheezing
Increased levels of cAMP cause
Inhibition of MLCK
What are examples of Inhaled short acting Beta 2 agonists?
Albuterol
Levalbuterol
What are examples of inhaled long acting Beta 2 agonist?
Salmeterol
Formoterol
What are examples of IV Beta agonists? Think IV SET
Salbutamol
Epinephrine
Terbutaline
Beta agonists will cause dilation & relaxation. They will also cause
Decrease in diastolic pressure 9SVR)
Hepatic glycogenolysis
Pancreatic release of glucagon
Stimulates Na/K ATPase (hypokalemia)
What are the systemic side effects of Beta agonists?
Tremor
Tachycardia
HYPERglycemia
HYPOkalemia
HYPOmagnesium
Decrease in PaO2 (by vasodilating poorly vented areas=shunting)
Careful giving Beta. 2 agonists to
Cards
DM
Hyperthyroid
Diuretic
Digoxin
Albuterol has some
Beta 1 activity
What is airway onset of albuterol?
5-10min
What is the PO inhaler onset of albuterol?
15-30min
What is the duration of albuterol?
4-6 hours
What is the acute dose of albuterol?
4-8 puffs Q20min
90mcg/puff
Epi has both
Beta 1 & Beta 2 effects
What is the dose of Racemic EPI
0.5mL of 2.25% in 4mL NS
Improvement in 20-30min
Monitor of systemic effects
Vasoconstriction in tracheal mucosa
Relieves edema
Muscarinic Antagonists (anticholinergics) block
ACh from binding M3, which binds to Gq, cascading with Phospholipase C, increasing the formation of IP3, causing constriction
Which Muscarinic Antagonists (anticholinergic) is inhaled & long acting?
Tiotropium
Which Muscarinic Antagonists (anticholinergic) is inhaled & short acting?
Ipratropium (tx COPD)
Which Muscarinic Antagonists (anticholinergic) are given IV?
Atropine (crosses BBB)
Glycopyrrolate
Anticholinergic side effects?
Tachycardia
Dry mouth
Blurred vision
Mydriasis
Urinary retention
Tremors
What is the example of Methylxanthines?
Theophylline
What are the 2 MOA of Theophylline, a Methylxanthine?
Phosphodiesterase Inhibitor (increased cAMP)
Blocks Adenosine 2B receptor
What are the side effects Theophylline, a Methylxanthine?
GI upset
HA
Restlessness
Seizures
Arrhythmias
Death
Toxic >20mcg/mL
Corticosteroids effects
DNA transcription & proteins
Glucocorticoids increase
Beta 2 receptors
Glucocorticoids decrease
Inflammatory cells
Mucus Secretion
Cytokine
Leak
Steroid & beta agonist combination therapy is reserved for
COPD
What are the combo drug examples of corticosteroids & beta 2 agonists?
Fluticasone/Salmeterol
Budesonide/Formoterol
What are examples of Corticosteroids used to treat respiratory problems?
Fluticasone
Mometasone
Methylprednisolone…
What are the side effects of corticosteroids?
Infection
HYPERglycemia
HTN
Adrenal Suppression
Psychosis
Ulcer
Osteoporosis
Increased IOP
What are examples of Leukotriene Modifiers?
Montelukast
Zileuton
What is the MOA of Leukotriene Modifiers?
Blocks Leukotriene receptors
Blocks conversion of arachidonic acid to leukotrienes
What are the examples of Mast cell stabilizers?
Cromolyn Sodium
Nedocromil
What is the MOA of Mast cell stabilizers?
Blocks mast cell degranulation
Blocks release of histamine, bronchoconstriction, mucosal edema & mucous secretion
Which medications DO NOT decrease bronchomotor tone?
Desflurane
Nitrous Oxide
Which channels are sensitive to anesthesia?
T-type Ca+ channels
Beta 2 are bound to…
Alpha 2 are bound to…
Beta-Gs
Alpha- Gi
What is bound to Gq?
Alpha 1
ET-A
M3
What happens when Alpha1, ET-A & M3 are bound to Gq proteins?
IPs increases, increasing the release of intracellular Ca+= constriction
Activated Ca+ in the endothelial cell will eventually lead to
Vasodilation
What is the pathway of cGMP?
Ca+–>NOS–>L-arg–>NO
Activation of guanylyl cyclase–> GTP to cGMP= relaxation
cGMP activates
MLCP, which breaks down myosin light chains
What is the mean pulmonary artery pressure?
> 20-25mmHg
Increased Pulm vascular resistance
> 2 Woods units
Normal mean PAP
12 (or less than 20)
Normal PVR
Anything <2
What is the pathology of PH?
Decreased NOS & prostacyclin
Increase in thromboxane & endothelin-1
When dealing with PH, it is important to avoid
PVR
Hypothermia
Ketamine
Nitrous Oxide
Acidosis
Lrg decreases in SVR
What should be used in the management of PH?
Vasopressors intra-op for HOTN
Etomidate
Opioids
Low volatile agents
In PH, there is a decrease in
The blood flow to the right side
What is the main treatment for acute PH?
Inhaled Nitric Oxide
Inhaled Nitric Oxide activates
Guanyl cyclase to increase cGMP
Inhaled Nitric Oxide reduces
Shunt fraction
IV Nitric oxide causes
Vasodilation everywhere, which can lead to perfusion of poorly vented lungs, which will increase the shunt and decrease PaO2, PVR & SVR (hypoxemia)
Nitric Oxide will cause
Vasodilation
Bronchodilation
Anti thrombotic/inflammatory/proliferation
What are examples of Phosphodiesterase Inhibitors?
Milrinone (PDE3/cardiac)
Sildenafil (PDE5/lungs)
Tadalafil (PDE5/lungs)
What is the MOA of Phosphodiesterase Inhibitors?
Increases & prevents the breakdown of cGMP & cAMP
Targets Nitric Oxide pathway
Ca+ levels are decreased
Inhibits Phosphodiesterase enzymes
PDE5 side effects
HA
Nasal congestion
Dyspepsia
Flushing
Priapism
PDE-4 side effects
HA
Nausea
Diarrhea
PDE3 side effects
V Arrythmias
HA
HOTN
What are examples of Endothelin Receptor Antagonists?
Bosentan
Ambrisentan
What is the MOA of Endothelin Receptor Antagonists?
Blocks ET-A &/or ET-B
Decreases smooth muscle cell proliferation
Endothelin Receptor Antagonists side effects
Related to vasodilatory properties
Flushing
HA
HOTN
What is the MOA of Prostacyclin derivatives/ Prostaglandins?
Increases PGI2 to target IP receptors
Relaxes vascular smooth muscle
Inhibits muscle cell growth 7 PLT aggregation
Prostacyclin derivatives/ Prostaglandins improves
Oxygenation
Prostacyclin derivatives/ Prostaglandins drug examples
Prostacyclin
Epoprostenol (inhaled)
Iloprost (inhaled)
Trepostinil (inhaled)
Remodulin (IV)