Respiration Flashcards
What is the effect of alkalosis on the CNS?
Overstimulation, which can lead to tremors.
What is the effect of acidosis on the CNS?
Depression, leading to coma and death.
What is the difference between type 1 and type 2 respiratory failure?
Type I respiratory failure involves low oxygen, and normal or low carbon dioxide levels. It is usually due to a mismatch in ventilation and perfusion.
Type II respiratory failure involves low oxygen, with high carbon dioxide. It is usually due to hypoventilation of the alveoli.
What is the difference between obstructive and restrictive pulmonary disease?
Obstructive means there is something blocking the bronchioles which makes it harder to expire the air in the chest. Forced vital capacity will not really decrease but FEV1 will significantly, so that the FEV1/FVC ratio decreases.
Restrictive means there is a decrease in compliance of the lungs so it is harder to fill the lungs with air. The FVC and FEV1 will both decrease so there will be little or no change in the FEV1/FVC ratio.
Define compliance.
The ease with which the lungs expand and contract.
Compliance is the measure of distensibility of matter and specifies the ease with which matter can be stretched or distorted.
It equals a change in volume per unit change in pressure. (Change in volume/Change in pressure.)
What factors affect compliance?
The connective tissue structure of the lungs, the production of surfactant by type 2 pneumocytes, the mobility of the ribs.
What happens if the chest wall is punctured?
Pneumothorax (air rushing into pleural cavity) which increases the pressure in the pleural cavity, causing atelectasis (collapsed lung).
Does a decrease in blood pH stimulate the central chemoreceptors to increase ventilation?
No, H+ ions can’t cross the blood-brain barrier, only C02 can, so there would have to be an increase in blood pCO2 to decrease the pH in CSF and stimulate central chemoreceptors.
Therefore, only the peripheral chemoreceptors are stimulated in respiratory compensation.
Which structures contribute to the fully developed diaphragm?
Septum transversum, myoblasts from the mesoderm of the body wall, pleuroperitoneal folds, dorsal mesentery (of the oesophagus).
How does compliance relate to the elastic recoil of the lungs?
Compliance is inversely proportional to elastic recoil.
What is forced vital capacity?
The volume of gas from deepest inspiration to deepest expiration.
What is FEV1?
The maximum volume of air that can be forcibly expired in the first second after deepest inspiration.
What happens to the pO2 in the blood after haemorrhage (the amount of haemoglobin in the blood has decreased)?
The pO2 will be unchanged.
What are the main sites of the baroreceptors that detect increased blood pressure?
Aortic arch and carotid sinuses.
Why does the residual volume increase slightly in acute asthma?
It is an obstructive disease and so there is difficulty in expiration caused by bronchoconstriction.
What happens to the FRC (functional residual capacity) in obstructive diseases and restrictive diseases?
In obstructive diseases, the FRC is increased.
In restrictive diseases (like obesity) and with age, the FRC is reduced.
What is the medical term for coughing up blood?
Haemoptysis.
What do the waves on the biphasic jugular venous waveform mean?
a wave = Atria contract
c wave = Cystole begins (tricuspid prolapse)
x wave = atria relaX
v wave = Ventricles prepare yourselves (atria filling)
y wave = trYcuspid opens
What’s the difference between conducting and respiratory parts of the respiratory tract?
Conducting = cartilage in wall, cleanse and warm and humidify air so it's ready for gas exchange Respiratory = soft wall, site of gas exchange, terminal bronchioles and alveoli and alveolar ducts.
What is the purpose of the dorsal respiratory group in the medullary respiratory centre?
To generate impulses to diaphragm and external intercostals in 2 second bursts during normal quiet breathing. Inactive during forceful exhalation.
What is the purpose of the ventral respiratory group in the medullary respiratory centre?
Pre-Botzinger complex acts as a pacemaker and sets breathing rhythm by determining the rate of DRG firing impulses.
Other VRG neurones are only activated in forceful breathing - innervate accessory muscles of respiration (sternocleidomastoid, scalenes, trapezius, internal intercostals, abdominal muscles)
What is the difference between the peripheral and central chemoreceptors?
The peripheral chemoreceptors are in the carotid bodies and aortic bodies, and can detect [H+], pO2, pCO2 in the blood.
The central chemoreceptors are in the medulla oblongata and detect changed in pH of CSF cause by changes in pCO2.