resp cancer Flashcards
where is small cell lung cancer located
centrally, near the main bronchus
what is a risk factor for small cell lung cancer
smoking
what do small cell lung cancers secrete
ACTH and ADH
what does ACTH cause
cushings syndrom
what does ADH cause
increased water retention and increased BP
what lung cancer has the worst progosis
small cell
what are the non small cell lung cancers
squamous cellcarcinoma, adenocarcinoma, large cell, bronchial carcinoid
where are squamous cell lung cancers found
centrally located
what are risk factors for squmaous cells
smoking
what do squamous cell lung cancers secrete
PTH
what does PTH cause
hypercalaemia (brittle bones)
are sqaumous cells cavitating
yeeez
where are adenocarcinomas found
peripherally
who gets adenocarcinomas
non smokers
what do adenocarcinomas secrete
TTF
what gene is associated with adenocarcinomas
EGFR
what tumour can form pancoast tumours
squamous and adenocarcinoma
where are large cells found
throughout (peripherally)
are large cells well or poorly differentiated
poorly
what are some paraneoplastic features of lung cancer
finger clubbin hypertrophic pulmonary osteoarthropathy - HPOA thrombophelbitis hypercalaemia SiADH eaton-lambert syndrome
what is HPOA
pain and tenderness of long bone due to elevation of peritoneum away from bone surface
what is HPOA assocaited with
squamous cell
what is thrombophelbitis
coagulability of blood in cancer patients eg painful saphenous vein
what is hypercalcaemia
stones, ones, moans and phsychiatric overtones
what is hypercalcaemaia related to
squamous cell
