Resp Flashcards
PE in pneumothorax
No tactile fremitus
Hypertesonance percussion
Decreased breath sound on affected side
Tracheal deviation away from side
Dx of pneumothorax
CXR
Most effective Rx in sleep apnea?
CPAP
Population of hyperventilation syndrome
Young women
Sx of hyperventilation
Tachypnea Hyperpnoea (deep breath) Atypical chest pain Tachycardia \+/- carpopedal spasm
Gas:
Resp alkalosis
Bronchitis vs bronchiactesis sputum
Bronchitis > mucoid sputum
Bronchiactsis > purulent malodorous sputum
Rx of pneumothorax <20%
Outpatient observation
CXR in 24-48 hr
Or
Oxygen + observe
Tests done for sarcoidosis patients
Slit lamp Pulmonary function test Serum Ca ECG ACE level
Sleep apnea associations
HTN
Differentiate bronchitis from emphysema by PFT?
Single diffusion capacity DLCO.
Most effective measure in COPD?
Smoking cessation
What Rx measure improves mortality / survival in COPD
Supplemental O2
If asthma isn’t controlled with inhaled SABA?
Add low dose ICS > increasing dose of SABA
Good pasture’s classic?
Acute glomerulonephritis
Pulmonary hemorrhage
Following URTI
Cause of glumeruonephritis in goodpasture
Anti-GBM antibodies > complement activation > tissue damage.
CXR in asbestosis
Lower > upper lobe
Fibrosis w/ linear streaking (early)
Cyst & honeycombing (late)
IMP > plural & diaphragmatic calcification
Cancer with asbestosis
Bronchogenic Ca
Mesothelioma
When does SABA work?
Work in 5 minutes for 4-6 HR.
Inhaled CS before SABA improves delivery?
False
Which is better in asthma oral Beta agonists or inhaled SABA
Inhaled
Exercise induced bronchoconstriction classic
10% decrease in FEV1 with exercise.
High-ventilation sports > track, skiing
Winter sports
Dx exercise induced bronchocostriction.
Trial with albutrol inhaler.
Best way to Dx COPD?
Spirometer FEV1/FVC < 70% - 80%
Is clubbing a sign of COPD?
No
Guidelines for pulmonary nodule.
Suspicious: 1. Size < 8 mm 2. Ground glass appearance 3. Irregular borders 4. Double size in 1 mo - 1 yr 5. Hx of Ca 6. Smoker => biopsy.
Non suspicious:
Repeat CT in 6-8 mo
Rx of tension pneumothorax
Needle at 2nd intercostal space > chest tube > CXR.
Contraindications to thrombolytics?
Eye / CNS surgery in 2 wk Brain tumor Brain vascular disease Stroke < 2 mo Active bleeding Hypotension
When does rapidly progressive silicosis develop?
6 months of exposure.
Benefit of BiPAP in acute COPD
Improves ventilation
Delay intubation
Improves mortality / morbidity.
Rx of acute chronic bronchitis.
SABA
Anti cholinergic
Steroids (oral / IV)
Resp side effect of nitrofurantoin?
If used > 6 mo
Restrictive pulmonary fibrosis
Risk of tension pneumothorax
Patient on +ve mechanical ventilation.
Step after pulmonary function test?
Full pulmonary test for static lung volume
COPD ventilation setting
Volume assist Rate: 10-12 TV: 8mL/kg PEEP 0-5 cm H2O Hgb sat: 92% Peak flow 75-90 L/min
Gold standard Dx in PE?
CT Angio
Hypersensitivity pneumonitis cause
Inhaled organic dust
E.g mold
Hypersensitivity pneumonitis classic
4-8 hrs after exposure > chill, cough, SOB worsen with time
Symptoms resolve then recur suddenly with repeated exposure.
CXR and labs in hypersensitivity pneumonitis
CXR = normal
PFT = restrictive
High ESR
High IgG
Idiopathic pulmonary fibrosis classic
Gradual Sx
Dry cough
Clubbing
Fine bilateral crackles (Velcro crackles)
Causes of transudate pulmonary effusion
CHF
Cirrhosis
Low albumin
Nephrotic syndrome has
Causes of exudative plural effusion.
Pneumonia Malignancy PE Viral infection TB
What’s central sleep apnea
Cessation of airflow 10 seconds without resp effort result in unstable resp control center
What worsens central sleep apnea
- Low CO2: high altitude, cheyne-stroke
2. Slow circulation: CHF
Role of sedatives in central sleep apnea
Helpful
Indication of sever apnea?
Apnea-hypopnea index > 29
1st line Rx in sever sleep apnea?
CPAP
Acute resp alkalosis acid-base labs
PH > 7.45
O2 normal
CO2 < 40
Anaerobic lung abscess classic
Risk of aspiration
Productive cough + fever
Poor dental hygiene
Bad mouth odor + sputum odor.
CBC changes in COPD? Why?
Increased RBC mass + erythropoietin
=> low O2 stimulates bone marrow => secondary polycythemia
What’s pulsus paradoxus? What does it indicate?
10 mmHg decrease in SBP on inspiration
Asthma
How to assess severity of asthma attack?
- Mild:
O2 > 94%
PEF 70% expected - Moderate:
O2 < 90
PEF < 40% expected
Pulsus pardoxus - Sever:
PEF < 25% expected
Rx of acute asthma attack?
Inhaled SABA
Prednisolone (oral / IV)
O2 supplement given if O2 < 90%
Def of sleep apnea
> 5 obstructive events / hr
Daytime sleepiness
Sleep apnea association
Obesity
Older age
MEN
HTN
Overflow fecal incontinence classic
Common in institutionalized elderly due to constipation meds.
Cause of reduced storage fecal incontinence
IBD
Hereditary theombophilia
Factor V Leiden Prothrombin 20210A Protein C Protein S Antithrombin deficiency
Most common hereditary thrombophilia
Factor V Leiden
Rx of PE
Heparin 3-7 days
Warfarin 6 months
INR 2-3
When to use tPA in PE
Patient with low BP
Role of anti-thrombin in PE?
Prophylaxis pre or post op
What does flat inspiratory loop indicate
Extra-thoracic pulmonary obstruction
What to r/o in asthma not responsive to Rx?
Vocal cord dysfunction
Vocal cord dysfunction classic
Episodic tightness of throat
SOB
Choking sensation
Cough
Dx vocal cord dysfunction
Fiber optic laryngoscope
=> paradoxical inspiratory movement +/- expiratory partial closure of cords.
Rx of vocal cord dysfunction
Speech therapy
Breathing techniques
Cause of vocal cord dysfunction
Occupational exposure (glutaraldehyde + chloride in swimmers) Psychological stress
Rx of sarcoidosis limited to hilar lymphadenopathy
Observation
Role of Na cromolyn in asthma attack
No role
Used in prophylaxis.
Blood gases in PE
High A-a gradient
PH > 7.45
CO2 < 40
O2 low
Resp alkalosis
Sarcoidosis Rx
Observation
Prednisolone (1st)
MTX (2nd)
Garland’s triad
Sarcoidosis
- Bilateral hilar LN
- rt paratracheal LN
Stages of sarcoidosis
0: normal CXR
1: lymphadenopathy
2: LN + lung disease
3: lung disease only
4: fibrosis.
Cause of silicosis
Crystalline-free silica inhalation form cement.
Causes of resp alkalosis
Fever
Low O2
Salicylate
Tachypnea
Spirometer in asthma
Reduced FEV1
Reduced FEV1/FVC
Restrictive pattern on spirometer
Low FVC
Low FEV1 < 70%
Normal or high FEV1/FVC
Drugs cause pulmonary fibrosis
Amiodrone
Amphotericin B
Acebutolol
Carbamazepine
Investigations of dysphagia
Barium swallow
Manometer and
Which is more effective in acute COPD:
Albuterol or levalbuterol?
Same
Which is better during acute COPD oral or IV steroids
Same.
MCC of chronic cough (order)
- Upper airway cough = Postnasal drip
- Asthma
- GERD
Rx steps in acute asthma
- SABA
- Systemic steroids
- Ipratropium
- Admit if no response in 4-6 hrs.
Dx bronchiectesis
HRCT
CXR in bronchiectasis
PeriBronchial thickening (tram track)
Increased vascular markings
Period of cough in acute bronchitis
20 days (> 2wk)
MCC of acute bronchitis
Viral infection
Purulent sputum in acute bronchitis indicates?
Airway desquamation
MCC of 2ry spontaneous pneumothorax
COPD
Pleuropulomnary nocardiosis classic
In immunocompromised
Sx: night sweat, fever, cough.
CXR: multiple infiltrates.
No response to pneumonia Rx
Dx nocardia?
Modified AFB => fire-faraco stain.
Weakly positive on AFB
Rx of nocardia
Sulfonamides => sulfasalazine or TMP/SMX
Pneumocystis vs nocardia?
Both give same finding
Stain:
Pneumocystis doesn’t stain AFB, stains silver.
Nocardia is weakly positive in AFB + stains w/ fite-faraco
Rx of coccidioides immits
Ketoconazole
1st step in tension pneumothorax
Needle Thoracentesis
Then chest tube.
Red flags in hiccups
> 2 days
Waking patient from sleep
Military TB on CXR
Diffuse small nodules
ECG finding in PE
S1Q3T3
McGinn-White sign
S1Q3T3 on ECG
Indicates Rt heart strain
High mountain sickness classic
8-96 HR of arrival Headache Poor sleep N/V Anorexia
Rx acute mountain sickness
Prevention = slow ascent, high carb diet or acetazolamide.
1- Slow descent
Oxygen
Hydration
2- Hyperbaric chamber
3- Acetazolamide
Dexamethasone
What’s acetazolamide
Carbonic anhydrase inhibitor
Cuz metabolic acidosis via loss of HCO3
Rx of acute COPD
ABC O2 Bronchodilator neb Systemic steroids (IV soulmedrol) Abx: doxy, TMP/SMZ, amoxi/clavu
Causes of increased A-a
Alveolar collapse (atelectasis)
Pneumonia
PE
Intracardiac shunt
Vascular shunt
Asthma
COPD
ILD
Pulmonary vascular Dz
Spirometer in vocal cord dysfunction
Flat inspiratory flow volume loop
Normal exploratory
Exposure to asbestosis
Ship yards
Asbestosis Classic
Dyspnea
Dry cough
Basal velcro crackles
PFT in asbestosis
Restrictive
CXR of adenocarcinoma
Peripheral lung nodules
Mesothelioma on CXR
Obliteration of diaphragm
Modular thickening of pleura
Sheet like encasement of pleura.
Drugs contraindicated w/ mountain sickness
Diuretics
BB
Major issue w/ CPAP in sleep apnea
Compliance
Spirometer value affected by age?
FEV1/FVC
Increased Functional residual capacity
Low vital capacity
Normal total lung capacity
T/F: spirometer doesn’t measure airway dimensions
T
What’s antifreeze
Ethylene glycol
Ethylene glycol ingestion causes what?
Metabolic acidosis.
Corticosteroids for COPD
No effect on mortality
Reduce exacerbation
No risk of cataract or fracture
Risk of candida
Feature of malignant pulmonary nodule
> 10mm Irregular borders Ground glass No calcification or eccentric calcification Double in 1 mo - 1 year
ARDS Rx
Oxygen (mask or ventilator)
Lights criteria (transudate vs exudate)
Fluid/serum ratio of protein + LDH
LDH fluid/serum > 0.6
Protein fluid/serum > 0.5
=> exudate
MCC of hemoptysis
Lower RTI
ILD vs bronchiactsis if clubbing present?
ILD = fine crackles Bronchiactsis = coarse
Lung abscess CXR
Cavity w/ necrotic debris
MCC of aspiration lung abscess
Post op from aspiration
Rx of lung abscess
Clindamycin
Pleuritic rub in PE indicates?
Pleural infarction
Pleural effusion classic
Decreased breath sounds
Decreased fremitus
Dull percussion
Tracheal deviation to opposite site.
Bronchiotis obliterans seen w/?
Lung + BM transplant
Bronchiolitis obliterans CXR
Hyperlucency
V/Q scan in bronchiactsis obliterans
Moth-eaten
PFT in bronchiolitis obliterans
Low FEV1
Normal DLCO
Stages of CO toxicity
HbCO < 20%
Headache, dizziness, blurry vision.
HbCO 20-40%
Confusion, syncope, chest pain, rhabdomyolysis
HbCO 41-60%
Arrhythmia, low BP, MI, seizure
HbCO >60%
Death
CO toxicity Rx
Stop exposure
Oxygen (non-rebreather)
CarboxyHgb level.
Decide level of CO toxicity
Carboxy-Hgb level
When to use hyperbaric oxygen in CO toxicity
Moderate to sever control
Carboxy-Hgb > 20%
Drug contraindicated in asthma? Why
Non selective BB
Cause constriction
Palliative Rx for patients on death rattle?
Anti cholinergic to decrease secretions
E.g. Glycopyrrolate
Rx pulmonary edema
- Preload reducers:
Diuretics = furosemide - Morphine:
Rx cardiac pulmonary edema
To decrease catecholamines + SVR. - After load reducers:
Nitroprusside (pre + after load)
Enalapril (after load, SV, CO)
Theophylline toxicity classic
When > 20 mcg/ml High HR N/V + diarrhea Irritability, restlessness Agitated maniac behavior Thirst Muscle twitch
Use of peak flow in asthma
Monitor not Dx
Rx of cardiac pulmonary edema
ABC
1. Preload reduction
Nitroglycerin (most effective)
- After load
ACEI - +/- inotropic support
Rx of status asthmaticus
SABA
Hydration
IV steroids
+/- intubation
Which is better in acute asthma meter dose inhaler or nebulizer? Why?
Inhalers
- Greater improvement in peak flow rate
- Better blood gases
- Lower cost, hospital stay.
- Lower relapse.
- No difference in hospital admission rate.