Resisting Cell Death Flashcards
1
Q
Examples of factors that contribute to P53 activation
A
Replicative stress
DNA damage
Oxidative stress
Hypoxia
Nutrient deprivation
2
Q
What does activated P53 cause?
A
Senescence
Apoptosis
Cell cycle inhibition
DNA repair
Autophagy- (recycling old cell parts)
3
Q
What does activated P53 inhibit?
A
Inhibits metabolic reprogramming
Inhibits Invasion and metastasis
4
Q
How does P53 inhibit cell cycle?
A
Cell cycle arrest by activating P21 which inactivates CDK/cyclin complexes
Allows for cell repair
5
Q
How does P53 induce apoptosis?
A
- Inhibits BCL-2 (pro-survival protein)
- Activates BAX (cell death effector)
- BAX causes mitochondrial membrane to release cytochrome C
- Cytochrome C triggers Caspase-3 activation
- Leads to cell dismantling
6
Q
What viral proteins can deactivate P53?
A
HPV
Hepatitis B
Adenovirus
7
Q
How does BAX work?
A
- BAX causes mitochondrial membrane to release cytochrome C
- Cytochrome C triggers Caspase-3 activation
- Leads to cell dismantling
8
Q
Summary of Resisting cell death
A
Mutated P53 means cell can’t detect when it should die
