Enabling Replicative Immortality Flashcards
1
Q
What is the Hayflick Limit
A
Normal cells divide 20-70 times
It is a replicative cellular senescence
2
Q
What are telomeres?
A
Repetitive protective caps at end of chromosomes in DNA
Prevents damage during replication
3
Q
Crisis point
A
cell identifies DNA damage
senescence/ death
4
Q
How does Telomerase cause Immortilisation?
A
present in most tumours
Adds DNA sequences onto telomeres
This bypasses crisis point
IMMORTILISATION
5
Q
Summary of Enabling Replicative Immortality
A
Cell can replicate forever due to telomerase
