Resistance Mechanisms Flashcards
1
Q
Penicillin/cephalosporins?
A
1) B-lactamase cleavage of B-lactam ring
2) Altered PBP in cases of MRSA or penicillin-resistant S. pneumonia
2
Q
Aminoglycosides?
A
1) Acetylation
2) Adenylation
3) Phosphorylation
3
Q
Vancomycin?
A
Terminal D-ala of cell wall component replaced with D-lac, decreased affinity
4
Q
Tetracyclines?
A
Decreased uptake into cells or increased transport out of cell by plasmid-encoded transport pumps
5
Q
Chloramphenicol?
A
Plasmid-encoded acetyltransferase that inactivates drug
6
Q
Macrolides?
A
Methylation of 23S rRNA binding site
7
Q
Sulfonamides?
A
Altered bacterial dihydropteroate synthetase), decreased uptake, or increased PABA synthesis
8
Q
Quinolones?
A
Altered gyrase, plasmid-mediated resistance, efflux pumps
