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Microbiology > Bugs with Exotoxins > Flashcards

Bugs with Exotoxins Flashcards

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Biology 101 flashcards
1
Q

Bugs with ADP ribosylating A-B toxin?

A

Pertussis, ETEC (heat labile), Cholera, Exotoxin A (Pseudomonas), Diphtheria (PECED)

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2
Q

Exotoxin A?

A

Pseudomonas, Strep pyogenes

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3
Q

Inactivates EF-2?

A

Diphtheria, Pseudomonas

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4
Q

MOA of shiga toxin/shiga-like toxin?

A

Inactivates 60S ribosome by removing adenine from rRNA

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5
Q

Causes HUS?

A

Shiga toxin and shiga-like toxin

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6
Q

Shiga-like toxin?

A

EHEC

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7
Q

Difference bt Shigella and EHEC

A

Shigella invades host cells, EHEC does not

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8
Q

Bugs inhibiting protein synthesis?

A

Shigella, Pseudomonas, EHEC, Corynebacterium (SPEC)

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9
Q

Has both heat-labile and heat-stable toxin?

A

ETEC

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10
Q

MOA of heat-labile toxin?

A

Overactivates adenylate cyclase increasing cAMP, increasing Cl secretion and gut and H2O efflux

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11
Q

MOA of heat-stable toxin?

A

Overactivates guanylate cyclase increasing cGMP, decreasing resorption of NaCl and H2O in gut

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12
Q

Edema factor?

A

Bacillus anthracis

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13
Q

MOA of edema factor?

A

Mimics adenylate cyclase EZ increasing cAMP

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14
Q

MOA of cholera toxin?

A

Overactivates adenylate cyclase increasing cAMP by permanently activating Gs, increasing Cl secretion in gut and H2O efflux

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15
Q

MOA of pertussis toxin?

A

Overactivates adenylate cyclase increasing cAMP by disabling Gi, impairing phagocytosis to permit survival of microbe

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16
Q

Bugs increasing fluid secretion?

A

ETEC, B. anthracis, V. cholera

17
Q

Bug inhibiting phagocytic activity?

A

Bordetella pertussis

18
Q

Cleaves SNARE protein required for NT released?

A

Tetanospasmin and botulinum toxin

19
Q

MOA of tetanospasmin?

A

Prevents release of inhibitory (GABA and glycine) NTs in spinal cord

20
Q

MOA of botulinum toxin?

A

Prevents release of ACh at NMJ

21
Q

Bugs inhibiting NT release?

A

Clostridium tetani and botulinum

22
Q

Bugs that lyse cell membranes?

A

Clostridium perfringens and Strep pyogenes

23
Q

Alpha toxin?

A

Clostridium perfringens

24
Q

Strep pyogenes toxin?

A

Streptolysin O

25
Q

Phospholipase that degrades tissue and cell membranes?

A

Clostridium perfringens

26
Q

MOA of streptolysin O?

A

Protein that degrades cell membrane

27
Q

“Double zone” of hemolysis on blood agar?

A

C. perfringens

28
Q

TSST-1?

A

Staph aureus

29
Q

Bugs with superantigens causing shock?

A

Staph aureus and Strep pyogenes

30
Q

MOA of TSST-1 and exotoxin A?

A

Bring MHC II and TCR in proximity to outside of Ag binding site to cause overwhelming release of IFN-g and IL-2, causing shock

31
Q

A component of ADP-ribosylating toxin?

A

Active component that attaches ADP-ribosyl to disrupt host cell proteins

32
Q

B component of ADP-ribosylating toxin?

A

Binding component, enabling endocytosis

Microbiology (11 decks)

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