Research methods Flashcards

1
Q

What is a type I error?

A

Finding an association that does not exist.

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2
Q

What is a type II error?

A

Finding no association when an association actually does exist.

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3
Q

What is colinearity?

A

When two explanatory variables are highly correlated

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4
Q

What is colinearity?

A

When two explanatory variables are highly correlated

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5
Q

What are confounding variables?

A

Two explanatory variables which are both related to the outcome of each other.

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6
Q

What is an explanatory variable?

A

Independent variable.

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7
Q

What is an observational study? What are the three types of observational study?

A

Observe exposure and outcome in different groups.

  • Cohort study= following X and Y groups until something happens.
  • Cross sectional study=collecting data all from one time point.
  • Case control study= retrospectively analysing what one group was exposed to more than the control.
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8
Q

What is an experimental study? What is one benefit of using an experimental study?

A

Manipulating variables of interest and observing the outcome.

It allows us to see causality, this can never be seen with observational studies.

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9
Q

Statistically speaking, why should we use replication in our studies?

A

A larger sample size/ study being done more times and more data being collected increases the power to detect important increases/ decreases/changes.

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10
Q

What is the power value we use that is equivalent to a 95% confidence interval?

A

0.8

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11
Q

What does a power value of 0.8 mean?/ How can we interpret this?

A

We are 80% sure that there has been no type II error (finding no association when there actually is an association).

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12
Q

What is done in a retrospective study?

A

Comparing control groups with people with a group of people with an outcome of interest.

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13
Q

What questions do we ask to ensure a study has validity?

A

Pre study

  • Why this location
  • Why this (sub)population
  • Does the study design make sense

Mid study

  • Why this end point (e.g. DALY over morbidity)
  • Why this sample size
  • Why this duration

Post study

  • Why this method of displaying results
  • Why this stats test
  • Why this conclusion
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14
Q

What are the three qualities we want in our study to make it a good study?

A

Validity, importance and generalisability

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15
Q

Why do we want a generalisable study?

A

Allows us to inform different systems, don’t want to to be too specific for only one location/population etc.

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16
Q

What does the importance of a study tell us?

A

Tells us the playoff between statistically significant data and the effect size- does it only have a very small effect size , is this effect worthwhile?

17
Q

What are the three ethical principles we must abide by?

A
  1. Autonomy/ respect for other persons
  2. Benevolence/ non-maleficence
  3. Justice/ equality among individuals.
18
Q

What did the Nuremberg code emphasise?

A

Voluntary participation

19
Q

What does the declaration of Helsinki emphasise?

A

Looks at risk and benefit and safeguarding participants.

20
Q

What is an impartial witness?

A

Someone who signs on behalf of someone else in areas of illiteracy- they must be IMPARTIAL i.e. not part of study group and not paid. They countersign the participant’s finger print.

21
Q

What is the age of consent and what is the exception to this?

A

18 unless an emancipated minor.

22
Q

What are the 7 ethical requirements?

A
  1. Social and scientific value
  2. Scientific validity
  3. Fair participant selection
  4. Favourable risk-benefit ratio
  5. Independent review
  6. Informed consent
  7. Respect (potential and involved participants)