Reproductive Pathology (Malignant Female)

Question 1

Immature teratoma

typically represented by…

Answer 1

• *Immature, aggressive, mean SOB

* *Typically represented by immature/embryonic-like neural tissue and possibly fetal tissue

Question 2

Granulosa cell tumor
similar to which benign tumor
often produces (2)
common presenting symptoms
causes what in adolescents
the histology give-away

Answer 2

• *Similar to thecoma except granulosa tumors are malignant
• *Often produces ESTROGEN and/or PROGESTERONE
• *ABNORMAL UTERINE BLEEDING
• *Sexual precocity (in adolescents) and breast tenderness
• *CALL-EXNER BODIES

Question 3

Serous cystadenocarinoma
How common?
Location?
Histology give-away

Answer 3

Most common ovarian neoplasm
Frequently bilateral
**PSAMMOMA BODIES

Question 4

Mucinous cystadenocarinoma
similar to what benign neoplasm
What is the difference and feared complication of this neoplasm?

Answer 4

Similar to mucus cystadenoma except this one is malignant and can rupture.
If it ruptures then PSEUDOMYXOMA PERITONEI occurs which is intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor

Question 5

Dysgerminoma
most common in which patient population
histology
tumor markers (2)

Answer 5

Most common is adolescents

• *SHEETS OF UNIFORM “FRIED EGG” CELLS
• *hCG and LDH are tumor markers

Question 6

Choriocarcinoma:
malignancy of what tissue
what is NOT present
Presents with which systemic triad of symptoms?
What comes out of the hoo hoo?
Spread to which organ? how?
Treatment?
What else should you check for?

Answer 6

Malignancy of trophoblastic tissue (cytotrophoblasts, synchytiotrophoblasts)
**NO CHORIONIC VILLI PRESENT
Presents with INCREASED B-hCG (like really high), SOB, and hemoptysis.
Also presents with bloody, brown vaginal discharge
Hematogenous spread to lungs
Very responsive to chemotherapy
Check for moles!!!

Question 7

Yolk sac tumor
common location
appearance
histology give away
tumor marker (1)

Answer 7

Aggressive–> ovaries or testes
Yellow, friable (hemorrhagic), solid mass
**50% have SCHILLER-DUVAL BODIES (resemble glomeruli)
AFP is appropriate tumor marker

Question 8

Krukenberg tumor

Answer 8

GI malignancy that metastasizes to ovaries causing “MUCIN-SECRETING SIGNET CELL ADENOCARINOMA”

Question 9

Squamous cell carcincoma of the vagina

• -Usually secondary to what?
• -Associated with (3) all similiar though

Answer 9

Usually secondary to cervical SCC

Associated with HPV 16, 18, and 31

Question 10

Clear cell adenocarcinoma of the vagina

–caused by exposure to what?

Answer 10

Exposure to DES in utero

DES used from 194-1971

Question 11

Sarcoma botryoides

• age group
• -tumor cell shape and stain
• -gross appearance

Answer 11

Affects girls less than 4yo
Spindle-shaped tumor cells that are DESMIN+
Literally means “bunch of grapes”