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Reproductive/GU Flashcards

1
Q

Drug class for Folic Acid

A

water soluble vitamin

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2
Q

Indications for Folic Acid

A

supplement to prevent neural tube defects

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3
Q

MoA for Folic Acid

A

required for formation of multiple co-enzymes in protein synthesis

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4
Q

Drug class for Pyridoxine + Doxylamine

A

anti-nauseants
Doxylamine=antihistamine
Pyridoxin=Vit B6

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5
Q

Indications for Pyridoxine + Doxylamine

A

N/V in pregnancy

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6
Q

MoA for Pyridoxine + Doxylamine

A

inhibits CRTZ; diminishes vestibular stimulation; depresses labyrinthine function; sedating

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7
Q

Drug class for Methyldopa

A

anti-hypertensive: central alpha adrenergic inhibitor

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8
Q

Indications for Methyldopa

A

HTN in PG

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9
Q

MoA for Methyldopa

A

central alpha-adrenergic inhibition decreasing sympathetic outflow to heart, kidneys, peripheral vasculature

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10
Q

Drug class for Labetalol

A

anti-hypertensive: non-selective alpha1 & beta receptor blocker

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11
Q

Indications for Labetalol

A

HTN in PG

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12
Q

MoA for Labetalol

A

blocks alpha, beta1, beta2 adrenergic receptors

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13
Q

Drug class for Magnesium sulfate

A

tocolytic agent

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14
Q

Indications for Magnesium sulfate

A

premature labor/eclampsia; seizure; torsade de pointes; severe Mg deficiency; unresponsive status asthmaticus (kids)

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15
Q

MoA for Magnesium sulfate

A

decreased AcH in motor nerve terminals; slows rate SA node impulse formation; relaxation of bronchial smooth muscle

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16
Q

Drug class for Loestrin Fe 1/20

A

COC: monophasic

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17
Q

Drug class for Lo Loestrin Fe

A

COC: biphasic

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18
Q

Indications for Loestrin Fe 1/20 & Lo Loestrin Fe

A

contraception

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19
Q

Drug class for Triphasil

A

COC: triphasic

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20
Q

Drug class for Natazia

A

COC: quadriphasic

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21
Q

Indications for Triphasil & Natazia

A

contraception, peri-menopause

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22
Q

MoA for Loestrin Fe 1/20, Lo Loestrin Fe, Triphasil, Natazia

A

suppression of FSH, LH w/ suppression of ovulation, & reduced implantation, thickening cervical mucus, decrease tubal mortality

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23
Q

Drug class for Ovrette

A

Progestin-only OC

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24
Q

Indications for Ovrette

A

contraception; especially in women where COC is contra-indicated

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25
Q

MoA for Ovrette

A

prevent mid-cycle FSH/LH surge, inhibit ovulation, inhibit implantation, thicken cervical mucus, slow tubal transport

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26
Q

Drug class for Lybrel

A

extended cycle OC

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27
Q

Indications for Lybrel & Quartette

A

contraception; women w/ menstrual related sxs (HA, menorrhagia, anemia, endometriosis-pain)

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28
Q

MoA for Lybrel & Quartette

A

prevent mid-cycle FSH/LH surge, inhibit implantation, thicken cervical mucus, slow tubal transport

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29
Q

Drug class for Quartette

A

quadriphasic ascending dose: extended cycle OC

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30
Q

Drug class for Conjugated Equine Estrogen CEE [Premarin]

A

Estrogen

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31
Q

Indications for CEE [Premarin]

A

moderate to severe vasomotor sxs; vaginal mucosal atrophy, hypogonadism

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32
Q

MoA for CEE [Premarin]

A

estrogen supplement

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33
Q

Drug class for MPA [Provera]

A

progesterone

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34
Q

Indications for MPA [Provera]

A

contraception; esp in women who have contra-indications for EE

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35
Q

MoA for MPA [Provera]

A

prevent mid-cycle FSH/LH surge, inhibit ovulation, inhibit implantation, thicken cervical mucus, slow tubal transport

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36
Q

Drug class for Mifepristone

A

abortifactant

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37
Q

Indications for Mifepristone

A

early pregnancy termination

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38
Q

MoA for Mifepristone

A

inhibits progesterone receptors, antagonizing endometrial & myometrial effects

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39
Q

Drug class for Ulipristal

A

post exposure contraception

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40
Q

Indications for Ulipristal

A

emergency contraception

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41
Q

MoA for Ulipristal

A

binds to progesterone receptor, inhibiting or delaying ovulation; alters endometrium possibly preventing implantation

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42
Q

Drug class for Flibanserin

A

mixed 5-HT1A agonist/5-HT2A agonist

43
Q

Indications for Flibanserin

A

acquired generalized hypoactive sexual desire disorder in premenopausal females

44
Q

MoA for Flibanserin

A

not known, although is known to be an agonist at 5-HT1A & antagonist at 5-HT2A receptors: moderate activity at other CNS receptors

45
Q

Drug class for Ospemifene

A

selective estrogen receptor modulator

46
Q

Indications for Ospemifene

A

moderate to severe dyspareunia due to vulvar/vaginal atrophy in postmenopausal females

47
Q

MoA for Ospemifene

A

selective activation/inhibition of estrogen pathways in different tissues; agonistic effects on endometrium

48
Q

Drug class for Metronidazole

A

antibiotic

49
Q

Indications for Metronidazole

A

trichomoniasis, bacterial vaginosis

50
Q

MoA for Metronidazole

A

inhibits protein synthesis in susceptible organisms when chemical structure is reduced

51
Q

Drug class for Ceftriaxone

A

antibiotic

52
Q

Indications for Ceftriaxone

53
Q

MoA for Ceftriaxone

A

in actively growing bacterial cells, interferes w/ transpeptidation of bacterial cell walls by binding to penicillin binding protein

54
Q

Drug class for Azithromycin

A

antibiotic

55
Q

Indications for Azithromycin

A

chlamydia, PID, acute bacterial exacerbations

56
Q

MoA for Azithromycin

A

reversibly binds to 50S subunit of bacterial ribosome & inhibit protein synthesis

57
Q

Drug class for Benthazine Penicillin G

A

antibiotic

58
Q

Indications for Benthazine Penicillin G

59
Q

Drug class for Nitrofurantoin

A

antibiotic

60
Q

Indications for Nitrofurantoin

A

px/tx of UTIs

61
Q

MoA for Nitrofurantoin

A

inhibits several bacterial enzyme systems (acetyl CoA) interfering w/ metabolism & possibly cell wall synthesis

62
Q

Drug class for Doxycycline

A

antibiotic

63
Q

Indications for Doxycycline

64
Q

MoA for Doxycycline

A

interferers w/ bacterial 30S ribosome protein production

65
Q

Drug class for Tenofovir/Emtricitabine

A

anti-retroviral

66
Q

Indications for Tenofovir/Emtricitabine

A

HIV1, HIV prophylaxis

67
Q

MoA for Tenofovir/Emtricitabine

A

each interferes w/ DNA polymerase function resulting in viral inhibition

68
Q

Drug class for Valacyclovir

69
Q

Indications for Valacyclovir

A

mucocutaneous HSV 1 & 2, VZV infections

70
Q

MoA for Valacyclovir

A

inhibits viral DNA synthesis & viral replication

71
Q

Drug class for Clotrimazole cream

A

anti-fungal

72
Q

Indications for Clotrimazole cream

A

candidiasis (vulvovaginal or breast)

73
Q

MoA for Clotrimazole cream

A

alters fungal cell wall permeability & mess up fungi in other ways

74
Q

Drug class for Ibuprofen

75
Q

Indications for Ibuprofen

A

pain secondary to inflammation in selected patients

76
Q

MoA for Ibuprofen

A

inhibits COX1 & COX2 enzymes reducing PG, prostacyclin, thrombaxone

77
Q

Drug class for Finasteride

A

5alpha-reductase inhibitor

78
Q

Indications for Finasteride

A

benign prostatic disease (generally second-line for moderate-severe BPH)

79
Q

MoA for Finasteride

A

decreases prostatic tissue growth secondary to inhibiting conversion of testosterone to dihydrotestosterone

80
Q

Drug class for Tamulosin

A

alpha1 adrenergic antagonist

81
Q

Indications for Tamulosin

A

benign prostatic disease (moderate-severe symptoms)

82
Q

MoA for Tamulosin

A

relax bladder neck, prostatic urethra, prostatic smooth muscle

83
Q

Drug class for Leuprolide

A

anti-androgen

84
Q

Indications for Leuprolide

A

palliative treatment for prostate cancer; endometriosis

85
Q

MoA for Leuprolide

A

GnRH agonist; agonist of LHRH

86
Q

Drug class for Flutamide

A

anti-androgen

87
Q

Indications for Flutamide

A

metastatic prostate cancer w/ LHRH agonist

88
Q

MoA for Flutamide

A

non-steroidal anti-androgen that inhibits androgen binding in target tissues

89
Q

Drug class for Testosterone

A

sex hormone androgen

90
Q

Indications for Testosterone

A

hypogonadism

91
Q

MoA for Testosterone

A

replacement

92
Q

Drug class for Imipramine

A

tricyclic antidepressant

93
Q

Indications for Imipramine

A

depression; off label for anti-cholinergic impact on UI

94
Q

MoA for Imipramine

A

increase synaptic [serotonin, NE]; down regulation of beta-adrenergic receptors; anti-cholinergic effect

95
Q

Drug class for Tolterodine & Oxybutinin

A

M3 antimuscarininc

96
Q

Indications for Tolterodine & Oxybutinin

A

overactive bladder, urge incontinence

97
Q

MoA for Tolterodine & Oxybutinin

A

selective antagonists of bladder muscarinic receptors decrease detrusor muscle pressure, increase residual urine volume

98
Q

Drug class for Sildenafil & Tadalafil

A

PDE5 inhibitor

99
Q

Indications for Sildenafil & Tadalafil

A

erectile dysfunction; pulm artery hypertension

100
Q

MoA for Sildenafil & Tadalafil

A

inhibits PDE5 to increase [NO] leading to corpus cavernous relaxation & inflow of blood to cause erection

101
Q

Drug class for Mirabegron

A

beta3 agonist

102
Q

Indications for Mirabegron

A

overactive bladder w/ sxs of urinary frequency, urgency, or urge incontinence

103
Q

MoA for Mirabegron

A

activates beta-3 adrenergic receptors in bladder relaxing detrusor muscle during urine storage phase

Pharmacology (16 decks)

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