Anti-neoplastics

Question 1

Drug class for Cyclophosphimide

Answer 1

Alkylating agents

Question 2

MoA for Cyclophosphimide

Answer 2

DNA cross linker (inhibits DNA synthesis & cell division)

Question 3

Indications for Cyclophosphimide

Answer 3

leukemia, lymphoma, nephrotic syndrome, multiple immune mediated diseases

Question 4

Drug class for Carbumustine

Answer 4

Alkylating agents: nitroureas

Question 5

MoA for Carbumustine

Answer 5

DNA cross linker (inhibits DNA synthesis & cell division)

Question 6

Indications for Carbumustine

Answer 6

brain tumors, multiple myeloma, lymphoma

Question 7

Drug class for Cisplatin

Answer 7

Platinum analogs

Question 8

MoA for Cisplatin

Answer 8

DNA cross linker triggering apoptosis

Question 9

Indications for Cisplatin

Answer 9

small cell lung cancer, ovarian cancer, lymphoma, germ cell tumors

Question 10

Drug class for Methotrexate

Answer 10

Antimetabolites: antifolate

Question 11

MoA for Methotrexate

Answer 11

inhibits dihydrofolate reductase & DNA production, inhibits production of cytokines

Question 12

Indications for Methotrexate

Answer 12

recent RA (less than 6 months), low disease activity, no poor prognostic features, cancer remission

Question 13

Drug class for 5flurouracil

Answer 13

Antimetabolites: fluropyrimidines

Question 14

MoA for 5flurouracil

Answer 14

• suicide inhibitor through inhibition of thymidylate synthase
• F-UMP pump interferes w/ RNA/DNA synthesis by replacing nucelic acid bases

Question 15

Indications for 5flurouracil

Answer 15

anal, breast, colorectal, stomach, pancrease, head & neck cancers

Question 16

Drug class for Cytarabine

Answer 16

Antimetabolite: deoxycitidine analogs

Question 17

MoA for Cytarabine

Answer 17

intereferes with DNA and RNA polymerase synthesis

Question 18

Indications for Cytarabine

Answer 18

AML, non-Hodgkin lymphoma

Question 19

Drug class for 6MTP

Answer 19

Antimetabolites: purine antagonists

Question 20

MoA for 6MTP

Answer 20

• competes with hypoxanthine & guanine for the enzyme HGPRTase & is convereted to thioinosinic acid
• inhibits DNA synthesis

Question 21

Indications for 6MTP

Answer 21

leukemia, Non-Hodgkins, psoriatic arthritis, polycythemia vera, Crohn’s

Question 22

Drug class for Vincristine

Answer 22

Vinka alkaloids

Question 23

MoA for Vincristine

Answer 23

binds to tubulin dimers, inhibiting assembly of microtubule structures & arresting mitosis in metaphase (inhibiting DNA synthesis)

Question 24

Indications for Vincristine

Answer 24

non-Hodgkins, ALL

Question 25

Drug class for Paclitaxel

Answer 25

-Taxanes

Question 26

MoA for Paclitaxel

Answer 26

-Inhibiting assembly of microtubule structures, arresting chromosome segregation & cell division

–inhibits DNA synthesis by inhibiting formation of the mitotic spindle in the “M” phase

Question 27

Indications for Paclitaxel

Answer 27

-ovarian, breast, lung, bladder, prostate, melanoma, esophageal, Kaposi’s sarcoma

*not leukemias & lymphomas

Question 28

Drug class for Doxorubicine

Answer 28

Antitumor antibiotics

Question 29

MoA for Doxorubicin

Answer 29

• interacts w/ DNA binding macromolecular biosynthesis
• inhibits topoisomerase II
• unclear bu inhibits DNA synthesis

Question 30

Indications for Doxorubicin

Answer 30

leukemia, Hodgkin’s, bladder, breast, stomach, lung, ovaries, thyroid, sarcoma, multiple myeloma

Question 31

Drug class for Cetuximab

Answer 31

Misc GFR inhibitors

Question 32

MoA for Cetuximab

Answer 32

monoclonal mouse-human IgE antibody

Question 33

Indications for Cetuximab

Answer 33

colorectal metastatic (& head & neck)

Question 34

Drug class for Pegaspargase

Answer 34

Misc GFR inhibitors

Question 35

Indications for Pegaspargase

Answer 35

only used in ALL if patient has allergy to first line drug