Reproductive and Hormonal Function of the Male Flashcards
The three major subdivisions of the male reproductive functions
- Spermatogenesis, which means the formation of sperm
- Performance of the male sexual act
- Regulation of male reproductive functions by the various hormones.
Physiological Anatomy of the Male
Sexual Organs
The testis is composed of up to 900 coiled seminiferous tubules, each averaging more than one-half meter long, in which the sperm are formed.
The sperm then empty into the epididymis, which is another coiled tube about 6 meters long.
The epididymis leads into the vas deferens, which enlarges into the ampulla of the vas deferens immediately before the vas enters the body of the
prostate gland.
Two seminal vesicles, empty into the prostatic end of the ampulla, and the contents pass into an ejaculatory duct leading through the body of the
prostate gland and then emptying into the internal urethra.
Prostatic ducts (part of the ejaculatory duct that runs through the prostate gland)also empty from the prostate gland into the ejaculatory duct and from there into the prostatic urethra.
The urethra is the last connecting link from the testis to the exterior. The urethra receives mucus derived from a large number of minute urethral
glands located along its entire extent and even more so from bilateral bulbourethral glands (Cowper glands) located near the origin of the urethra.
When does Spermatogenesis occur
During embryonic development, the primordial germ cells migrate into the
testes and become immature germ cells
called spermatogonia, which lie in two or
three layers of the inner surfaces of the
seminiferous tubules.
At puberty the spermatogonia begin to undergo mitotic division and continually proliferate and differentiate through definite stages of development to form sperm.
Stages in
the development of sperm from spermatogonia
Steps in Spermatogenesis
Spermatogenesis occurs in the seminiferous tubules during active sexual life as the result of stimulation by anterior pituitary gonadotropic hormones.
Spermatogenesis begins at an average age of 13 years (puberty) and continues throughout most of the remainder of life but decreases markedly in
old age.
In the first stage of spermatogenesis, the spermatogonia migrate among
Sertoli cells toward the central lumen of the seminiferous tubule
Spermatogonia that cross the barrier into the Sertoli cell layer become
progressively modified and enlarged to form large primary spermatocytes
These primary spermatocytes, in turn, undergoes meiotic division to form two secondary spermatocytes. After another few days, these secondary
spermatocytes also divide to form spermatids that are eventually modified to
become spermatozoa (sperm).
Meiosis
During the change from the spermatocyte stage to the spermatid stage, the 46 chromosomes (23 pairs of chromosomes) of the spermatocyte are divided, and thus 23 chromosomes go to one spermatid and the other 23 go to the second spermatid.
The entire period of spermatogenesis,
from spermatogonia to spermatozoa,
takes about 74 days.
Sex Chromosome
In each spermatogonium, one of the 23 pairs of chromosomes carries the genetic information that determines the sex of each eventual offspring.
This pair (XY) is composed of one X chromosome, which is called the female chromosome, and one Y chromosome, the male chromosome.
During meiotic division, the male Y chromosome goes to one spermatid that then becomes a male sperm, and the female X chromosome goes to
another spermatid that becomes a female sperm.
The sex of the eventual
offspring is determined by which of these two types of sperm fertilizes the
ovum.
Sperm structure
Each spermatozoon is composed of a head and a tail.
The head comprises the condensed nucleus of the cell, with only a thin cytoplasmic and cell membrane layer around its surface.
On the outside of the anterior two thirds of the head is a thick cap called
the acrosome that is formed mainly from the Golgi apparatus.
The acrosome contains several enzymes similar to those found in lysosomes
of the typical cell, including hyaluronidase (which can digest proteoglycan
filaments of tissues) and powerful proteolytic enzymes (which can digest
proteins).
These enzymes play important roles in allowing the sperm to enter the ovum
and fertilize it.
Structure of the human spermatozoon.
The tail of the sperm, called the
flagellum, has three major components:
- A central skeleton constructed
of 11 microtubules, collectively
called the axoneme. - A thin cell membrane covering
the axoneme; and - A collection of mitochondria surrounding the axoneme in the proximal portion of the tail (called
the body of the tail ).
Back-and-forth movement of the tail provides motility for the sperm.
The energy for this process is supplied in the form of ATP, which is synthesized by the mitochondria in
the body of the tail.
Hormonal Factors That Stimulate
Spermatogenesis
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
Estrogen
Growth Hormone
Testosterone
Secreted by the Leydig cells located in the interstitium of the testis, is essential for growth and division of the testicular germinal cells, which is the first stage in forming sperm.
Luteinizing Hormone
Secreted by the anterior pituitary gland, stimulates the Leydig cells to secrete testosterone
Follicle-Stimulating Hormone
Also secreted by the anterior pituitary gland,stimulates the Sertoli cells, without this stimulation, the conversion of spermatids to sperms(Process of spermatogenesis) will not occur
Estrogen
Formed from testosterone by the Sertoli cells when they are
stimulated by follicle-stimulating hormone, are probably also essential for
spermiogenesis.
Growth hormone
Specifically promotes early division of the spermatogonia
themselves; in its absence spermatogenesis is severely deficient or absent,
thus causing infertility.
Storage of Sperm in the Epididymis
After formation in the seminiferous tubules, the sperm require several days to pass through the 6-meter-long tubule of the epididymis.
Sperm removed from the seminiferous tubules and from the early portions
of the epididymis are non-motile and cannot fertilize an ovum.
However, after the sperm have been in the epididymis for 18 to 24 hours, they develop the capability of motility, even though several inhibitory
proteins in the epididymal fluid still prevent final motility until after ejaculation.
They can remain stored in the epididymis, for at least a month. During this time, they are kept in a deeply suppressed, inactive state.
However, with a high level of sexual activity and ejaculations, they may be stored no longer than a few days.
Function of the Seminal Vesicles
Each seminal vesicle secretes a mucoid material containing an abundance
of fructose, citric acid, and other nutrient substances, as well as large
quantities of prostaglandins and fibrinogen. Prostaglandins are believed to aid fertilization in two ways:
(1) reacting with the female cervical mucus to make it more receptive to sperm
movement and
(2) by possibly causing backward, reverse peristaltic contractions in the uterus
and fallopian tubes to move the ejaculated sperm toward the ovaries (a few
sperm reach the upper ends of the fallopian tubes within 5 minutes).
During the process of emission and ejaculation, each seminal vesicle empties
its contents into the ejaculatory duct shortly after the vas deferens empties
the sperm.
This action adds greatly to the bulk of the ejaculated semen, and the fructose
and other substances in the seminal fluid are of considerable nutrient value
for the ejaculated sperm until one of the sperm fertilizes the ovum.
Life span of ejaculated sperm
The normal motile, fertile sperm are capable of flagellated movement through the fluid medium at velocities of 1 to 4 mm/min.
The activity of sperm is greatly enhanced in a neutral and slightly alkaline medium, as exists in the ejaculated semen, but it is greatly depressed in a
mildly acidic medium.
A strong acidic medium can cause the rapid death of sperm.
The activity of sperm increases markedly with increasing temperature, but
so does the rate of metabolism, causing the life of the sperm to be considerably shortened.
Although sperm can live for many weeks in the suppressed state in the genital ducts of the testes, the life expectancy of ejaculated sperm in the
female genital tract is only 1 to 2 days.
Function of the Seminal Vesicles
Each seminal vesicle secretes a mucoid material containing an abundance of fructose, citric acid, and other nutrient substances, as well as large
quantities of prostaglandins and fibrinogen.
Prostaglandins are believed to aid fertilization in two ways:
- Reacting with the female cervical mucus to make it more receptive to sperm movement and
- Possibly causing backward, reverse peristaltic contractions in the uterus and fallopian tubes to move the ejaculated sperm toward the ovaries (a few
sperm reach the upper ends of the fallopian tubes within 5 minutes).
During the process of emission and ejaculation, each seminal vesicle empties its contents into the ejaculatory duct shortly after the vas deferens empties
the sperm.
This action adds greatly to the bulk of the ejaculated semen, and the fructose and other substances in the seminal fluid are of considerable nutrient value
for the ejaculated sperm until one of the sperm fertilizes the ovum.
Function of the Prostate Gland
The prostate gland secretes a thin, milky fluid that contains calcium, citrate ion, phosphate ion, a clotting enzyme, and a profibrinolysin.
The slightly alkaline characteristic of the prostatic fluid may be quite important for successful fertilization of the ovum because the fluid of the vas
deferens is relatively acidic due to citric acid and metabolic end products of the sperm, inhibiting sperm fertility.
Also, the vaginal secretions of the female are acidic (with a pH of 3.5 to 4.0). Sperm do not become optimally motile until the pH of the surrounding
fluids rises to about 6.0 to 6.5.
Consequently, it is probable that the slightly alkaline prostatic fluid helps neutralize the acidity of the other seminal fluids during ejaculation and thus
enhances the motility and fertility of the sperm.
Semen
Semen, is composed of the fluid and sperm from the vas deferens (about 10 percent of the total), fluid from the seminal vesicles (almost 60 percent), fluid from the prostate gland (about 30 percent), and small amounts from the mucous glands, especially the
bulbourethral glands.
The bulk of the semen is seminal vesicle fluid, which is the last to be ejaculated and
serves to wash the sperm through the ejaculatory duct and urethra.
The average pH of the combined semen is about 7.5, with the alkaline prostatic fluid
having more than neutralized the mild acidity of the other portions of the semen.
The prostatic fluid gives the semen a milky appearance, and fluid from the seminal
vesicles and mucous glands gives the semen a mucoid consistency.
Also, a clotting enzyme from the prostatic fluid causes the fibrinogen of the seminal vesicle fluid to form a weak fibrin coagulum that holds the semen in the deeper regions of the vagina where the uterine cervix lies.
In the early minutes after ejaculation, the sperm remain relatively immobile, possibly because of the viscosity of the coagulum. As the coagulum dissolves, the sperm
simultaneously become highly motile.
Once sperm are ejaculated in the semen, their maximal life span is only 24 to 48 hours at body temperature.
At lowered temperatures, however, semen can be stored for several weeks, and when frozen at temperatures below −100°C, sperm have been preserved for years.
“Capacitation” of Spermatozoa Is Required
for Fertilization of the Ovum
Although spermatozoa are said to be “mature” when they leave the epididymis, their activity is held in check by multiple inhibitory factors
secreted by the genital duct epithelia.
Therefore, when they are first expelled in the semen, they are unable to fertilize the ovum.
However, on coming in contact with the fluids of the female genital tract, multiple changes occur that activate the sperm for the final processes of
fertilization.
These collective changes are called capacitation of the spermatozoa, which normally requires from 1 to 10 hours.
“Capacitation” of Spermatozoa:
The changes which are associated with Capacitation
- The uterine and fallopian tube fluids removes the various inhibitory factors that suppress sperm activity in the male genital ducts.
- While the spermatozoa remain in the male genital ducts, they are continually exposed to large amounts of cholesterol. This cholesterol toughens the membrane of the acrosome preventing release of its
enzymes. However, after ejaculation, the sperm lose much of their cholesterol causing the membrane at the acrosome becomes much weaker. - The membrane of the sperm becomes much more permeable to calcium ions, so calcium now enters the sperm and changes the activity of the flagellum, giving it a powerful whiplash motion in contrast to its previously weak undulating motion. In addition, calcium makes it possible for the acrosome to release its enzymes rapidly as the sperm penetrates the
granulosa cell mass surrounding the ovum.
Thus, multiple changes occur during the process of capacitation. Without these changes, the sperm cannot make its way to the interior of the ovum
to cause fertilization.
Acrosome Enzyme and Penetration of the
Ovum
Stored in the acrosome of the sperm are large quantities of hyaluronidase and proteolytic enzymes.
Hyaluronidase acts on the hyaluronic acid polymers in the intercellular cement that holds the ovarian granulosa cells together.
The proteolytic enzymes digest proteins in the structural elements of tissue cells that still adhere to the ovum.
Before a sperm can fertilize an ovum, it must dissolute the granulosa cell layers, and then it must penetrate through the thick covering of the ovum itself, the zona pellucida.
The sperm binds with receptor proteins in the zona pellucida.
The entire acrosome rapidly dissolves, releasing it’s enzymes. It is believed that the hyaluronidase among these enzymes is especially important in opening
pathways between the granulosa cells so that the sperm can reach the ovum.
Within another 30 minutes, the cell membranes of the sperm head and of the oocyte fuse with each other to form a single cell. At the same time, the genetic material of the sperm and the oocyte combine to form a completely new cell genome, containing equal numbers of chromosomes and genes
from mother and father.
This is the process of fertilization; the embryo then
begins to develop
Male Sexual Act: Neuronal Stimulus for
Performance of the Male Sexual Act
The most important source of sensory nerve signals for initiating the male sexual act is the glans penis.
The glans contains an especially sensitive sensory end-organ system that transmits into the central nervous system of sensation called sexual
sensation.
The slippery massaging action of intercourse on the glans stimulates the sensory end organs, and the sexual signals in turn pass through the
pudendal nerve, then through the sacral plexus into the sacral portion of the spinal cord, and finally up the cord to undefined areas of the brain.
Areas adjacent to the penis may aid in stimulating the sexual act.
Stimulation of the anal epithelium, the scrotum, and perineal structures in general can send signals into the cord that add to the sexual sensation