Reproduction Male and Female anatomy Flashcards
Name the 3 stages of sexual differentiation. Each stage is dependent on the previous.
- Chromosomal: XX (female), XY (male)
- Gonadal: Testis, Ovaries
- Phenotype: Male, Female
What role does sperm play in Chromosomal Sex Differentiation?
Sperm contributes either X or Y to determine sex at FERTILIZATION
What is the undifferentiated precursor of the gonad?
Gonadal (Genital) Ridge
What is the gonadal (genital) ridge located next to?
Mesonephros
What is the precursor for oocytes and spermatazoa?
Gametes
What do gametes develop from?
Primordial Germ Cells (PGCs)
Where do PGCs originate? Where do they travel?
Develop in Yolk Sac and migrate to Gonadal Ridge to become Primitive Sex Chords
Embryology process
Primordial Germ Cells -> Primitive Sex Chord -> Gametes -> Oocyst or spermatazoa
When does embryo become fetus?
After Organogenesis
What does SRY stand for and what is it associated with?
Sex determining region of the Y chromosome. Involved in gonadal (testis) differentiation.
What does SRY gene code for?
SRY protein/ Testis determining factor
What is involved in Testis Determination?
SRY gene
Is ovarian determination default?
No, requires some genes on X chromosome to be present. Needs more than just the absence of the SRY gene on the Y chromosome.
First cells to develop from epithelium of gonadal ridge? Second cells?
Sertoli Cells
Ledig Cells
What do the sex chords develop into?
Seminiferous Tubules
What hormone do Sertoli cells produce? What effect does this hormone have?
Anti-Mullerian Hormone: develop Leydig cells
What do Leydig cells produce?
Testosterone
Role of Sex Chords in Ovarian development?
Regress
2 Hormone producing cells in female?
Theca and Granulosa Cells
Name the two ducts sytems in Sexual Development
- Mesonephric Duct (Wolfian duct)
2. Paramesonephric Duct (Mullerian duct)
Testosterone produce from Leydig cells develops what duct system?
- Mesonephric Duct (Wolfian Duct)
Sertoli Cells produce Ani-Mullerian Hormone which regresses which duct system?
Paramesonephric Duct (Mullerian Duct)
3 Specific structures that develop from the Mesonephric/Wolfian duct?
- Epididymus
- Urethra
- Deferent Ducts
4 Specific structures that develop from the Paramesonephric/mullerian duct?
- Oviducts
- Uterus
- Cervix
- Cranial Vagina
2 hormones produced by testes responsible for phenotypic sex?
- Dihydrotestosterone (DHT), main player
2. Testosterone
Genital Tubercle becomes what in presence of DHT? Absence?
Penis
Clitoris
Genital Swelling becomes what in presence of DHT? Absence?
Scrotum
Vulva