Repro Quiz Flashcards
How does flutamide differ from finasteride in relation to MOA and clinical use?
Flutamide inhibits androgen by blocking the testosterone receptor whereas finasteride is a 5 alpha reductase inhibitor. Flutamide treats prostatic adenocarcinoma and finasteride treats BPH and male pattern baldness
What is the clinical use of clomiphene? How does this drug work?
For infertility treatment. SERM- selective estrogen receptor modulator. Agonist at pituitary estrogen receptors, inducing FSH secretion.
Most common breast mass in postmenopausal women
Invasive ductal carcinoma
Most common form of breast cancer
Invasive ductal carcinoma
Small, mobile, firm breast mass with sharp edges in a 24 year old woman
Fibroadenoma
Multiple bilateral fluid-filled lesions with diffuse breast pain
Fibrocystic breast changes
Firm fibrous mass in a 55 yr old women
Invasive ductal carcinoma
What are the side effects of sidenafil?
Flushing, headache, dyspepsia, impaired blue green color vision, life threatening hypotension when take w/ nitrates
What is the role of Sertoli cells and Leydig cells in male spermatogenesis?
Sertoli cells make androgen binding protein (ABP) and inhibin (inhibits FSH), support spermatogenesis by providing nutrition to developing spermatocytes. Sertoli cells are stimulated by FSH.
Leydig cells make testosterone when stimulated by LH.
What is the difference between androgen insensitivity and 5-alpha reductase deficiency?
Androgen insensitivity is testicular feminization where you have a defect in the DHT receptor where it does not respond to DHT. These are PHENOTYPICALLY normal females, but have testes -> will see elevation of testosterone, estrogen and LH in these individuals.
5 alpha reductase deficiency -> you cannot generate DHT so the early defect is ambiguous genitalia until puberty, when testosterone will mature it into normal male genitalia. These patients have normal testosterone, normal estrogen and LH.
What is the most common cause of DIC?
STOP Making New Thrombi Sepsis Trauma Obstetric complications Pancreatitis Malignancy Nephrotic syndrome Transfusion
What is the most common heart murmur
Mitral valve prolapse
What is the most common coronary artery involved in thrombosis
left anterior descending (LAD)
What is the most common cause of death in lupus patients
Lupus nephropathy, lupus renal disease
What is the most common congenital heart anomaly?
VSD
