Male anatomy, physiology, and pathology

Question 1

**Which cells are responsible for maintaining a high testosterone concentration in the seminiferous tubules?

Answer 1

Sertoli cells. Leydig cells produce the testosterone but it is the androgen binding protein that maintains the high concentration and this comes from the sertoli cells.

Question 2

Testicular tumor composed of cytotrophoblasts and syncytiotrophoblasts

Answer 2

Choriocarcinoma

Question 3

Testicular tumor that may present initially with gynecomastia

Answer 3

Leydig cell tumor > Sertoli cell tumor

Question 4

Testicular tumor with elevated AFP

Answer 4

Yolk sac tumor (endodermal sinus tumor) > embryonal carcinoma

Question 5

Testicular tumor with elevated hCG

Answer 5

Choriocarcinoma > embryonal carcinoma

Question 6

Most common testicular tumor

Answer 6

Seminoma

Question 7

Most common testicular tumor in infants and children up to three years old

Answer 7

Yolk sac tumor (endodermal sinus tumor)

Question 8

Most common testicular tumor in men over 60

Answer 8

Lymphoma (metastatic, often bilateral)

Question 9

Testicular tumor w/ histological appearance similar to koilocytes (cytoplasmic clearing)

Answer 9

Seminoma

Question 10

Testicular tumor that have alveolar or tubular appearance sometimes with papillary convolutions

Answer 10

Embryonal carcinoma

Question 11

Testicular tumor composed of multiple tissues

Answer 11

Teratoma

Question 12

Testicular tumor with histologic endodermal sinus structures (Schiller-Duval bodies)

Answer 12

Yolk sac tumor (endodermal sinus tumor)

Question 13

Testicular tumor: 25% have cytoplasmic rod shaped crystalloids of Reinke

Answer 13

Leydig cell tumor

Question 14

Testicular tumor that is androgen producing and a/w percocious puberty

Answer 14

Leydig cell tumor > sertoli cell tumor

Question 15

A 55 year old man undergoing treatment for BPH has increased testosterone and decreased DHT as well as gynecomastia and edema. What is his medication?

Answer 15

Finasteride