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repro drugs 1 Flashcards

1
Q

letrozole

A

aromatase inhibitor - Hormone + breast cancer

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2
Q

anastrozole

A

aromatase inhibitor - Hormone + breast cancer

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3
Q

exemestane

A

aromatase inhibitor - Hormone + breast cancer

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4
Q

norethindrone

A

synthetic progestin –> use in depo contraception

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5
Q

estradiol cypionate

A

estrogen used for ERT b/c longer duration than unmodified E2

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6
Q

raloxifene

A

“SERM that blocks E2 signaling in breast & uterus- used for hormone sensitive cancer
agonist in bone and CV system”

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7
Q

mifepristone/RU486

A

“blocks progesterone activity by recruiting co-repressor

type II antagonist”

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8
Q

ethinyl estradiol

A

estrogen used for hypogonadism and contraception

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9
Q

mestranol

A

estrogen used for hypogonadism and contraception

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10
Q

finasteride

A

inhibits 5-alpha reductase - targets type II - so targets prostate enlargement & male-pattern baldness

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11
Q

flutamide

A

anti-androgen drug for prostate cancer - messes with ARA70

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12
Q

nilutamide

A

anti-androgen drug for prostate cancer

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13
Q

cyproterone acetate

A

anti-androgen drug for prostate cancer

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14
Q

clomiphene

A

used for infertility in PCOS

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15
Q

olaparib

A

PARP inhibitors - for tx of breast cancer with BRCA1/2

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16
Q

carboplatin + paclitaxel

A

chemo of choice for ovarian cancer

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17
Q

BEP - bleomycin, etoposide, cisplatin

A

chemo regiment for germ cell tumors (women)

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18
Q

alprostadil

A

“erectile dysfunction drug
PGE1 analogue
intracavernosal injection or intrameatal application”

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19
Q

PDE 5 inhibitors

A

“erectile dysfunction drugs
inhibit cGMP phosphodiesterase isozyme 5 –> maintains vasodilation
work quickly - peak plasma in 30 - 90 minutes
metabolized by CYP3A4 to an active metaboliste”

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20
Q

pentoxyphylline

A

“used to activate epidydimal and testicular sperm for ICSI

for pts with no sperm in ejaculate”

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21
Q

tx of PCOS

A

“oral contraceptive pills/cyclic progesterone
anti-androgens
weight loss
insulin sensitizing agents”

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22
Q

MMP-9

A

enzyme critical for implantation

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23
Q

diazoxide

A

drug used for hyperinsulinimia –> works on K ATP channel

24
Q

somatostatin

A

“drug for hyperinsulinimia –> blocks Ca+ influx the leads to insulin release
used for somatatrop adenoma (GH)”

25
Q

dopamine agonist

A

“used for somatotroph adenomas
paradozical effect - stimulates production in normal cells but inhibits GH release in adenoma cells
cabergoline”

26
Q

somatostatin analogs

A

“bind to somatostatin receptors on somatotroph cells & inhibits GH release

treats thyrotroph adenomas - reduce secretion of TSH & size of adenoma

octreotid & lanreotide”

27
Q

GH receptor antagonist

A

“bind to growth hormone receptors and prevent GH from binding –> precents dimerization

pegvisomant
most effective current drug for normalization of IGF-1 levels”

28
Q

dopamine agonist

A

“used for lactotroph adenoma & hypercortisolism

cabergoline & bromocriptine”

29
Q

leuprolide

A

“GnRh agonist at pituitary

used in prostate cancer”

30
Q

pasireotide

A

somatostatin analog - inhibits ACTH secretion for hypercortisolemia

31
Q

cabergoline

A

dopamine agonist used to inhibit ACTH secretion for hypercortisolism

32
Q

eplerenone

A

txs primary hyperaldosteronism & K+ sparing volume depltion/ diuretic

33
Q

amiloride

A

“tx for hyperaldosteronism

inhibits ENaC”

34
Q

spirinolactone

A

“K+ sparing diuretic (CHF, essential HTN, cirrhosis, nephrosis ), primary hyperaldosteronism, PCOS/hirtuism
more side effects b/c less specific - gynecomastia, descrease libido, impotence - also binds androgen & progestrone receptors”

35
Q

metyrapone

A

“tx for hyperaldosteronism - inhibits steriodogenesis

inhibits 11 beta hydroxylase”

36
Q

mitotane

A

tx for hypercortisolism - cytotoxic to adrenal cells

37
Q

mifepristone

A

tx hypercortisolism by blocking glucocorticoid receptor

38
Q

eplerenone

A

“decreases action of mineralocorticoids –> prevents binding of aldosterone to mineralocorticoid receptor –>
reducred upregulation of Enac, K+ channel & sodium/potassium pump”

39
Q

PTU

A

“antithyroid med- used after methimazole - more side effects
dosed 3x daily
starting does 100 mg

USE methimazole in all Grave’s pt except:
first trimester pregnancy
thyroid storm
adverse rxn to methimazole”

40
Q

methimazole

A

“antithryroid med - inhibits synthesis of t4/t3
fewer drug induces lupus, vasculitis, hepatitis
starting does 10 - 30 mg”

41
Q

progestin therapy

A

“replacement therapy
contraception & IVF
endometriosis
dysfunctional uterine bleeding”

42
Q

lupron

A

“acts as an agonist at pituitary GnRH receptors.

Used to delay precocious puberty”

43
Q

goserelin

A

LH-RH agonist - used for prostate cancer

44
Q

tx of BRCA-1 cancers

A

“increased sensitivity to cisplatin
reduced sensitivity to taxanes
ParP inhibitors”

45
Q

octeotride

A

“somatotroph analogue used to reduce GH secretion in somatrotroph adenoma

used to inhibit insulin release in insulinoma or hyperinsulin secretion
acts on KatP channel and affects translocation of Ca –> directly inhibits insulin secretion
(SE of this use are suppression of GH, TSH, ACT)”

46
Q

somatostatin actions

A

“ibhibits GH release in pituitary
inhibits TSH, PRL in pituitary
glucagon & insulin in pancreas”

47
Q

what drugs cause primary adrenal insufficiency

A

aminoglutethimide, ketoconazole, etomidate, rifampin, phenytoin

48
Q

ketoconazole

A

“inhibits enzymes in steroidogenesis pathway
used in hypercortisolism
need to check liver fx”

49
Q

amiodarone

A

“used to tx arrhymthemias - 37% iodine

can cause hyper or hypo thyroidism”

50
Q

bisphosphonates

A

“osteoporosis drug that inhibits osteoclast activity & promotes osteoclast death
first line”

51
Q

denosumab

A

osteoporosis drug that inhibits osteoclast activity & inhibits RANKL

52
Q

teriparatide

A

“anabolic agent - increase osteoblast activity
can only use for two years –> will lead to bone absorption
avoid in states of high turnover”

53
Q

calcitonin

A

“osteoporosis drug that inhibits osteoclast activity

third line - only use for acture fracture and pain”

54
Q

serm

A

osteoporosis drug that inhibits osteoclast activity - ER agonist on bone - anti-resorptive

55
Q

estrogen

A

osteoporosis drug that inhibits osteoclast activity

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