Repro Flashcards

1
Q

Indications for Induction

A

Diabetes
Post dates – Term + 7 days
Maternal health problem that necessitates planning of delivery e.g. on treatment for DVT
Fetal reasons e.g. growth concerns, oligohydramnios
Social / maternal request / pelvic pain / “big” babies

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2
Q

Bishop’s score

A

Indicates cervical progressive change and whether
induction is likely to be successful

Dilatation
Length of Cervix - Effacement
Position
Consistency
Station
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3
Q

Induction

A

instigate labour artificially (vaginal birth)

If cervix not dilated and effaced (low Bishop’s score), then vaginal prostaglandin pessaries / Cook Balloon can be used to ripen (open) the cervix - stimulate contraction

Once cervix has dilated and effaced, an amniotomy can be performed — ‘Bishop score’ => 7 amniotomy

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4
Q

Amniotomy

A

Amniotomy is the artificial rupture of the fetal membranes (“waters”) using amniohook

IV oxytocin can be used to achieve adequate contractions – aim for 4-5 contractions in 10 minutes

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5
Q

Active 1st stage of labour

Suboptimal progress is defined as cervical dilatation

A
abdominal and vaginal exam:
Cervical effacement (stretches and gets thinner)
Cervical dilatation (opens)
Descent of the fetal head 

less than 0.5cm per hour for primigravid women
less than 1cm per hour for parous women (having produced offspring)

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6
Q

Inadequate Pregnancy progress

A

Cephalopelvic disproportion (CPD)

  • fetal head too large to negotiate the maternal pelvis
  • caput and moulding develop

Malposition

  • fetal head in an incorrect position for labour
  • ‘relative’ CPD occurs
  • Occipito-posterior & Occipito-transverse

Malpresentation

  • Longitudinal lie Vertex/Breech
  • Transverse lie shoulder
  • Oblique

Inadequate uterine activity
Birth canal obstruction (e.g. ovarian cyst or fibroid)
Fetal Distress
Woman conditions where labour would not be safe
Previous labour complications eg. uterine rupture

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7
Q

Fetal well being in labour is determined by

A

Intermittent auscultation of the fetal heart
Cardiotocography
Fetal blood sampling – when abnormal CTG
–pH and base excess
Fetal ECG

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8
Q

Uterine Hyper-stimulation can result in

A

fetal distress due to insufficient placental blood flow.

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9
Q

Postnatal Problems

Postpartum Haemorrhage

A

Primary = blood loss of >500ml within 24 hrs of delivery
Tone, Trauma, Tissue, Thrombin (4 T’s)

Secondary = > 500ml from 24hrs - 6weeks post partum
Retained tissue, Endometritis (infection), Tears / trauma

NB: Lochia = normal discharge from the uterus after childbirth (3-4 weeks postnatal - “like a period/less”)

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10
Q

Thromboembolic disease in pregnancy / postnatally

High quality risk assessment

A

Pregnancy and the immediate post partum period is a hypercoagulable state

Pregnant women 6-10 times more likely to develop thromboembolism (DVT or PE - tachycardia**)

Suspicious = women with unilateral leg swelling and/or pain and women complaining of SOB or chest pain

Immobilisation following spinal anaesthetic / caesarean section will further increase risk, D-dimer unreliable

Investigate (ECG, Leg Dopplers, CXR +/- VQ scan/CTPA
(NB:radiation exposure during pregnancy/Breastfeed)

Treat with low molecular weight heparin
WARFARIN IS TERATOGENIC, CAN use in Breastfeed

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11
Q

Sepsis = leading cause of maternal death in UK

A

May present atypically

In any woman you suspect sepsis – prompt IV antibiotic administration

Perform full septic screen – blood cultures, LVS, MSSU, wound swabs

Antipyretic measures, IV fluids + referral to hospital if you concerned for pregnant / postnatal woman

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12
Q

Postnatal Depression

A

Can continue on from baby blues or start sometime later
Has classical ‘depressive’ symptoms
Affects functioning, bonding and often requires treatment
Increased risk in women with personal or family history of affective disorde

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13
Q

Puerperal psychosis

A

Rare but serious psychotic illness of the postnatal period
Women can be a danger to themselves and their babies
Requires inpatient psychiatric care
Much more common in women with personal or family history of affective disorder, bipolar disorder or psychosis

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14
Q

ThePearl Index

A
# contraceptive failures per 100 women-years exposure 
looks at the total months or cycles of exposure from the initiation of the product to the end of the study
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15
Q

Life Table Analysis

A

Provides the contraceptive failure rate over a specified time-frame and can provide a cumulative failure rate for any specific length of exposure

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16
Q

Combined Oral Contraceptive Pill

non-contraception functions

A

Regular bleed with a potential reduction in painful heavy menstruation and anaemia

Reduction in functional ovarian cysts

50% reduction in ovarian and endometrial cancer

Improvement in acne

Reduction in benign breast disease, rheumatoid arthritis, colon cancer and osteoporosis

17
Q

Combined Oral Contraceptive Pill Risks

A

Safe for most women, Communicating risk
Serious health risks and ‘nuisance’ side effects

x3 Risk of venous thromboembolism

Ischaemic stroke increased in those with focal migraine

Breast cancer is small + disappears 10 years after stop

Cervical cancer risk doubles with 10 years use

18
Q

Pregnancy Pharmacokinetics problems

Administration

A

Oral route - “morning sickness” nausea/vomiting
- Increase gastric emptying and gut motility

Intramuscular route - Blood flow may increase, so absorption may also increase using this route

Inhalation - Increased cardiac output and decreased tidal volume may increase absorption of inhaled drugs

19
Q

Metabolism

A

Oestrogen and progestogens can induce or inhibit liver P450 enzymes, increasing or reducing metabolism.

Phenytoin levels reduced
Theophylline levels increased

20
Q

Excretion

A

GFR is increased in pregnancy by 50%

reduces plasma concentration and increases drug clearance

21
Q

Distribution

A

Increase plasma volume + fat will change distribution

Greater dilution of plasma will decrease plasma proteins

22
Q

Placenta

A

Attach the fetus to the uterine wall
Provide nutrients to the fetus
Allow the fetus to transfer waste products to the mother’s blood (carbon dioxide and urea)

Mother to Fetus
Oxygen, Glucose, Amino acids, Vitamins, Ions
Lipids, fatty acids & glycerol, Abs, Viruses, Alcohol

23
Q

Placental Transfer

Depends on:

A

Molecular weight (smaller sizes will cross more easily)
Polarity (non-polar cross more readily)
Lipid solubility (lipid soluble drugs will cross)
Placenta may also metabolise some drugs

Lipophilic, Non-Ionised, <500Da MW cross placenta

24
Q

Methotrexate

Trimethoprim

A

Block the conversion of folate to THF by binding irreversibly to the enzyme

25
Q

Retinoid drugs (eg isotretinoin) Problems

A
aortic arch anomalies 
ventricular septal defects
craniofacial malformations
oesophageal atresia 
pharyngeal gland abnormalities
Neural crest cell disruption
26
Q

NSAIDs Problems

A

causing orofacial clefts and cardiac septal defects

27
Q

ACE inhibitors/ARBs

Possible issues

A

Fetotoxicity- Toxic effect on the fetus later in pregnancy

renal dysfunction
Growth retardation
Structural malformations
Fetal death
Functional impairment
Carcinogenesis
28
Q

Category D

A

Evidence of human fetal risk exists,

benefits may outweigh risks in certain situations
(eg, life-threatening disorders, serious disorders for which saferdrugscannot be used or are ineffective).

29
Q

Category X

A

Proven fetal risks outweigh any possible benefit.