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Repro/endo Pharm > Repro 1 > Flashcards

Repro 1 Flashcards

1
Q

Name the drugs for induction of labor/control of post pardum bleeding

A
  1. Misoprostol
  2. Dinoprostone
  3. Carboprost
  4. Oxytocin
  5. Ergot alkaloids
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2
Q

Name the drugs for patent ductus arteriosos

A

Maintain - alprostadil
Close - indomethacin, Ibuprofen

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3
Q

Name corticosteroids used

A
  1. Cortisol
  2. Betamethasone
  3. Dexamethasone
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4
Q

Drugs for newborns (given right after birth)

A
  1. Erythromycin ointment
  2. Vitamin K
  3. Hepatitis B vaccine
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5
Q

Delaying labor drugs

A
  1. Indomethacin
  2. Nifedipine
  3. Terbutaline
  4. MgSO4
  5. Atosiban
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6
Q

Antihypertensives for pregnancy

A
  1. A-methyldopa (a2 agonist)
  2. Labetalol (a/b blocker)
  3. Nifedipine (CCB)
  4. Hydralazine (for severe, given IV)
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7
Q

What are the teratogen risk categories

A

A- low chance of fetal harm
D- evidence of fetal harm but benifits may outweigh negatives in some instances
X- contraindicated in pregnancy or in women who may become pregnant

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8
Q

What stops prostaglandins from acting on maternal tissue during pregnancy?

A

Enzyme PGDH inactivated amnion prositiglandins but it decreases during labor

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9
Q

What feedforward cascade is created in late gestation

A

Placental CRH stimulates fetal adrenal production of DHEA and cortisol

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10
Q

What is the role of connections and gap junctions in pregnancy

A

The allow for interconnectivity and extensive waves of depolarization over the large uterus

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11
Q

What changes do the cervix undergo doing ripening?

A

Collagen fibrils become disorganized and loosely packed

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12
Q

What drug is used for termination of pregnancy if less than 77 days and off label cervical ripening

A

Misoprostol. A prostaglandin E1 analog. This will also maintain the ductus arteriosus

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13
Q

What drug comes in a gel, vaginal insert, and suppository but it’s very expensive and needs refrigeration. What is an adverse effect

A

Dinoprostone. Mostly used for cervical ripening. Suppository will terminate pregnancy if before 20 weeks. Can cause fever unresponsive to NSAIDs

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14
Q

What drug can induced abortion but is mostly used for refractory bleeding after delivery

A

Carboprost. Prostaglandin F2a analog. Given by deep intramuscular injection

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15
Q

What drug causes prolonged tonic uterine contractions and constricts arterials and veins. What is its adverse effect

A

Ergot Alkaloids. Causes Saint Anthony’s fire, mania psychosis vomiting and gangrene of digits

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16
Q

What management for preterm premature rupture of membranes happens at 34 weeks

A

Group B strep prophylaxis’ and single corticosteroids. If less than 34 weeks ad antimicrobials to prolong latency

17
Q

What management of pre-term rupture of membranes happens before 32 weeks

A

Magnesium sulfate for Nuro protection, antimicrobials, corticosteroid course, Group B strep prophylaxis and possibly tocolytics

18
Q

What do corticosteroids do in order to increase surfactant production

A

Induces transcription of proteins in alveolar type two pneumocytes

19
Q

Why is cortisol not administered to pregnant women

A

The placenta will metabolize Cortizone. Adding an OH at carbon 11 will allow the corticosteroid to pass

20
Q

What drug blocks synthesis of PGF2a in order to prevent contractions

A

Indomethacin. Agent of choice from 24 to 32 weeks. After 32 weeks can close ductus arteriosus

21
Q

What drug delays contractions by blocking calcium influx

A

Nifedipine. First choice from 32 to 34 weeks when NSAIDs are contraindicated

22
Q

What drug delays contractions by increasing CAMP and potassium channel mediated hyper polarization, dephosphorylation of myosin light chains

A

Terbutaline. Should not be used for more than 2 to 3 days in injectable form, should not be used orally to prevent labor

23
Q

What drug is used to prevent eclamptic seizures and has Neuro protection

A

Magnesium sulfate. Competes with calcium at channels

24
Q

What drug blocks oxytocin

A

Atosaban 

25
Q

What can cause tocolytic unresponsiveness

A

Sub clinical infection. Perform amniocentesis to measure glucose and look for subclinical infections prior to administering tocolytics

26
Q

What drug is given to babies to prevent bleeding

A

Vitamin K

27
Q

What parentally administer drug maintains a patent ductus arteriosus

A

Alprostadil. Can cause pyrexia

28
Q

What is a risk factor for using ibuprofen to close a patent ductus arteriosus

A

Decreases kidney function

29
Q

What should be avoided in hypertension during pregnancy

A

Thiazides because the impact volume contraction and ace inhibitors/Arbes/spironolactone (androgen)

Repro/endo Pharm (4 decks)

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