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Repro/endo Pharm > Gyn Pharm > Flashcards

Gyn Pharm Flashcards

1
Q

3 antibiotics for Gardinella Vaginallis

A

Metronidazol, Tinidazole- DNA sythesis inhibitor
clindamycin- 50s subunit inhibitor

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2
Q

MOA of -nidazole

A

Reduction of nitro group = strand breaks and loss of DNA structure

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3
Q

Side effects of nitroimidazole

A

Disulfide like reactions

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4
Q

Lincosamides treat 2 extra diseases

A

PID and TSS.
Can cause pseudomembranous colitis
Actively transported to abscesses

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5
Q

Tx for candidias and MOA

A

-fluconazole
Inhibit conversion of lanosterol by cyp450 disrupting the membrane

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6
Q

Side effects of Fluconazole

A

Torsades, contraindicated in renal disease and pregnancy

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7
Q

Thx for Trichamonas

A

Metronidazole or tinidazole

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8
Q

How to treat cervicitis (gonorrhea and chlamydia)

A

Ceftriaxone - IM
Azithromycin - PO

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9
Q

When gen is Ceftriaxone and what is important about it’s mode of delivery

A

3rd gen. Penetrates the CSF (from IM)

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10
Q

MOa of Azithromycin

A

50s subunit inhibitor

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11
Q

Why is doxycycline not recommended in pregnancy

A

It is a strong chelator of iron

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12
Q

Drugs for PID

A

Outpatient
Ceftriaxone and doxycycline (maybe add metronidazole
Inpatient
Doxycycline PLUS cefoxitin or cefotetan.

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13
Q

MOA of gentamycin

A

(Amino glycoside) inhibits 30s subunit

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14
Q

What bacteria are resistant to gentamycin and why

A

Anaerobic because it requires oxygen transport to be effective

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15
Q

What toxicity does gentamycin have

A

Neuro and Nephro. Risk greater in renal disease, prolonged therapy. ototoxicity is reversible

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16
Q

What is treatment for herpies II. What do the MOA

A

-cyclocir
MOA- vírus kinases activate it and it inhibits viral polymerase.
Resistance is by virus that don’t produce thymadine kinase

17
Q

What is the TX for Syphilis

A

Benzathine penacillin, doxycycline
Neuro syphilis gets aqueous or procain penicillin

18
Q

Thx for granuloma Iguinale

A

Azithromycin (50s subunit inhibitor)

19
Q

What’s treats TSS

A

Vancomycin. But bacteria are becoming resistant due to d-ala d- Lac or Ser isotopes

20
Q

TD for group B strep

A

Penicillin G or ampocillin

21
Q

Thx for post pardum endometritis

A

Gentamycin plus clindamycin
Or
Ampicillin sulbactam

Repro/endo Pharm (4 decks)

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