Gyn Pharm

Question 1

3 antibiotics for Gardinella Vaginallis

Answer 1

Metronidazol, Tinidazole- DNA sythesis inhibitor
clindamycin- 50s subunit inhibitor

Question 2

MOA of -nidazole

Answer 2

Reduction of nitro group = strand breaks and loss of DNA structure

Question 3

Side effects of nitroimidazole

Answer 3

Disulfide like reactions

Question 4

Lincosamides treat 2 extra diseases

Answer 4

PID and TSS.
Can cause pseudomembranous colitis
Actively transported to abscesses

Question 5

Tx for candidias and MOA

Answer 5

-fluconazole
Inhibit conversion of lanosterol by cyp450 disrupting the membrane

Question 6

Side effects of Fluconazole

Answer 6

Torsades, contraindicated in renal disease and pregnancy

Question 7

Thx for Trichamonas

Answer 7

Metronidazole or tinidazole

Question 8

How to treat cervicitis (gonorrhea and chlamydia)

Answer 8

Ceftriaxone - IM
Azithromycin - PO

Question 9

When gen is Ceftriaxone and what is important about it’s mode of delivery

Answer 9

3rd gen. Penetrates the CSF (from IM)

Question 10

MOa of Azithromycin

Answer 10

50s subunit inhibitor

Question 11

Why is doxycycline not recommended in pregnancy

Answer 11

It is a strong chelator of iron

Question 12

Drugs for PID

Answer 12

Outpatient
Ceftriaxone and doxycycline (maybe add metronidazole
Inpatient
Doxycycline PLUS cefoxitin or cefotetan.

Question 13

MOA of gentamycin

Answer 13

(Amino glycoside) inhibits 30s subunit

Question 14

What bacteria are resistant to gentamycin and why

Answer 14

Anaerobic because it requires oxygen transport to be effective

Question 15

What toxicity does gentamycin have

Answer 15

Neuro and Nephro. Risk greater in renal disease, prolonged therapy. ototoxicity is reversible

Question 16

What is treatment for herpies II. What do the MOA

Answer 16

-cyclocir
MOA- vírus kinases activate it and it inhibits viral polymerase.
Resistance is by virus that don’t produce thymadine kinase

Question 17

What is the TX for Syphilis

Answer 17

Benzathine penacillin, doxycycline
Neuro syphilis gets aqueous or procain penicillin

Question 18

Thx for granuloma Iguinale

Answer 18

Azithromycin (50s subunit inhibitor)

Question 19

What’s treats TSS

Answer 19

Vancomycin. But bacteria are becoming resistant due to d-ala d- Lac or Ser isotopes

Question 20

TD for group B strep

Answer 20

Penicillin G or ampocillin

Question 21

Thx for post pardum endometritis

Answer 21

Gentamycin plus clindamycin
Or
Ampicillin sulbactam