Menopause Drugs Flashcards
If patient has a uterus, what kind of post menopausal drug do they need
Estrogen AND progesterone
Estrogen will cause endometrial hyperplasia and cancer
What is menopause
12 full months without menses
Avaliable estrogen compounds
ESTR drugs.
Estradiol, CE, EE, Estropipate
What are the progestinic compounds
Medroxyprogesterone (MPA)
Methylyestosterone
Progesterone
What are estrogen effects
Decreased production of
1. Cholesterol (LDL)
2. Antithrombin
3. Osteoclast is activity
Increased production of
1. Triglycerides (HDL)
2. Clotting factors
3. Platelet aggregation
4. Fluid and salt retention
5. Thyroid binding globulin
What are harms from estrogen therapy
Dementia, gallbladder disease, stroke, thrombus, urinary incontinence
What are the benifits to estrogen therapy
Lower breast cancer, fractures and diabetes
What are harms to progesterone and estrogen therapy
Breast cancer, CHD, dementia, gallbladder disease, stroke, venous thrombosis, UI
What are benifits to dual therapy
Less colorectal therapy, diabetes and fractures.
What is the true purpose of estrogen therapy
For vaso motor symptoms and vaginal changes. (Hot flashes, trouble sleeping)
Can premenopausal women be treated with this
Yes, in moderate to severe symptoms.
How long should women stay on hormone replacement
Lowest dose for shortest period of time. NOT LIFELONG
When does stroke and breast cancer chance increase
After 3-5 years. Risks decrease/cease after stopping therapy
Selective estrogen receptor modulators goal and names
To be agonists in good areas and and antagonists in bad areas (breast)
1. Osprmifine
2. Clomiphene
Look for -ifine
What is a bazedoxifene
It is a TSEC. Only sold in pill with estrogen
