Repair Flashcards
Describe the timeline for inflammation in the skin. Day one.
Clot and neutrophils.
Describe the timeline for inflammation in the skin. Day 2
Epithelial cells migrate under clot.
Describe the timeline for inflammation in the skin. Day 3
Macs replace neutrophils.
Describe the timeline for inflammation in the skin. Day 4
Fibroblast follow macs
Describe the timeline for inflammation in the skin. Day 5.
Angiogenesis.
Fibroblasts and angiogenesis are collectively called
Granulation tissue
Describe the timeline for inflammation in the skin. Day 7-14
Increased collagen and lower fibrin clot.
When is the collagen the highest?
1 month.
When’s the strength reach its peak?
4 months
What causes contracture?
Myofibroblasts.
Keloids are causes by
Increase fibroblast activity. There’s no remodeling.
Timp are over active and inactivate the regulator for collagen (mmt which is a zn cofactor)
Describe the timeline for inflammation in the heart.
1: monocytes.
2: macs
3: angiogenesis
4: fibroblasts
5: collagen.
What growth factor is only involved with fibroblasts?
EGF (endothelial)
When is the PDGF released?
When platelets hit the ECM.
What’s PDGF do?
Increases fibroblasts
Collagen
Monocytes
What does TGFb do?
Most important fibroblast gf.
Increase collagen and monocytes
VEGF is involved with what?
Angiogenesis
Comes with granulation tissue
FGF Is what?
Released by fibroblasts and increases fibroblasts, monocytes, and angio.
No Collagen.
Which GF involve collagen?
PDGF
TGFb
Mac 1 released what? Whats a Mac 1 do?
Il 1 and 2 and 23
Proinflamm
What’s a Mac 2 do?
Repair.
Also releases TGFb
Anastomoses is?
Tubuluar connection between two tubes
Adhesion?
Abnormal connection of fibrin followed by collagen
Fistula
Abnormal connection with a lumen
Hernia
Abnormal Protrusion
What is a Labile cell? Characteristics? Where are some?
Labile is always replicating. Mucosa and epithelium. Epiderm
What’s a stable cell? Characteristics? And where?
Able to replicate if damaged but not continually. Mesoderm. Typically undergo hyperplasia. Liver.
Permanent type cell? Example?
Brain and heart and not able to undergo regeneration.
