Renin-Angiotensin System

Question 1

What are the factors that increase Renin release???

Answer 1

A decrease in arterial BP
A decrease in BP in glomerular vessels
A increase in the loss of sodium, water
A increase in sympathetic activity.

Question 2

What are the factors that decrease Renin release???

Answer 2

Na water retention
An increase in BP
Activation of AT1 receptors

Question 3

What converts angiotensinogen to angiotensin I???

Answer 3

Renin

Question 4

What converts angiotensin I to angiotensin II???

Answer 4

Angiotensin Converting Enzyme (ACE)

Question 5

Where are renin and prorenin stored???

Answer 5

JG cells

Question 6

What converts prorenin to renin???

Answer 6

proconvertase I or cathepsin B

Question 7

What controls Renin secretion???

Answer 7

Macula densa pathway
Intrarenal baroreceptor pathway
Beta-receptor pathway

Question 8

What is the macula densa pathway???

Answer 8

Made up of epithelial cells in thick ascending limb of the nephron.

Question 9

What are the physiological factors modifying renin release???

Answer 9

Systemic blood pressure
Dietary salt intake
Pharmacological agents

Question 10

What is ACE???

Answer 10

A glycoprotein
A nonspecific enzyme that catalyses diverse amino
acids