Chemistry of agents which affect lung function

Question 1

What are the qualities behind both Alpha and Beta adrenoreceptors???

Answer 1

. Noradrenaline has a greater potency for alpha adrenoceptors than for beta-adrenoreceptors.

. Phenol Groups are important for beta receptors in particular.

. Addition of a methyl group in alpha position increases alpha 2activity.

Question 2

What are some attributes do meta substituents must have in the development of Salbutamol???

Answer 2

They have to be able to take part in Hydrogen bonding.

Bulky meta substituents prevent the adoption of conformation.

EW G has a negative effect on activity.

The CH2OH group can be extended to CH2CH2OH but no further.