Renal_Medicine & Surgery Flashcards

1
Q

AKI - key things to do?

A

1) Check trend (compared to baseline creatinine)
2) Check drug chart (any nephrotoxic?) –> remove/replace

  • CANDA: Contrast (keep very hydrated), Aminoglycosides (Gent), NSAIDs, Diuretics, ACEi
  • NOTE: DO NOT GIVE Metformin if kidney issue/low GFR - increases risk of lactic acidosis but unlikely to cause AKI

3) Check fluids (pre-renal - dehydration) –> give fluids

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2
Q

What is the AKI checklist?

A

Check baseline creatinine

Check fluid status

Check drug chart

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3
Q

Different measures of kidney function?

A

Measures of kidney function:

  • Serum creatinine concentration
    • Creatinine = breakdown product of protein metabolism (small amount produced constantly)
    • Freely filtered through kindey (concentration in blood: urine is the same) for excretion
    • Produced & excreted @constant rate SO reduced renal function –> reduced creatinine excretion –> raised serum creatinine concentration
  • eGFR (serum creatinine, age, sex, ethnicity) - reflection of glomerular filtration rate
  • Creatinine clearance (CrCl) - eGFR factors + height/weight
    • NOTE: Cockroft & Gault equation
  • Urea
    • Nitrogenous waste product of protein metabolism (like creatinine) but some active reabsorption in kidneys (e.g. in dehydration)
    • Causes of increase: DEHYDRATION, upper GI bleed, high protein diet
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4
Q

AKI - def? Severity stages? Breakdown by pathology? Key things to do? Ix? Mx?

A

Def: abrupt loss of kidney function resulting in dysregulation of fluid balance + electrolytes & retention of nitrogenous waste products

Severity defined based on creatinine/urine output:

  • Stage 1: 1.5-1.9x baseline/UO <0.5mL/kg/hr for 6-12hrs
  • Stage 2: 2-2.9x baseline/UO <0.5mL/kg/hr for >12hrs
  • Stage 3: >3x baseline/UO <0.3mL/kg/hr for >24hrs OR anuria >12hrs

Breakdown by pathology:

  • Pre-renal - HYPOPERFUSION
    • Hypovolemia (e.g. dehydration/upper GI bleed -> less circulating volume)
    • Sepsis/Anaphylaxis (widespread vasodilation -> reduced perfusion pressure)
    • HF (heart pumping less effectively -> less blood reaches kidneys)
    • RAS (mechanical obstruction of blood flow to kidneys)
  • Renal - KIDNEY-SPECIFIC –> renal referral
    • Acute tubular necrosis (following pre-renal AKI, high CK)
    • Glomerulus = Glomerulonephritis
    • Interstitium = acute interstitial nephritis (low-grade fever, elevated urinary eosinophils, commonly from NSAIDs)
    • Blood vessels = vasculitis
    • Toxin accumulation = nephrotoxic drugs (ACEi, thiazide diuretic), rhabdomyolysis (myoglobin)
  • Post-renal - OBSTRUCTION –> urology referral
    • Ureteric calculus
    • BPH
    • Cancer (prostrate, bladder)

Key things to do:

  • Check trend (compared to baseline creatinine)
  • Check drug chart (any nephrotoxic?) –> remove/replace
    • CANDA: Contrast (keep very hydrated), Aminoglycosides (Gent), NSAIDs, Diuretics, ACEi
    • NOTE: DO NOT GIVE Metformin if kidney issue/low GFR - increases risk of lactic acidosis but unlikely to cause AKI
  • 3) Check fluids (pre-renal - dehydration) –> give fluids

Ix:

  • Bedside - urinalysis (haematuria, inf, BM, PCR)
    • Red cell casts - glomerulonephritis
    • White cell casts = pyelonephritis
  • Bloods - U&E, AI screen (ANCA), CK
  • Imaging - renal USS (stones, vascular thrombosis)

Mx:

  • Identify & Mx the cause
  • Hypovolaemic - IV fluid bolus
  • Hypervolaemic - if pul oedema –> loop diuretic (furosemide) + Na restriciton
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5
Q

Haemodialysis - access? How does it work? How often? Indications? Complications?

A

Access - 2 points (one for blood to come out of and one to go back into):

  • AV fistula (surgical anastomoses between artery & vein) OR Tesio (tunnelled central line)

How does dialysis machine work:

  • Box with dialysate fluid in it
  • Blood in separate tube going through box
  • Semi-permeable membrane between dialysis fluid & blood - diffusion between the two - K+, Na+, Ca2+, Mg2+, Cl-, Glucose, Bicarbonate
    • End-stage renal failure will not be able to excrete potassium –> hyperkalemia - blood high in K+, dialysate low in K+ –> diffusion across concentration gradient
    • End-stage renal failure will not be able to retain bicarbonate in kidneys = at risk of metabolic acidosis - blood low in bicarbonate, dialysate high in bicarbonate –> diffusion across concentration gradient
    • End-stage renal failure = low UO –> fluid retention –> -ve pressure created in dialysate compartment –> H2O drawn into dialysate from blood = ULTRAFILTRATION

How often - 4 times per week

Dialysis indications: HUMP

  • Hyperkalaemia (refractory)
  • Uraemic complications
  • Metabolic acidosis (context of poor renal funct)
  • Pul oedema (refractory & hypoxic)

Complications: infection, CVD, fluid balance irregularities

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6
Q

CKD - Key kidney functions? How do these relate to kidney failure? Ix? Classification? Mx? Types of renal replacement therapy?

A

Kidney key functions –> failure:

  • Fluid balance –catheter–> fluid overload
  • Electrolyte homeostasis –> hyperkalemia, acidosis
  • Waste excretion –> uraemia
  • Hormone production (EPO, Vit D activation with 1alpha-hydroxylase, renin –> angiontensin –> aldosterone axis) –> anaemia, hypocalcemia, hyperkalaemia/hyponatremia/low BP

​CKD Ix:

  • FBC, U&E (GFR, potassium), blood glucose (diabetic nephropathy), abs (e.g. anti-DNA for SLE)
  • US, renal biopsy

Classification by eGFR:

  • 1 ≥90, 2 ≥60, 3a ≥45, 3b ≥30, 4 ≥15, 5 <15
  • NOTE: 5 needs renal replacement therapy

CKD Mx:

  • Modify RFs - anti-HTN, good glycaemic control (DM)
  • Fluid balance - fluid & salt restriction
  • Anemia - EPO-stimulating agents
  • Hypocalcemia (& hyperphosphatemic) - vit D supplements, phosphate binders
  • Renal replacement therapy - for stage 5 disease (end-stage renal failure) - GFR <15
    • Haemodialysis
      • Blood passed through dialyzer - removes waste & balances electrolytes
      • Vascular access via tunneled central line or AV fistula
      • 4 times/wk
      • Complications: inf, CVD, fluid balance irregularities
    • Peritoneal dialysis
      • Peritoneum is used as membrane and dialysate instilled into peritoneum
      • Can be done @home BUT increased risk of infection
    • Renal transplant - lasts 10-20yrs
      • Complications: rejection, recurrence of disease, immunosupression
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7
Q

Nephrotic vs nephritic syndrome

  • Glomerular structure and podocyte function?
  • Nephritic - def? key signs? causes?
  • Nephrotic - def? key signs? causes?
A

Kidney glomerular structure:

  • Capillary > Endothelial cells > Glomerular basement membrane (GBM) > Foot processes of podocyte
  • Podocyte function: prevent protein leaking into the filtrate

Nephritic = proliferative - inflammation of glomerulus & nephrons –> capillary becomes leaky –> blood & protein leak

  • Key: blood, protein, increased creatinine, possible trigger (e.g. inf), acute/subacute disease progression
  • Causes: often immune-mediated
    • Post-streptococcal glomerulonephritis - molecular mimicry - antigen in kidneys accidentally recognised as strep antigen after inf
      • Nephritic - more HTN
      • Weeks after GAS inf (pharyngitis, skin)
      • Ix: ASO titre (high/low C3)
      • Mx: conservative - BP control
      • No long-term problems
    • IgA nephropathy (Berger’s disease) - generate abn IgA –> abs attach & form immune complexes = sticks & get stuck in glomerular capillaries –> activate compliment –> inflammation
      • Nephritic - more proteinuria
      • Sx: abdo pain, rash, arthritis
      • Days post-resp/GI inf
      • Mx: BP control, steroid
      • 40% get renal failure
      • Assoc w/ IgA conditions (HSP, Coeliac disease)
    • Henoch-Schonlein Purpura (HSP) - related to IgA nephropathy but is WIDESPREAD (IgA limited to kidneys)
      • Purpuric rash​ (buttocks/extensors), arthritis, abdo pain, Hx URTI
      • Mx: spontaneous resolution ± steroids
    • Haemolytic Uraemic Syndrome (HUS) - MAHA, thrombocytopenia, E.Coli (O157)
    • Goodpasture’s syndrome (anti-GBM disease) - pul haemorrhage, rapidly progressing glomerulonephritis + anti-GBM abs
    • Granulomatosis with polyangiitis (Wegner’s) - chronic sinusitis + lung haemorrhage, PR3 (cANCA)
    • SLE

Nephrotic = non-proliferative - (urinary protein loss >3.5g/day) from Podocyte effacement

  • NOTE: 24-hr urine collection not commonly done so better marker is spot urine protein: creatinine ratio >300mg/mmol
  • Key: high protein, hypoalbuminaemia, oedema (face), thrombosis (main coag factor loss in urine is anti-thrombin 3 = one of the bodies main anticoagulant mechanisms –> hypercoagulable state) –> VTE
  • Renal biopsy to determine type –> causes:
    • Minimal change disease - children –> Tx: steroids
    • Focal segmental glomerulosclerosis - most common in adults, assoc w/ obesity, DM & HIV
    • Membranous glomerulonephritis - 2nd most common in adults, idiopathic
    • Amyloidosis –> Ix: CONGO RED STAIN
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8
Q

Benign prostatic hyperplasia (BPH) - def? Sx? Ix? Mx?

A

Def: slowly progressive hyperplasia of periurethral (transition) zone of prostate gland –> urinary outflow obstruction

  • Common - occuring primarily in elderly men

Sx: lower urinary tract symptoms (FUND HIPS)

Ix: urinalysis (UTI), PSA (cancer) ± US/CT (abdo/pelvis)/cystoscopy

Mx:

  • Acute retention = CATHETERISE
  • Conservative - watchful waiting
  • Medical:
    • Alpha-blocker (relax sm muscle around prostatic urethra) e.g. tamsulosin
    • 5-alpha-reductase inhibitor (reduce conversion of testosterone –> dihydrotestosterone - reducing androgenic stimulation of prostate) e.g. finasteride
  • Surgical: TURP (transurethral resection of the prostate - shave extra prostate), open prostatectomy
    • NOTE: TURP not curative - will continue to grow
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9
Q

Mneumonic for urinary Sx?

A

LUTS - FUND HHIPS

  • Storage Sx (difficulty keeping urine in bladder):
    • Frequency
    • Urgency
    • Nocturia
    • Dysuria
  • Voiding Sx (difficulty emptying urine from bladder):
    • Hesitancy (long time to start) & Haematuria
    • Incomplete emptying
    • Poor stream
    • Straining (effort to start)
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10
Q

Urinary tract calculi - def? presentation? Stone types? Ix? Mx? When to ADMIT/what to do if managed @home?

A

Def: crystal deposition within the urinary tract

Presentation: severe loin to groin pain (ureteric colic - starts around back and moves towards groin)

Stone types:

  • Ca oxalate (80%)
  • Mg Ammonium Phosphate (struvite) - likely staghorn calculi
    • Associated with proteus mirabilis inf
  • Urate
  • Cysteine

Ix:

  • Bedside - urine dip (microscopic haematuria)
  • Bloods - U&E (post-renal AKI)
  • Imaging - gold standard non-contrast CT KUB (kidneys, ureters, bladder)
    • Contrast is excreted by kidneys - looking for bright white light of Ca –> if you give contrast it will mask the finding

Mx:

  • Infected & obstructed = pyonephrosis –> URGENT decompression via NEPHROSTOMY (or retrograde w/ JJ stent)
    • Opening between kidney & skin w/ nephrostomy bag for external collection
    • Nephro (kidney) stomy (opening)
  • <5mm (on CT) - allow spontaneous passing, retain stone for analysis
  • >5mm (on CT):
    • Ureteroscopic lithotripsy - endoscope into ureter & using mechanical force/laser to destroy stone
      • Uretero (through ureter) scopic (camera) Litho (stone) tripsy (crush)
    • Extracorporeal shockwave lithotripsy - external USS to destroy stone
      • Extra (outside) corporeal (body) shockwave (USS) Lithtripsy (crushing stone)
    • Percutaneous nephrolithotomy - ONLY if stone in kidney (e.g. staghorn calculi), extract stone through skin in back
      • Percutaneous (through skin) Nephro (kidney) lith (stone) otomy (cutting)

When to ADMIT:

  • Pain not controlled
  • Significantly impaired renal function
  • Single kidney
  • Pyrexia/sepsis
  • Stone >5mm

If managed at home:

  • High fluid intake + return if pain worsening/develop temperature
  • OPA in 4 weeks with CT-KUB on arrival –> if stone still present need lithotripsy/nephrolithotomy
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11
Q

Scrotal masses - ddx?

A

DDx:

  • Testicular torsion - EMERGENCY & TIME-URGENT
    • Elevated testis, loss of cremasteric reflex, very tender
    • Tx: bilateral orchidopexy (orchidectomy - if necrotic)
  • Can you feel above swelling?
    • YES - swelling separate from testis?
      • YES - Epididymal cyst OR Varicocele
      • NO - Tender?
        • YES - Epididymo-orchitis
        • NO - Hydrocele OR Tumour
    • NO - Inguinal hernia
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12
Q

Hydrocele - def? Ix?

A

Def: collection of fluid in tunica vaginalis

Ix: US, testicular tumour markers (AFP & bHCG - secreted by tumour, LDH - necrosis), urine culture (inf)

Causes: idiopathic, inf, trauma, tumour

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13
Q

Varicocele - def? What side is more common? What is it associated with x2? How can I reduce swelling?

A

Def: distended veins of pampiniform plexus

Key points:

  • More common on left (the way left testicular vein drains into left renal vein)
  • Assoc w/ infertility, renal cancer
  • Swelling may reduce when lying down
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14
Q

Testicular cancer - Epidemiology & mets? Ix? Mx?

A

Epidemiology & mets:

  • Mets to para-aortic LNs
  • Most common malignancy in males 20-40yrs

Ix:

  • Blood testicular tumour markers: alpha-fetoprotein, beta-hCG, LDH (necrosis, others secreted by tumour itself)
  • Testicular US –> CT-CAP for staging (would likely do orchidectomy before CT)
  • Urine dip (look for infection) –> culture

Mx:

  • Orchidectomy – take inguinal approach (scrotal approach risks mets and inguinal is coming out the same way the testicle drops) - only time would not do this first is when respiratory compromise then would do chemo first
  • BEP chemotherapy follow-up = very good response typically
  • Very good prognosis - good/intermediate prognosis groups have >90% 5-yr survival
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15
Q

Hyperkalemia on ECG? Mx?

A

Worried about arrhythmia

ECG: tented T-waves, widened QRS complex

  • NOTE: hypokalemia - flattened (or inverted) T-waves & U waves

Mx:

  • Call for senior help = emergency
  • Ca Gluconate –> cardiac protection
  • 10 U Actrapid + 100ml 20% glucose –> insulin drives K into cells + prevent hypoglycaemia
  • Salbutamol –> drives K into cells
  • Bicarbonate –> reduce metabolic acidosis
  • Haemodialysis if refractory
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16
Q

Casts in urine on microscopy

A
  • RBC casts = glomerular disease –> PS glomerulonephritis, Buerger’s disease
  • WBC casts (neutrophils & eosinophils) –> acute interstitial nephritis, acute pyelonephritis
  • Fatty casts (lipids) - in polarised light have ‘Maltese Cross sign’ = nephrotic syndrome
  • Granular brown casts (degen epithelial cells from ischaemia) = pre-renal injury/nephrotoxic injury (e.g. meds) –> acute tubular necrosis
  • Waxy casts = chronic renal failure (often end-stage renal disease = <15 eGFR)
  • Hyaline casts (clear) = non-specific
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17
Q

Bladder cancer - presentation? Ix? Mx?

A

Most common = transitional cell carcinoma (urothelial)

Presentation:

  • Painless visible haematuria (or asymptomatic non-visible haematuria)
  • Irrigative LUTS (urgency, suprapubic pain)
  • Recurrent UTIs
  • Pain, weight loss, lymphoedema

Ix:

  • Initial:
    • Urine dip (blood, leucocytes)
    • MC&S (use MSU - RBCs & WBCs, no bacterial growth)
    • Bloods - FBC
  • Flexible cystoscopy (lower urinary tract) + CT-urogram (upper urinary track if visible haematuria –> if non-visible low-risk use US)
  • Dx & staging = Transurethral Bladder Tumour Resection (TURBT) - resects full tumour + histology
    • Intravesical therapy:
      • Bacillus Calmette-Guerin (BCG) instilled into bladder –> reduces superficial bladder cancer recurrence (causes immune response to remaining tumour cells, same substance as in BCG vaccine)
      • Mitomycin - cytotoxic chemo agent

Mx: 2wk wait urology

  • Muscle invasive = cystectomy (young people) or radiotherapy/chemotherapy (older)
  • Superficial = surveillance cystoscopies, intravesical chemo
  • Mets = systemic therapy
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18
Q

AD Polycystic Kidney Disease (PCK)

Presentation? Associations? Screening?

A

Presentation: HTN, abdo discomfort, blood in urine, FHx of IC haemorrhage

  • Cysts in kidneys prod renin –> HTN
  • Space occupying masses in abdo (renal/liver cysts)
  • Can bleed into cysts –> blood in urine

Associations:

  • Hepatic cysts
  • Berry aneurysms –> risk of ICH
  • Mitral valve prolapse

Family screening - renal USS

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19
Q

Urinary retention breakdown? Ix? Mx acute retention?

A
  • Acute - pain
  • Chronic – no pain
    • Low pressure
    • High pressure – renal impairment + hydronephrosis
      • LUTS with nocturnal enuresis

Acute Ix:

  • DRE - men & women (also PV exam)
  • Urine dip + MC&S
  • Bloods - FBC, U&E, PSA
  • Imaging - bladder scan (for acute), US KUB (for chronic)
  • Meds review:
    • stop anticholinergics
    • analgesia if needed
    • laxatives for constipation
20
Q

Acute urinary retention causes?

A

Men - usually enlarged prostate

Women - rare, detrusor instability

21
Q

What are anticholinergic effects?

A

Acute retention

ACute glaucoma

Tachycardia

Dry eyes/mouth

22
Q

What is post obstructive diuresis? Tx?

A

Prolonged urine production after catheter

Tx: IV fluids of half what urine production is

23
Q

What test would you do if there is left-sided varicocele?

A

kidney USS (can block of renal vein)

24
Q

Testicular torsion - presentation? Tx?

A

Presentation: sudden-onset pain, high fixed position, absent cremasteric reflex

Tx: bilateral orchidopexy (both sides as increased risk of torsion in the other side)

25
Q

Painless testicular lump, male >60yrs

A

Benign seminoma (spermatocytic)

26
Q

Young male, testicular lump, Beta-hCG

A

Non-seminoma

27
Q

Prolonged pain + swollen testicle, Hx >1 day - Dx? Tx?

A

Epididymo-orchitis (young = STI, old = E. coli)

  • Tx = ceftriaxone + doxy if secondary to STI
  • Gradual onset + pain relieved by testicular elevation
28
Q

Lower urinary tract Sx (LUTS) - def? Sx?

A

Def: a group of Sx involving the bladder, urinary sphincter, urethra and prostate gland

  • Storage - issues keeping urine in the bladder
    • Frequency
    • Urgency
    • Nocturia
    • Dysuria
  • Voiding - issues passing urine
    • Hesitancy
    • Incomplete emptying
    • Poor stream
    • Straining
29
Q

What is paraphimosis? Causes? Pathophysiology? Mx?

A

Paraphimosis def: unable to pull back the foreskin

Causes: tight foreskin (phimosis), a complication of urinary catheter (always remember to replace foreskin after withdrawing for catheter insertion)

Pathophysiology: constrictive effect of foreskin –> oedema of distal penis –> ischaemia/necrosis (if severe)

Mx: UROLOGICAL EMERGENCY - must be reduced ASAP

  • Reduce with - Lubricating jelly OR dextrose-soaked gauze
  • If difficult - needle used to make small holes in penis –> drainage of oedema
30
Q

Prostate cancer - Ix? Mx?

A

Ix:

  • PR exam, PSA
  • FBC, U&E, LFTs
  • Transrectal ultrasound (TRUS)-guided needle biopsy
    • Gleason score = PC grading
    • TNM staging
  • Multiparametric MRI

Mx: surgery/radiotherapy

  • Radial prostatectomy ± LN dissection
  • External beam radiotherapy/brachytherapy
  • Androgen-deprivation therapy (ADT)
31
Q

Crohn’s flair, AKI with very high urine protein: creatinine ratio, Dx? Key types?

A

Nephrotic syndrome caused by amyloidosis

Types:

  • AA – acute phase protein that increases in inflammatory conditions (e.g. IBD, RA)
  • AL – light chain, multiple myeloma –> clump in kidneys
32
Q

What do you need to do after inserting catheter for acute-on-chronic urinary retention?

A

Monitor catheter for urine output (may be a lag where kidneys struggle to reabsorb enough water)

33
Q

What is someone with CKD due to receive IV contrast at risk of? What should be given before hand?

A

Contrast nephropathy

IV 0.9% NaCl (1mL/kg) for volume expansion

34
Q

Elderly lady admitted after being found collapsed at home, how do I determine the most likely cause of her AKI?

A

1) Hypovolaemia if dehydration picture
2) Rhabdomyolysis if CK >10,000

35
Q

Nephrotic syndrome - test to determine type?

A

Renal biopsy

36
Q

Transmural inflame, “beads on a string” on renal angiography - Dx? Def? Presentation? Ix? Mx?

A

Polyarteritis nodosa - systemic vasculitis, only medium-sized vessels

  • NO anti-neutrophil cytoplasmic antibodies (ANCA) and does not involve small vessels unlike ANCA-associated vasculitis (GPA, EGPA, microscopic polyangiitis)

Presentation:

  • RFs: 40-60yrs, hep B inf (prevalence of hep B-PAN has reduced with hep B vaccination), hairy cell leukaemia
    • NOTE: hep C associated with purely cutaneous form of PAN –> high cryoglobulins
  • Skin - livedo reticularis, skin ulcers, bullous or vesicular eruptions, purpura, or skin infarction
  • Mononeuritis multiplex, paraesthesia (motor/sensory loss in peripheral nerve distribution)
  • Myalgia/arthralgia/muscle tenderness, abdo pain (ischaemia/infarct of bowel)
  • High diastolic BP (>90mmHg)
  • Systemic - fever, weight loss

Ix:

  • Bedside - MSU (rule out inf, RCC/severe proteinuria –> alternative Dx)
  • Bloods:
    • FBC (normocytic anaemia, raised Pl), U&E, LFTs (hep B/ischaemic hep)
    • CRP, ESR, CK, complement (esp in Hep-B-PAN), BC (endovascular inf can mimic)
    • HBV/HCV serology, cryoglobulins
    • Ab screen - ANCA, ANA (CTD)/DS-DNA, RF/CCP, lupus-anticoag/IgG antiphospholipid/B2 glycoprotein (anti-phospholipid syndrome)
  • Imaging: angiography, echo (exclude endocarditis, atrial myxoma, or a left ventricular thrombus)
    • ± Biopsy of affected tissue = focal and segmental transmural necrotising inflammation in a medium-sized vessel

Mx:

  • Remission: cyclophosphamide + CSs
  • Maintenance: low-dose CSs + methotrexate
37
Q

Acute tubular necrosis - causes? def?

A

Def: renal tubular dysfunction/detachment from the basement membrane

  • Most common intrinsic renal cause of AKI
  • Causes:
    • Chronic ischaemia of renal tubules (shock/LVF) - initially pre-renal AKI
    • Nephrotoxic (lots of myo/haemoglobin, contrast, aminoglycosides e.g. gent, Ig light chains)
  • Can’t concentrate urine or regulate electrolytes –> high UO, high urine sodium
38
Q

Orthostatic hypotension, high protein on urine dip, constipation, bilateral carpal tunnel - what is the kidney biopsy likely to show?

A

Autonomic neuropathy (orthostatic hypotension, constipation)

Bilateral carpal tunnel DDx: protein infiltration (amyloidosis), pregnancy, hemochromatosis, acromegaly etc…

Dx: Amyloidosis - neuropathy, autonomic dysfunction, end-organ involvement

  • Apple green birefringence in polarised light with Congo Red stain
39
Q

low-grade fever, raised eosinophils in urine, red eyes, prev NSAID use, Dx?

A

TINU syndrome = red eyes (uveitis) AND acute interstitial nephritis

40
Q

Renal causes of raised eosinophils?

A

Acute interstitial nephritis - AKI, NSAIDs, raised urinary eosinophils

  • NOTE: TINU syndrome = red eyes + AIN

Churg-strauss syndrome aka eosinophilic granulomatosis with polyangiitis (EGPA)

  • Vasculitis (microscopic polyangitis), pANCA +ve (aka MPO)
  • Asthma + eosinophils + mononeuritis multiplex

Cholesterol embolism (rare) - livedo reticularis rash (same rash in anti-phospholipid syndrome)

41
Q

What can result in false urine +ve for blood?

A

Rhabdomyolysis - myoglobin

Ascorbic acid

Haemoglobinuria (haemolytic anaemia)

42
Q

Signs on blood that have CKD > AKI

A

Phosphate high (low Ca –> secondary hyperparathyroidism)

Hb low (low erythropoietin prod by the kidney)

43
Q

80yrs fallen at home + clinically dehydrated, very high CK, high serum creatinine, urine dip +ve for blood

What is going on? Tx? What finding is likely on biochem? Why is urine dip +ve for blood?

A

Rhabdomyolysis leaking myoglobin from muscle (due to injury/seizure/statins) –> acute tubular necrosis

Tx: fluids ± haemodialysis

Myoglobin has lots of phosphate and potassium (cells burst):

  • PO4 binds Ca = Hypocalcaemia
  • Hyperkalaemia

High myoglobin (cause false +ve reading)

44
Q

ATN vs pre-renal AKI?

A

If your tubules still work then they can control your electrolytes

In pre-renal: dehydration –> retention of Na to maintain oncotic pressure via aldosterone –> low urinary Na (<20)

In ATN: necrosis so above does not happen –> high urinary Na (>20)

  • ATN follows pre-renal AKI
45
Q

ANCA-assoc vasculitis breakdown? Presentation? Ix? Types based on Ix? Tx?

A

Presentation: ALL can cause renal impairment + rash (e.g. shins) ± low-grade pyrexia/fatigue

Ix - Rheumatological Ab screening:

  • ANA
  • ANCA
    • biopsies of BVs/affected organs e.g. kidneys

cANCA = PR3 (note: c=3):

  • Granulomatosis with polyangiitis (GPA) aka Wegener’s
    • Nasal bridge collapse/epistaxis, chronic sinusitis
      • DDx for nasal bridge collapse can be cocaine abuse​
    • Can develop pulmonary nodules/haemorrhage
    • Granulomas
    • Case: 52yrs, cough with blood, malaise, rashes, SoB, sinusitis for yrs
      • ABG - reduced PaO2, raised creatinine, cANCA +ve

pANCA = MPO (myeloperoxidase):

  • Eosinophilic granulomatosis with polyangiitis (EGPA) aka Churg-Strauss
    • Asthma + eosinophilia + mononeuritis multiplex (e.g. weakness in hand)
    • Granulomas
  • Microscopic polyangiitis - no granulomas

Tx:

  • Remission: cyclophosphamide + CSs
  • Maintenance: low-dose CSs + methotrexate
46
Q

Vasculitis breakdown

A

Large vessel - Aorta & major branches

  • GCA (temporal arteritis), Takayasu’s arteritis (occlusive vasculitis –> upper limb claudication, diminished/absent pulse)

Medium vessel - smaller arteries that supply blood to end organs

  • Polyarteritis nodosa (PAN), Kawasaki’s arteritis

Small vessel - arterioles & capillaries

  • ANCA-assoc: GPA, EGPA, microscopic polyangiitis
  • Immune-complex: anti-GBM, IgA vasculitis (HSP), cryoglobulinemic vasculitis, hypocomplementemic urticarial vasculitis

Thromboangitis obliterans (Buerger’s disease) - affects small & medium vessels in lower limb

  • Segmental occlusion, young male smokers, tortuous corkscrew collateral vessels on angiography
47
Q

Urinary incontinence - types & drug Tx?

A

Stress-incontinence (leak on laugh/cough): pseudoephedrine (2nd - Duloxetine)

Urge-incontinence (preceded by the urge to pass urine): anticholinergic e.g. Oxybutynin (not if >80yrs), Tolterodine

Overactive bladder syndrome (urge but not incontinence - increased freq + nocturia): same as urge incontinence