Renal Toxicology Flashcards
1
Q
What are the main components of the Nephron ?
A
- proximal tubule
- loop of Henle
- distal tubule
- collecting duct
- Bowman’s capsule
2
Q
Why is the Proximal convoluted tubule the most common site of toxicant-induced renal injury?
A
- leaky epithelium
- reabsorption of transport of organic anions, cations, low mw proteins
- P450 activity
- glomerular filtration toxicants concentrated in this area
3
Q
What does Aminoglycosides (gentamycin) do ?
A
causes acute proximal tubule necrosis in 10% of patients