Renal Toxicology Flashcards

1
Q

What are the main components of the Nephron ?

A
  1. proximal tubule
  2. loop of Henle
  3. distal tubule
  4. collecting duct
  5. Bowman’s capsule
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2
Q

Why is the Proximal convoluted tubule the most common site of toxicant-induced renal injury?

A
  • leaky epithelium
  • reabsorption of transport of organic anions, cations, low mw proteins
  • P450 activity
  • glomerular filtration toxicants concentrated in this area
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3
Q

What does Aminoglycosides (gentamycin) do ?

A

causes acute proximal tubule necrosis in 10% of patients

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