Renal Toxic Drugs Flashcards
name the five antibiotics that can cause interstitial nephritis
penicillins/cephalosporins ciporfloxacin vancomycin rifampin trimethoprim
other than antiobiotics what two drug classes can cause interstitial nephritis?
NSAIDs
and PPIs
what are two proton pump inhibitors that cause acute interstitial nephritis
omeprazole and lansoprazole
describe the three ways drugs cause interstitial nephritis
neo antigen
antigen mimicry
haptenization
what is haptenization?
when a drug binds a protein and that complex becomes immunogenic
what are three symptoms you can see with drug induces interstitial nephritis?
rash
fever
eosinophilia
name the three drugs that commonly cause acute tubular necrosis?
aminoglycoside
amphotericin b
iodinated radiocontrast dyes
what is the dye that causes ATN?
iohexol
which aminoglycoside has the least problems with ATN?
which has the most?
streptomycin
Neomycin and gentamicin
name the 6 drug classes that cause type 4 RTA?
NSAIDs ACE ARBs Tacrolimus Cyclosporine Trimethoprim
if someone has renal artery stenosis and you give an ACE for their HTN…what did you just do for them?
reduce their GFR even more because you caused more dilation of the efferent arteriole in the kidney
if you give NSAIDs…how does this affect GFR?
decreases because it constricts the afferent arteriole
if you give ACE/ARBs how does this affect the GFR?
decreases because efferent arteriole is dilated
NSAIDs cause which two renal toxicities?
AIN and RTA
PPIs cause which renal toxicity?
AIN
