Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Renal Week 3 > Nephritic and Nephrotic Syndromes > Flashcards

Nephritic and Nephrotic Syndromes Flashcards

1
Q

which of nephritic or nephrotic has hematuria?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

which of nephritic or nephrotic has RBC casts?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

which of nephritic or nephrotic has massive proteinuria?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

which of nephritic or nephrotic has hyperlipidemia?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

which of nephritic or nephrotic has hypoalbuminemia?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

which of nephritic or nephrotic has fatty casts or oval fat bodies in the urine?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

which of nephritic or nephrotic has lower proteinuria?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which of nephritic or nephrotic has elevated creatinine?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which of nephritic or nephrotic has hypertension?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

which of nephritic or nephrotic has hypogammaglobulinemia?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

which of nephritic or nephrotic has hypercoagulable state?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

why is there a hypercoagulable state in nephrotic syndrome?

A

lose antithrombin III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

which of nephritic or nephrotic has edema?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which of nephritic or nephrotic has tea colored urine?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

is post infectious GN nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

is proliferative lupus nephritic or nephrotic?

A

nephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

is membranoproliferative GN nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

is C3 glomerulopathy nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

is IgA nephropathy nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

is alport syndrome nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

is pauci immune GN nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

is anti glomerular basement membrane disease nephritic or nephrotic?

A

nephritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

is minimal change disease nephritic or nephrotic?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

is focal segmental glomerulosclerosis nephritic or nephrotic?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

is membranous nephropathy nephritic or nephrotic?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

is amyloidosis nephritic or nephrotic?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

is diabetic kidney disease nephritic or nephrotic?

A

nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

are C3/C4 up down or normal in post infectious GN?

A

C3 is down and C4 is sometimes down

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

what is a positive serology antibody in post infectious GN?

A

ASO antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

what two things deposit in post infectious GN and where do they deposit?

A

C3 and IgG…deposit in subepithelial space of the glomeruli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

what is the common organism that leads to post infectious GN? how long after infection does the glomerular nephropathy occur?

A

group A beta hemolytic strep…2-4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

name three commone presenting features with post infectious GN?

A

cola colored urine
periorbital edems
hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

what is the characteristic appearance of post infectious GN on IF?

A

starry sky or lumpy bumpy due to subepithelial immune complex bumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

what population is proliferative lupus nephritis most common in

A

blacks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

are C3/C4 levels up down or normal in proliferative lupus nephritis

A

both are down

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

name two common antibodies found in proliferative lupus nephritis

A

anti smith and ANA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

what is the mechanism of issue in diffuse proliferative lupus nephritis? where do these deposit?

A

immune complexes

subendothelial or intramembranous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

which nephritic syndrome often co presents as a nephrotic syndrome?

A

membranoproliferative GN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

what is type I membranoproliferative GN often associated with?

A

Hep B or Hep C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

what is the characteristic appearance of membranoproliferative GN on stains?

A

called tram track appearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

where does deposit happen in membranoproliferative GN? how does it appear on IF?

A

immune complex deposits on subendothelium…appears granular

42
Q

what goes wrong in C3 glomerulopathy?

A

mutation or antibodies that activate compliment molecules

43
Q

will C3 be low or high in C3 glomerulopathy?

A

will be low bc it is getting used up

44
Q

how does C3 glomerulopathy look on IF?

A

it appears light…but no antibodies…just C3 deposits

45
Q

are C3/C4 up down or normal in IgA nephropathy?

A

both are normal

46
Q

what does IgA nephropathy usually follow?

A

mucosal infection

47
Q

where do IgA complexes deposit in IgA nephropathy?

A

the mesangium

48
Q

describe how IgA nephropathy will look on light microscopy and IF?

A

light will have enlarged mesangium

IF will show IgA complex deposits in mesangium

49
Q

other than mucosal infections…name two things IgA nephropathy is associated with?

A

inflammatory bowel disease

ankylosing spondylitis

50
Q

are C3/C4 up down or normal in alport syndrome?

A

both are normal

51
Q

what is alport syndrome a problem with?

A

type IV collagen

52
Q

in alport syndrome…what does the issue with type IV collagen lead to?

A

thinning and splitting of the basement membrane

53
Q

what is the inheritance of alport syndrome?

A

x linked dominant

54
Q

what is the descriptive term for alport syndrome on EM?

A

basket weave appearance from the thinning and splitting of the basement membrane

55
Q

what are two other problems you can have with alport syndrome?

A

eye issues and deafness

56
Q

how do pauci immune GN appear on LM or EM?

A

crescent shaped glomeruli

57
Q

in pauci immune GN, what cells make up the crescent in the glomeruli?

A

macrophages and fibrin

58
Q

what are the two most common types of pauci immune GNs?

A

microscopic polyangitis

granulomatosis with polyangitis (wegeners)

59
Q

what is the antibody associated with pauci immune GNs?

A

ANCA

60
Q

is microscopic polyangitis P or C ANCA?

A

P ANCA

61
Q

is granulomatosis with polyangitis P or C ANCA?

A

C ANCA

62
Q

what is the result of IF testing in pauci immune GNs?

A

negative for anything because all mediated my neutrophils so do not appear on the IF

63
Q

does GPA or MPA have oropharynx involvement?

A

GPA

64
Q

which nephritic disease has a linear pattern on IF?

A

antiglomerular basement membrane disease

65
Q

what pattern will antiglomerular basement membrane disease cause in glomerulus?

A

crescent shape

66
Q

if antiglomerular basement membrane disease presents with pulmonary hemorrhage…you have what disease?

A

goodpastures

67
Q

how do we treat antiglomerular basement membrane disease?

A

immediate plasmapheresis

68
Q

what is the characteristic change seen in minimal change disease?

A

effacement of the foot processes on epithelium of Glomerulus

69
Q

what can we treat minimal change disease with?

A

corticosteroids

70
Q

what population commonly gets minimal change disease?

A

kids…most common nephrotic syndrome of kids

71
Q

name two common associations with minimal change disease

A

NSAIDs and lymphomas

72
Q

what two populations get focal segmental glomerulosclerosis a lot?

A

african americans and hispanics

73
Q

what are imaging findings in focal segmental glomerulosclerosis ?

A

segmental sclerosis and hyalinosis in the glomeruli

74
Q

what can happen to the epithelium focal segmental glomerulosclerosis?

A

effacement of foot processes

75
Q

name five common associations with focal segmental glomerulosclerosis

A 
HIV
Sickle cell disease
cyanotic heart disease
obesity 
heroin
76
Q

membranous nephropathy has what appearance on IF?

A

granular due to complexes

77
Q

what is the antibody that drives primary membranous nephropathy?

A

anti M type PLA2

78
Q

what is the characteristic description of membranous nephropathy on EM?

A

spike and dome

79
Q

name four common causes of secondary membranous nephropathy

A

NSAIDs
Hep B
Hep C
SLE

80
Q

in membranous nephropathy where do the immune complexes deposit?

A

subepithelial around the GBM

81
Q

the AL form of amyloidosis is associated with what?

A

plasma cell disorders

82
Q

the AA form of amyloidosis is associated with what?

A

chronic infections

83
Q

name the two staining buzz words for amyloidosis

A

apple green birefringence

congo red stain

84
Q

where does amyloid deposit in the kidney?

A

mesangium

85
Q

what are the two changes to the kidney seen histologically in diabetic kidney disease?

A

mesangial expansion

GBM thickening

86
Q

name the characteristic stain finding of diabetic nephropathy

A

kimmelstein wilson nodules

87
Q

what cell is in the kimmelstein wilson nodules? what disease are these common with?

A

eosinophils

diabetic nephropathy

88
Q

membranoproliferative GN is often associated with what two things?

A

hepatitis B and cryoglobulins

89
Q

what is the gene associated with FSGS?

A

APOL-1

90
Q

which nephrotic syndrome is a paraneoplastic syndrome?

A

membranous glomerulopathy

91
Q

which four nephritic and nephrotic syndromes present pulmonary and renal?

A

ANCA
Lupus
Cryoglobulins (membranoproliferative GN)
Goodpastures

92
Q

which four nephritic and nephrotic syndromes present with a rash?

A

ANCA
Lupus
Cryoglobulins
IgA vasculitis

93
Q

name the test that we use to determine the daily protein excretion

how do the numbers correlate?

A

spot urine protein creatinine ratio

1 = 1 g

94
Q

if we cannot do the protein creatinine ratio…what do we use?

A

24 hour urine collection

95
Q

what are three risks with nephrotic syndromes?

A

thrombosis
infections
accelerated atherosclerosis

96
Q

do children get hematuria from glomerular causes of urinary problems more often? what about adults?

A

glomerular for kids

urinary for adults

97
Q

what is the other name for the C-ANCA antibody?

A

PR3-ANCA

98
Q

what is the other name for the P-ANCA antibody?

A

MPO-ANCA

99
Q

PR3-ANCA stands for what?

A

anti-proteinase 3

100
Q

MPO-ANCA stands for what?

A

anti myeloperoxidase

Renal Week 3 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions