Renal Phys--> Distal convoluted Tubule

Question 1

What is considered the distal convoluted tubule?

Answer 1

Tubule after the Macula Densa

Question 2

What two important channels will you find here?

Answer 2

NCC- Na:Cl–> 1:1

TRPV5- Calcium

Question 3

Are there aqueporins in the convoluted tubule?

Answer 3

Nope

Question 4

How much sodium is reabsorbed here and how? With water?

Answer 4

5% via NCC

• no water follows
• making urine more dilute

Question 5

What is the percentage of Ca and Mg reabsorbed here?

Answer 5

Ca 7-10%

Mg 10%

Question 6

what is Giltleman syndrome? What drugs acts to imitate this disorder?

Answer 6

Defect in NCC channel

• Thiazides
• can be given to pt with recurrent Calcium kidney stones